Frontiers in Immunology, 2019 Pemphigus is an autoimmune dermatosis in which mucocutaneous blisters are induced primarily by autoantibodies against Desmoglein (Dsg) 1 and 3. Pemphigus vulgaris (PV) usually is associated with autoantibodies against Dsg3 whereas pemphigus foliaceus (PF)
Elias Walter +6 more
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Desmosomal Junctions and Connexin-43 Remodeling in High-Pacing-Induced Heart Failure Dogs
Anatolian Journal of Cardiology, 2023 Background: While desmosomal junctions and gap junction remodeling are among the arrhythmogenic substrates, the fate of desmosomal and gap junctions in high-pacing-induced heart failure remains unclear. This aim of this study was to determine the fate of
Qing Wang +6 more
doaj +1 more source
A recalcitrant case of pemphigus treated with inebilizumab [PDF]
JAAD Case ReportsChristina M. Bear, BA +2 more
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The mapping of linear B-cell epitope regions in desmoglein 1 and 3 proteins : Recognition of immobilized peptides by pemphigus patients’ serum autoantibodies [PDF]
, 2013 Desmosomal transmembrane glycoproteins desmoglein 1and desmoglein 3 are targets of life-threatening autoimmune blistering disorders such as Pemphigus vulgaris (PV) and Pemphigus foliaceus(PF).
Bősze, Szilvia +5 more
core +1 more source
Sudden cardiac death in young athletes: Literature review of molecular basis [PDF]
, 2020 Intense athletic training and competition can rarely result in sudden cardiac death (SCD). Despite the introduction of pre-participation cardiovascular screening, especially among young competitive athletes, sport-related SCD remains a debated issue ...
Barbara Lombardo +5 more
core +1 more source
Identification of Desmogleins as Disease Targets [PDF]
Journal of Investigative Dermatology, 2007 While it had long been known that desmosomes were crucial for interconnecting cells in laboratory experiments, the link between desmosomal adhesion and human health was bolstered by several key experiments demonstrating that desmogleins were targeted in both autoimmune and infectious diseases.
Simpson, Cory L., Green, Kathleen J.
openaire +3 more sources
Limbal stem cell transplantation: clinical results, limits, and perspectives [PDF]
, 2018 Limbal stem cell deficiency (LSCD) is a clinical condition characterized by damage of cornea limbal stem cells, which results in an impairment of corneal epithelium turnover and in an invasion of the cornea by the conjunctival epithelium.
Bruscolini, Alice +3 more
core +1 more source
Cortical tension regulates desmosomal morphogenesis
Frontiers in Cell and Developmental Biology, 2022 Mechanical stability is a fundamental and essential property of epithelial cell sheets. It is in large part determined by cell-cell adhesion sites that are tightly integrated by the cortical cytoskeleton.
Marcin Moch +2 more
doaj +1 more source
Characterization of Desmoglein-3 Epitope Region Peptides as Synthetic Antigens: Analysis of their in vitro T-cell Stimulating Efficacy, Cytotoxicity, Stability and their Conformational Features [PDF]
, 2015 Desmoglein-3 (Dsg3) adhesion protein is the main target of autoantibodies and autoreactive T cells in Pemphigus vulgaris (PV) autoimmune skin disorder.
Ahmed +53 more
core +1 more source
Frontiers in Immunology, 2023 Autoimmune blistering diseases (AIBD) are paradigms of autoantibody-mediated organ-specific autoimmune disorders that involve skin and/or mucous membranes.
Shirin Emtenani +5 more
doaj +1 more source