Monovalent antibody-conjugated lipid-polymer nanohybrids for active targeting to desmoglein 3 of keratinocytes to attenuate psoriasiform inflammation. [PDF]
Theranostics, 2021 To improve the treatment of psoriasiform inflammation, we developed actively targeted nanocarriers loaded with the phosphodiesterase 4 inhibitor AN2728.
Lin ZC +5 more
europepmc +2 more sources
Desmoglein 3 and Keratin 14 for Distinguishing Between Lung Adenocarcinoma and Lung Squamous Cell Carcinoma. [PDF]
Onco Targets Ther, 2020 Background Lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) are the leading major histological phenotypes of all non-small cell lung cancer (NSCLC).
Dong Y +8 more
europepmc +2 more sources
Rituximab in pemphigus foliaceous with autoantibodies against both Desmoglein 1 and Desmoglein 3 [PDF]
European Journal of Dermatology, 2011 ejd.2011.1288 Auteur(s) : Rodrigo CARVALHO1 rodrigoaraujocarvalho@gmail.com, Paula MAIO1, Daniela CUNHA1, Isabel FREITAS1, Ana AFONSO2, Jorge CARDOSO1 1 Department of Dermatology and Venereology, Curry Cabral Hospital, Lisbon, Portugal 2 Department of Pathology, Curry Cabral Hospital, Lisbon, Portugal Reprints.: R. CARVALHO Pemphigus foliaceous (PF) is
Isabel Freitas +5 more
openaire +4 more sources
Factors associated with non-pathogenic antibodies against desmoglein-3 in pemphigus foliaceus [PDF]
Anais Brasileiros de DermatologiaBackground Anti-desmoglein (Dsg)1 is produced in pemphigus foliaceus (PF), affecting exclusively the skin. Pemphigus vulgaris (PV) shows the production of anti-Dsg3 in the mucosal form, and anti-Dsg1 and 3 in the mucocutaneous form.
Sebastian Vernal +5 more
doaj +2 more sources
Detection of Autoantibodies against Recombinant Desmoglein 1 and 3 Molecules in Patients with Pemphigus vulgaris: Correlation with Disease Extent at the Time of Diagnosis and during Follow-Up [PDF]
Clinical and Developmental Immunology, 2009 The recent availability of cDNA clones for pemphigus antigens has allowed the production of recombinant desmoglein 1 and desmoglein 3 molecules and the development of an ELISA approach in order to determine levels of antibodies to them.
Anna Belloni-Fortina +6 more
doaj +4 more sources
Evidence for the Desmosomal Cadherin Desmoglein-3 in Regulating YAP and Phospho-YAP in Keratinocyte Responses to Mechanical Forces. [PDF]
Int J Mol Sci, 2019 Desmoglein 3 (Dsg3) plays a crucial role in cell-cell adhesion and tissue integrity. Increasing evidence suggests that Dsg3 acts as a regulator of cellular mechanotransduction, but little is known about its direct role in mechanical force transmission ...
Uttagomol J +10 more
europepmc +2 more sources
The desmosomal cadherin desmoglein-3 acts as a keratinocyte anti-stress protein via suppression of p53. [PDF]
Cell Death Dis, 2019 Desmoglein-3 (Dsg3), the Pemphigus Vulgaris (PV) antigen (PVA), plays an essential role in keratinocyte cell–cell adhesion and regulates various signaling pathways involved in the progression and metastasis of cancer where it is upregulated. We show here
Rehman A +15 more
europepmc +2 more sources
858 Desmoglein 3 acts as a mechanosensor in keratinocytes [PDF]
Journal of Investigative Dermatology, 2018 Jutamas Uttagomol +3 more
semanticscholar +4 more sources
Generation of an anti-desmoglein 3 antibody without pathogenic activity of pemphigus vulgaris for therapeutic application to squamous cell carcinoma. [PDF]
J Biochem, 2018 &NA; It is ideal for the target antigen of a cytotoxic therapeutic antibody against cancer to be cancer‐specific, but such antigens are rare. Thus an alternative strategy for target selection is necessary.
Funahashi SI +7 more
europepmc +2 more sources
Immunoadsorption of Desmoglein-3-Specific IgG Abolishes the Blister-Inducing Capacity of Pemphigus Vulgaris IgG in Neonatal Mice. [PDF]
Front Immunol, 2018 Pemphigus vulgaris (PV) is a potentially life-threatening autoimmune blistering disease which is associated with autoantibodies directed against two desmosomal proteins, desmoglein (Dsg) 3 and 1.
Hofrichter M +10 more
europepmc +2 more sources