Immunization with desmoglein 3 induces non-pathogenic autoantibodies in mice. [PDF]
PLoS ONE, 2021 BackgroundPemphigus vulgaris (PV) is a rare autoimmune blistering disease characterized by the development of autoantibodies targeting desmoglein (Dsg) 3, but also against Dsg1 in mucocutaneous disease.
Katharina Boch +10 more
doaj +8 more sources
Stabilization of Keratinocyte Monolayer Integrity in the Presence of Anti-Desmoglein-3 Antibodies through FcRn Blockade with Efgartigimod: Novel Treatment Paradigm for Pemphigus? [PDF]
Cells, 2022 Pemphigus vulgaris is an autoimmune blistering disease of the epidermis, caused by autoantibodies against desmosomal proteins, mainly desmogleins 1 and 3, which induce an impairment of desmosomal adhesion and blister formation. Recent findings have shown
Anna Zakrzewicz +10 more
doaj +3 more sources
Desmoglein 3 contributes to tumorigenicity of pancreatic ductal adenocarcinoma through activating Src–FAK signaling [PDF]
Animal Cells and Systems, 2021 Desmogleins (DSGs), with the ability to link adjacent cells, have been shown to participate in the development of malignancy. DSG3 was up-regulated in various cancers, including lung, head and neck, and esophagus squamous cell carcinoma, which ...
Yimamumaimaitijiang Abula +3 more
doaj +3 more sources
A New Solid-Phase Immunosorbent for Selective Binding of Desmoglein 3 Autoantibodies in Patients with Pemphigus Vulgaris. [PDF]
Acta Naturae, 2020 Autoantibodies, immunoglobulins G (IgG) against the desmosomal proteins desmogleins 1 and 3, play a significant role in the pathogenesis of pemphigus vulgaris.
Abramova TV, Spilevaya MV, Kubanov AA.
europepmc +4 more sources
Binding to the neonatal Fc receptor enhances the pathogenicity of anti-desmoglein-3 antibodies in keratinocytes [PDF]
Frontiers in ImmunologyThe neonatal Fc receptor (FcRn) is important for numerous cellular processes that involve antibody recycling and trafficking. A major function of FcRn is IgG recycling and half-life prolongation, and FcRn blockade results in a reduction of autoantibodies
Anna Zakrzewicz +6 more
doaj +3 more sources
Desmoglein-3 autoantibodies in tissues of oral lichen planus patients and its correlation with disease severity: case-control study [PDF]
BMC Oral HealthBackground Due to the not fully understood exact pathogenesis of oral lichen planus, the patients receive symptomatic management, rather than a curative treatment.
Doaa Abdelwadood +3 more
doaj +3 more sources
Acantholysis may precede elevation of circulating anti‐desmoglein 3 antibody levels in pemphigus vulgaris presenting with desquamative gingivitis [PDF]
Clinical and Experimental Dental Research, 2019 Pemphigus vulgaris (PV) is an autoimmune, blistering disease that affects the mucosa and skin. The current theory favors the concept that anti‐desmoglein (Dsg) 3 autoimmunity is the only pathogenic event needed to induce acantholysis.
Hiroyasu Endo +8 more
doaj +3 more sources
T cell autoimmunity and immune regulation to desmoglein 3, a pemphigus autoantigen. [PDF]
J Dermatol, 2023 Pemphigus is a life‐threatening autoimmune bullous disease mediated by anti‐desmoglein IgG autoantibodies. Pemphigus is mainly classified into three subtypes: pemphigus vulgaris, pemphigus foliaceus, and paraneoplastic pemphigus.
Takahashi H, Iriki H, Asahina Y.
europepmc +2 more sources
Detection of Desmoglein-3 Auto-Antibodies in Patients with Lichen Planus [PDF]
Egyptian Journal of Medical Research, 2022 There is controversy about the role of auto anti-bodies against desmoglein 3 (Dsg 3) in the pathogenesis of lichen planus (LP). The goal of this study is to detect desmoglein-3 auto-antibodies in lichen planus patients comparted to normal control persons
Abd-El Aziz El-Rifaie +3 more
doaj +2 more sources
Desmoglein-3 induces YAP phosphorylation and inactivation during collective migration of oral carcinoma cells. [PDF]
Mol Oncol, 2022 Alterations of the Hippo–YAP pathway are potential targets for oral squamous cell carcinoma (OSCC) therapy, but heterogeneity in this pathway could be responsible for therapeutic resistance.
Ahmad US, Parkinson EK, Wan H.
europepmc +2 more sources