T cell autoimmunity and immune regulation to desmoglein 3, a pemphigus autoantigen [PDF]
J Dermatol, 2022 Pemphigus is a life‐threatening autoimmune bullous disease mediated by anti‐desmoglein IgG autoantibodies. Pemphigus is mainly classified into three subtypes: pemphigus vulgaris, pemphigus foliaceus, and paraneoplastic pemphigus.
Hayato Takahashi +2 more
semanticscholar +3 more sources
Immunization with desmoglein 3 induces non-pathogenic autoantibodies in mice. [PDF]
PLoS ONE, 2021 BackgroundPemphigus vulgaris (PV) is a rare autoimmune blistering disease characterized by the development of autoantibodies targeting desmoglein (Dsg) 3, but also against Dsg1 in mucocutaneous disease.
Katharina Boch +10 more
doaj +4 more sources
Stabilization of Keratinocyte Monolayer Integrity in the Presence of Anti-Desmoglein-3 Antibodies through FcRn Blockade with Efgartigimod: Novel Treatment Paradigm for Pemphigus? [PDF]
Cells, 2022 Pemphigus vulgaris is an autoimmune blistering disease of the epidermis, caused by autoantibodies against desmosomal proteins, mainly desmogleins 1 and 3, which induce an impairment of desmosomal adhesion and blister formation. Recent findings have shown
Anna Zakrzewicz +10 more
doaj +3 more sources
Desmoglein 3 contributes to tumorigenicity of pancreatic ductal adenocarcinoma through activating Src–FAK signaling [PDF]
Animal Cells and Systems, 2021 Desmogleins (DSGs), with the ability to link adjacent cells, have been shown to participate in the development of malignancy. DSG3 was up-regulated in various cancers, including lung, head and neck, and esophagus squamous cell carcinoma, which ...
Yimamumaimaitijiang Abula +3 more
doaj +3 more sources
Desmoglein 3 and Keratin 14 for Distinguishing Between Lung Adenocarcinoma and Lung Squamous Cell Carcinoma [PDF]
Onco Targets Ther, 2020 Background Lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) are the leading major histological phenotypes of all non-small cell lung cancer (NSCLC).
Yongping Dong +8 more
semanticscholar +4 more sources
Stat3 regulates desmoglein 3 transcription in epithelial keratinocytes. [PDF]
JCI Insight, 2017 Pemphigus vulgaris (PV) is an epithelial blistering disease caused by autoantibodies to the desmosomal cadherin desmoglein 3 (DSG3). Glucocorticoids improve disease within days by increasing DSG3 gene transcription, although the mechanism for this ...
X. Mao +4 more
semanticscholar +4 more sources
The desmosomal cadherin desmoglein-3 acts as a keratinocyte anti-stress protein via suppression of p53 [PDF]
Cell Death and Disease, 2019 Desmoglein-3 (Dsg3), the Pemphigus Vulgaris (PV) antigen (PVA), plays an essential role in keratinocyte cell–cell adhesion and regulates various signaling pathways involved in the progression and metastasis of cancer where it is upregulated. We show here
Ambreen Rehman +2 more
exaly +3 more sources
Desmoglein 3: A Help or a Hindrance in Cancer Progression? [PDF]
Cancers, 2015 Desmoglein 3 is one of seven desmosomal cadherins that mediate cell-cell adhesion in desmosomes. Desmosomes are the intercellular junctional complexes that anchor the intermediate filaments of adjacent cells and confer strong cell adhesion thus are essential in the maintenance of tissue architecture and structural integrity.
Louise Brown, Hong Wan
europepmc +6 more sources
Binding to the neonatal Fc receptor enhances the pathogenicity of anti-desmoglein-3 antibodies in keratinocytes [PDF]
Frontiers in ImmunologyThe neonatal Fc receptor (FcRn) is important for numerous cellular processes that involve antibody recycling and trafficking. A major function of FcRn is IgG recycling and half-life prolongation, and FcRn blockade results in a reduction of autoantibodies
Anna Zakrzewicz +6 more
doaj +4 more sources
Type 2 T-Cell Responses against Distinct Epitopes of the Desmoglein 3 Ectodomain in Pemphigus Vulgaris [PDF]
Journal of Investigative Dermatology, 2023 Pemphigus vulgaris (PV) is an autoimmune blistering disorder of the skin and/or mucous membranes caused by IgG autoantibodies which predominantly target two transmembrane desmosomal cadherins, desmoglein (Dsg)1 and Dsg3.
Dario Didona +25 more
openalex +2 more sources