Desmoglein‐3 induces YAP phosphorylation and inactivation during collective migration of oral carcinoma cells [PDF]
Mol Oncol, 2021 Alterations of the Hippo–YAP pathway are potential targets for oral squamous cell carcinoma (OSCC) therapy, but heterogeneity in this pathway could be responsible for therapeutic resistance.
U. Ahmad, E. K. Parkinson, H. Wan
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Evolving Mechanisms in the Pathophysiology of Pemphigus Vulgaris: A Review Emphasizing the Role of Desmoglein 3 in Regulating p53 and the Yes-Associated Protein [PDF]
Life (Basel), 2021 The immunobullous condition Pemphigus Vulgaris (PV) is caused by autoantibodies targeting the adhesion proteins of desmosomes, leading to blistering in the skin and mucosal membrane.
A. Rehman, Yunying Huang, H. Wan
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Up-regulation of ST18 in pemphigus vulgaris drives a self-amplifying p53-dependent pathomechanism resulting in decreased desmoglein 3 expression [PDF]
Sci Rep, 2022 Pemphigus vulgaris (PV) is a life-threatening autoimmune mucocutaneous blistering disease which is to a large extent genetically determined, and results, at least in part, from the deleterious activity of autoantibodies directed against desmoglein (DSG)3,
S. Assaf +8 more
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Monovalent antibody-conjugated lipid-polymer nanohybrids for active targeting to desmoglein 3 of keratinocytes to attenuate psoriasiform inflammation [PDF]
Theranostics, 2021 To improve the treatment of psoriasiform inflammation, we developed actively targeted nanocarriers loaded with the phosphodiesterase 4 inhibitor AN2728.
Zih-chan lin +5 more
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Peripheral tolerance by Treg via constraining OX40 signal in autoreactive T cells against desmoglein 3, a target antigen in pemphigus [PDF]
Proc Natl Acad Sci U S A, 2021 Significance Immune tolerance is crucial to prevent harmful immune reactions against self-antigens and well operated by central thymic tolerance and peripheral tissue tolerance.
H. Iriki +15 more
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Desmoglein 2 is less important than desmoglein 3 for keratinocyte cohesion. [PDF]
PLoS ONE, 2013 Desmosomes provide intercellular adhesive strength required for integrity of epithelial and some non-epithelial tissues. Within the epidermis, the cadherin-type adhesion molecules desmoglein (Dsg) 1-4 and desmocollin (Dsc) 1-3 build the adhesive core of ...
Eva Hartlieb +5 more
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Definitions, 2020 Desmoglein-3 (999 aa, ~108 kDa) is encoded by the human DSG3 gene. This protein plays a role in desmosome-mediated cell-cell adhesion.
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Evaluation of desmoglein 1 and desmoglein 3 autoantibodies in oral cancer: A pilot study
Journal of Indian Academy of Oral Medicine and Radiology, 2023 Background: Carcinogenesis is a complex multistep process involving alterations at the cellular level. Alteration in cell-to-cell adhesion of oral epithelium plays an important role in carcinogenesis and metastasis.
Pavan Kumar Yellarthi +4 more
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Detection of Autoantibodies against Recombinant Desmoglein 1 and 3 Molecules in Patients with Pemphigus vulgaris: Correlation with Disease Extent at the Time of Diagnosis and during Follow-Up [PDF]
Clinical and Developmental Immunology, 2009 The recent availability of cDNA clones for pemphigus antigens has allowed the production of recombinant desmoglein 1 and desmoglein 3 molecules and the development of an ELISA approach in order to determine levels of antibodies to them.
Anna Belloni Fortina +6 more
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A New Solid-Phase Immunosorbent for Selective Binding of Desmoglein 3 Autoantibodies in Patients with Pemphigus Vulgaris [PDF]
Acta Naturae, 2020 Autoantibodies, immunoglobulins G (IgG) against the desmosomal proteins desmogleins 1 and 3, play a significant role in the pathogenesis of pemphigus vulgaris.
T. Abramova, M. V. Spilevaya, A. Kubanov
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