Results 41 to 50 of about 18,623 (291)
Keratinocyte cadherin desmoglein 1 controls melanocyte behavior through paracrine signaling
Pigment Cell & Melanoma Research, 2020 The epidermis is the first line of defense against ultraviolet (UV) light from the sun. Keratinocytes and melanocytes respond to UV exposure by eliciting a tanning response dependent in part on paracrine signaling, but how keratinocyte:melanocyte ...
Christopher R. Arnette +9 more
semanticscholar +1 more source
Loss of flotillin expression results in weakened desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes [PDF]
, 2016 Desmosomes are adhesion plaques that mediate cell-cell adhesion in many tissues, including the epidermis, and generate mechanical resistance to tissues. The extracellular domains of desmosomal cadherin proteins, desmogleins and desmocollins, are required
Ali, Jawahir +7 more
core +1 more source
Frontiers in Immunology, 2022 Paraneoplastic pemphigus (PNP) is an autoimmune bullous disease associated with underlying neoplasms and characterized by antibodies against desmoglein 3 (Dsg 3) and plakins.
Xue Wang +28 more
doaj +1 more source
Differentiation-dependent glycosylation of cells in squamous cell epithelia detected by a mammalian lectin [PDF]
, 2002 The squamous stratified epithelia contain a proliferative (harboring mitotic activity) and a differentiating compartment. Due to the potential of protein-carbohyd rate interactions to regulate cellular activities we introduced a mammalian lectin to cyto-
Dvorankova, Barbora +7 more
core +1 more source
Journal of Medical Virology, 2020 Despite new therapies, the estimated 229 875 women living with ovarian cancer have a 5‐year survival rate of 47.6%. This cavity‐localized cancer lends itself to local administration of modalities, such as the oncolytic adenovirus (Ad) Ad5/3‐D24 ...
L. Kuryk, A. Møller
semanticscholar +1 more source
Do serum prolactin levels correlate with antibodies against desmoglein in pemphigus vulgaris?
Advanced Biomedical Research, 2016 Background: Pemphigus vulgaris is a chronic inflammatory disease of skin, the etiology of which is not completely known. Despite the latter, anti-desmoglein antibodies play a proven role in the pathogenesis.
Fariba Iraji +6 more
doaj +1 more source
, 2004 Dermatology continues to develop at a steady pace. In the past few years there have been exciting advances in our understanding of skin structure and function in health and disease and progress in genetics, epidemiology, immunology, pharmacology and ...
Boffa, Michael J.
core +1 more source
Desmoglein-2 as a prognostic and biomarker in ovarian cancer
Cancer Biology & Therapy, 2020 Greater than 80% of all cancer cases are carcinomas, formed by the malignant transformation of epithelial cells. One of the key features of epithelial tumors is the presence of intercellular junctions, which link cells to one another and act as barriers ...
Jiho Kim +8 more
semanticscholar +1 more source
Desmoglein-1, differentiation, and disease [PDF]
Journal of Clinical Investigation, 2013 Desmoglein-1 (DSG1), a desmosomal protein, maintains the structure of epidermis through its adhesive function. However, heterozygous mutations in DSG1 in humans result in abnormal differentiation, as does downregulation of DSG1 in human skin organ culture, suggesting that it may have important signaling functions. In this issue of the JCI, Harmon et al.
John R. Stanley, Christoph M. Hammers
openaire +3 more sources
Journal of Virology, 2020 Human adenovirus type 55 (HAdV55) has recently emerged as a highly virulent respiratory pathogen and has been linked to severe and even fatal pneumonia in immunocompetent adults.
Ying Feng +16 more
semanticscholar +1 more source