Desmoglein 2 is less important than desmoglein 3 for keratinocyte cohesion. [PDF]
PLoS ONE, 2013 Desmosomes provide intercellular adhesive strength required for integrity of epithelial and some non-epithelial tissues. Within the epidermis, the cadherin-type adhesion molecules desmoglein (Dsg) 1-4 and desmocollin (Dsc) 1-3 build the adhesive core of ...
Eva Hartlieb +5 more
doaj +16 more sources
Evaluation of desmoglein 1 and desmoglein 3 autoantibodies in oral cancer: A pilot study
Journal of Indian Academy of Oral Medicine and Radiology, 2023 Background: Carcinogenesis is a complex multistep process involving alterations at the cellular level. Alteration in cell-to-cell adhesion of oral epithelium plays an important role in carcinogenesis and metastasis.
Pavan Kumar Yellarthi +4 more
doaj +3 more sources
Unimpaired skin carcinogenesis in Desmoglein 3 knockout mice. [PDF]
PLoS ONE, 2012 The contribution of adherens junction inactivation, typically by downregulation or mutation of the transmembrane core component E-cadherin, to cancer progression is well recognized.
Sylvain Baron +3 more
doaj +6 more sources
Stat3 regulates desmoglein 3 transcription in epithelial keratinocytes. [PDF]
JCI Insight, 2017 Pemphigus vulgaris (PV) is an epithelial blistering disease caused by autoantibodies to the desmosomal cadherin desmoglein 3 (DSG3). Glucocorticoids improve disease within days by increasing DSG3 gene transcription, although the mechanism for this ...
Mao X +4 more
europepmc +5 more sources
Indian Journal of Dermatology, 2016 Pemphigus vulgaris (PV) is an autoimmune blistering disease elicited by anti-desmoglein (DsG) 3 antibody. Although skin lesions tend to be distributed over the entire body, in some patients, they are confined to a restricted area.
Asuka Yoshifuku +7 more
doaj +5 more sources
Up-regulation of ST18 in pemphigus vulgaris drives a self-amplifying p53-dependent pathomechanism resulting in decreased desmoglein 3 expression. [PDF]
Sci Rep, 2022 Pemphigus vulgaris (PV) is a life-threatening autoimmune mucocutaneous blistering disease which is to a large extent genetically determined, and results, at least in part, from the deleterious activity of autoantibodies directed against desmoglein (DSG)3,
Assaf S +8 more
europepmc +2 more sources
Desmoglein 3: a help or a hindrance in cancer progression? [PDF]
Cancers (Basel), 2015 Desmoglein 3 is one of seven desmosomal cadherins that mediate cell-cell adhesion in desmosomes. Desmosomes are the intercellular junctional complexes that anchor the intermediate filaments of adjacent cells and confer strong cell adhesion thus are essential in the maintenance of tissue architecture and structural integrity.
Brown L, Wan H.
europepmc +11 more sources
Journal of Indian Academy of Oral Medicine and RadiologyBackground: Desmosomal proteins have a fundamental role in cellular adhesion as they not only maintain cellular homeostasis but also regulate cellular activities like proliferation, differentiation, and migration.
Pavan Kumar Yellarthi +4 more
doaj +3 more sources
Evolving Mechanisms in the Pathophysiology of Pemphigus Vulgaris: A Review Emphasizing the Role of Desmoglein 3 in Regulating p53 and the Yes-Associated Protein. [PDF]
Life (Basel), 2021 The immunobullous condition Pemphigus Vulgaris (PV) is caused by autoantibodies targeting the adhesion proteins of desmosomes, leading to blistering in the skin and mucosal membrane.
Rehman A, Huang Y, Wan H.
europepmc +2 more sources
Peripheral tolerance by Treg via constraining OX40 signal in autoreactive T cells against desmoglein 3, a target antigen in pemphigus. [PDF]
Proc Natl Acad Sci U S A, 2021 Significance Immune tolerance is crucial to prevent harmful immune reactions against self-antigens and well operated by central thymic tolerance and peripheral tissue tolerance.
Iriki H +15 more
europepmc +2 more sources