Results 181 to 190 of about 9,563 (231)

Entdeckung eines antiviralen Elektronentransferprozesses zur Erzeugung katalytisch selbstversorgender viraler Restriktionsfaktoren

Angewandte Chemie, Volume 138, Issue 39, 21 September 2026.
CYB5R3 wird als mutmaßlicher Elektronentransferpartner von Viperin (RSAD2) identifiziert, was erklärt, warum die ER‐Lokalisation für die antivirale Aktivität erforderlich ist. Dieses Wissen ermöglichte die Entwicklung immunstiller, katalytisch selbstversorgender antiviraler Restriktionsfaktor‐Enzyme (iCAREs), die ein antivirales Nukleosidtriphosphat ...
Mengdi Wu, Nghi Thao Hoang, Deborah Grifagni, Meritxell Wu‐Lu, Yujie Sheng, Theo Situmorang, Pei‐Hsin Tai, Zheng Chen, Astrid Maluta, Mohammed Hakil, Bianca Susini, Hannah Florance, Peter‐Leon Hagedoorn, John Mark Sutton, Maria‐Andrea Mroginski, Simone Ciofi‐Baffoni, Kourosh H. Ebrahimi   +16 more
wiley   +1 more source

Freshwater-adapted polychaetes exhibit a complete enzymatic machinery for synthesizing long-chain polyunsaturated fatty acids. [PDF]

Open Biol
Bainour K, Zulkifli N, Sam KK, Navarro JC, Castro LFC, Glasby CJ, Shu-Chien AC, Monroig Ó.   +7 more
europepmc   +1 more source

Discovery of an Antiviral Electron Transfer Process to Create Catalytically Self‐Sufficient Viral Restriction Factors

Angewandte Chemie International Edition, Volume 65, Issue 39, 21 September 2026.
CYB5R3 is identified as a putative electron‐transfer partner of viperin (RSAD2), explaining why ER localisation is required for antiviral activity. Its utilisation enabled the engineering of immune‐silent, catalytically self‐sufficient antiviral restriction factor enzymes (iCAREs) that produce an antiviral nucleoside triphosphate analogue (ANTA ...
Mengdi Wu, Nghi Thao Hoang, Deborah Grifagni, Meritxell Wu‐Lu, Yujie Sheng, Theo Situmorang, Pei‐Hsin Tai, Zheng Chen, Astrid Maluta, Mohammed Hakil, Bianca Susini, Hannah Florance, Peter‐Leon Hagedoorn, John Mark Sutton, Maria‐Andrea Mroginski, Simone Ciofi‐Baffoni, Kourosh H. Ebrahimi   +16 more
wiley   +1 more source

Enhanced DHA Production in <i>Aurantiochytrium</i> by ω-3 Desaturase Integration and Fatty Acid Synthase Disruption. [PDF]

Mar Drugs
Wang Z, Wang Y, Wan W, Chen C, Wen W, Song X, Xuan J, Feng Y.   +7 more
europepmc   +1 more source

The Unsaturated/Saturated Fatty Acid Ratio: A Metabolic Hub and Therapeutic Vulnerability in Glioblastoma. [PDF]

Biomedicines
Dai X, Ku J, Li H, Yan R, Wang B.
europepmc   +1 more source

Iron overload disrupts lipid desaturation through SKN-1 signaling in <i>C. elegans</i>: implications for ferroptosis-based immunomodulatory biomaterials. [PDF]

Mater Today Bio
Dong Z, Liao Y, Shi H, Zhang J, Lin J, Liu Q, Zhang S, Fan X, Liu B, Wang Y, Zheng Y, Gao L.   +11 more
europepmc   +1 more source

Association of <i>FADS2</i> polymorphism rs174538 with fatty acid metabolism and disease severity in Japanese patients with Crohn's disease. [PDF]

World J Gastroenterol
Matsuzawa H, Ito Z, Uchiyama K, Motoi Y, Ohtaki Y, Iwashita Y, Suzuki S, Nakada T, Koido S, Kojima K, Murohashi K, Saruta M, Ohkusa T, Kubota T.   +13 more
europepmc   +1 more source

Comparative genomics across <i>Linum</i> illuminates the evolutionary basis of flax domestication, genome diversification, and seed oil biosynthesis. [PDF]

Front Genet
Yi L, Sa R, Mu Y, Zhang J, He R, Song Y, Zhou Y, Chen Y.   +7 more
europepmc   +1 more source

Is Sepsis an Essential Fatty Acids Deficiency State? [PDF]

Indian J Crit Care Med
Das UN.
europepmc   +1 more source

Genome analysis of the glycosphingolipid-producing green alga tetraselmis sp. NKG400013. [PDF]

DNA Res
Yasui R, Hosaka A, Ogata N, Ogawa T, Yohda M, Arakaki A, Kataoka K, Tanaka T.   +7 more
europepmc   +1 more source