Desmosomal Hyperadhesion Is Accompanied with Enhanced Binding Strength of Desmoglein 3 Molecules. [PDF]
Biophys J, 2020 Intercellular adhesion of keratinocytes depends critically on desmosomes that, during maturation, acquire a hyperadhesive and thus Ca2+ independent state.
Michaela Fuchs +3 more
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Desmoglein-3 autoantibodies in tissues of oral lichen planus patients and its correlation with disease severity: case-control study [PDF]
BMC Oral HealthBackground Due to the not fully understood exact pathogenesis of oral lichen planus, the patients receive symptomatic management, rather than a curative treatment.
Doaa Abdelwadood +3 more
doaj +2 more sources
Unimpaired skin carcinogenesis in Desmoglein 3 knockout mice. [PDF]
PLoS ONE, 2012 The contribution of adherens junction inactivation, typically by downregulation or mutation of the transmembrane core component E-cadherin, to cancer progression is well recognized.
Sylvain Baron +3 more
doaj +4 more sources
Indian Journal of Dermatology, 2016 Pemphigus vulgaris (PV) is an autoimmune blistering disease elicited by anti-desmoglein (DsG) 3 antibody. Although skin lesions tend to be distributed over the entire body, in some patients, they are confined to a restricted area.
Asuka Yoshifuku +7 more
doaj +3 more sources
Factors associated with non-pathogenic antibodies against desmoglein-3 in pemphigus foliaceus [PDF]
Anais Brasileiros de DermatologiaBackground Anti-desmoglein (Dsg)1 is produced in pemphigus foliaceus (PF), affecting exclusively the skin. Pemphigus vulgaris (PV) shows the production of anti-Dsg3 in the mucosal form, and anti-Dsg1 and 3 in the mucocutaneous form.
Sebastian Vernal +5 more
doaj +2 more sources
Evidence for the Desmosomal Cadherin Desmoglein-3 in Regulating YAP and Phospho-YAP in Keratinocyte Responses to Mechanical Forces [PDF]
Int J Mol Sci, 2019 Desmoglein 3 (Dsg3) plays a crucial role in cell-cell adhesion and tissue integrity. Increasing evidence suggests that Dsg3 acts as a regulator of cellular mechanotransduction, but little is known about its direct role in mechanical force transmission ...
Jutamas Uttagomol +10 more
semanticscholar +2 more sources
Anti‐Desmoglein 3 Avidity Correlates Better With Pemphigus Vulgaris Severity Than Anti‐Desmoglein 3 Concentration [PDF]
International Journal of DermatologyBACKGROUND Pemphigus vulgaris (PV) is caused by immunoglobulin G (IgG) autoantibodies targeting desmoglein 3 (Dsg3) and/or desmoglein 1 (Dsg1). While antibody concentration is routinely used to assess disease activity, the role of antibody avidity in PV ...
Branislav Lekić +5 more
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Pemphigus IgG Causes Skin Splitting in the Presence of Both Desmoglein 1 and Desmoglein 3 [PDF]
The American Journal of Pathology, 2007 According to the desmoglein (Dsg) compensation concept, different epidermal cleavage planes observed in pemphigus vulgaris and pemphigus foliaceus have been proposed to be caused by different autoantibody profiles against the desmosomal proteins Dsg 1 and Dsg 3.
Volker Spindler +3 more
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Protection against Pemphigus Foliaceus by Desmoglein 3 in Neonates [PDF]
New England Journal of Medicine, 2000 Pemphigus foliaceus is an autoantibody-mediated blistering disease in which antibodies against desmoglein 1 cause loss of adhesion among keratinocytes in the superficial epidermis.1 Desmogleins are transmembrane glycoproteins found in desmosomes, which provide physical connections between cells.
Hong Wu +10 more
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Treatment-naïve pemphigus patients showing IgG tissuedeposits have serum IgG antibodies against desmoglein 1detected more often than those against desmoglein 3:a monocentre laboratory experience [PDF]
Postepy Dermatol Alergol, 2023 Magdalena Jałowska +3 more
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