Immunization with desmoglein 3 induces non-pathogenic autoantibodies in mice. [PDF]
PLoS ONE, 2021 BackgroundPemphigus vulgaris (PV) is a rare autoimmune blistering disease characterized by the development of autoantibodies targeting desmoglein (Dsg) 3, but also against Dsg1 in mucocutaneous disease.
Katharina Boch +10 more
doaj +5 more sources
Binding to the neonatal Fc receptor enhances the pathogenicity of anti-desmoglein-3 antibodies in keratinocytes [PDF]
Frontiers in ImmunologyThe neonatal Fc receptor (FcRn) is important for numerous cellular processes that involve antibody recycling and trafficking. A major function of FcRn is IgG recycling and half-life prolongation, and FcRn blockade results in a reduction of autoantibodies
Anna Zakrzewicz +6 more
doaj +4 more sources
Desmoglein 2 is less important than desmoglein 3 for keratinocyte cohesion. [PDF]
PLoS ONE, 2013 Desmosomes provide intercellular adhesive strength required for integrity of epithelial and some non-epithelial tissues. Within the epidermis, the cadherin-type adhesion molecules desmoglein (Dsg) 1-4 and desmocollin (Dsc) 1-3 build the adhesive core of ...
Eva Hartlieb +5 more
doaj +10 more sources
Detection of Desmoglein-3 Auto-Antibodies in Patients with Lichen Planus [PDF]
Egyptian Journal of Medical Research, 2022 There is controversy about the role of auto anti-bodies against desmoglein 3 (Dsg 3) in the pathogenesis of lichen planus (LP). The goal of this study is to detect desmoglein-3 auto-antibodies in lichen planus patients comparted to normal control persons
Abd-El Aziz El-Rifaie +3 more
doaj +2 more sources
Stabilization of Keratinocyte Monolayer Integrity in the Presence of Anti-Desmoglein-3 Antibodies through FcRn Blockade with Efgartigimod: Novel Treatment Paradigm for Pemphigus? [PDF]
Cells, 2022 Pemphigus vulgaris is an autoimmune blistering disease of the epidermis, caused by autoantibodies against desmosomal proteins, mainly desmogleins 1 and 3, which induce an impairment of desmosomal adhesion and blister formation. Recent findings have shown
Anna Zakrzewicz +10 more
doaj +2 more sources
Evaluation of desmoglein 1 and desmoglein 3 autoantibodies in oral cancer: A pilot study
Journal of Indian Academy of Oral Medicine and Radiology, 2023 Background: Carcinogenesis is a complex multistep process involving alterations at the cellular level. Alteration in cell-to-cell adhesion of oral epithelium plays an important role in carcinogenesis and metastasis.
Pavan Kumar Yellarthi +4 more
doaj +2 more sources
Desmoglein 3 contributes to tumorigenicity of pancreatic ductal adenocarcinoma through activating Src–FAK signaling [PDF]
Animal Cells and Systems, 2021 Desmogleins (DSGs), with the ability to link adjacent cells, have been shown to participate in the development of malignancy. DSG3 was up-regulated in various cancers, including lung, head and neck, and esophagus squamous cell carcinoma, which ...
Yimamumaimaitijiang Abula +3 more
doaj +2 more sources
Factors associated with non-pathogenic antibodies against desmoglein-3 in pemphigus foliaceus [PDF]
Anais Brasileiros de DermatologiaBackground Anti-desmoglein (Dsg)1 is produced in pemphigus foliaceus (PF), affecting exclusively the skin. Pemphigus vulgaris (PV) shows the production of anti-Dsg3 in the mucosal form, and anti-Dsg1 and 3 in the mucocutaneous form.
Sebastian Vernal +5 more
doaj +2 more sources
Desmoglein-3 autoantibodies in tissues of oral lichen planus patients and its correlation with disease severity: case-control study [PDF]
BMC Oral HealthBackground Due to the not fully understood exact pathogenesis of oral lichen planus, the patients receive symptomatic management, rather than a curative treatment.
Doaa Abdelwadood +3 more
doaj +2 more sources
Comparative Transcriptome Analysis Identifies Desmoglein-3 as a Potential Oncogene in Oral Cancer Cells. [PDF]
Cells, 2023 Wan H, Teh MT, Mastroianni G, Ahmad US.
europepmc +3 more sources