Galectin-3 Regulates Desmoglein-2 and Intestinal Epithelial Intercellular Adhesion [PDF]
Journal of Biological Chemistry, 2014 The desmosomal cadherins, desmogleins, and desmocollins mediate strong intercellular adhesion. Human intestinal epithelial cells express the desmoglein-2 isoform. A proteomic screen for Dsg2-associated proteins in intestinal epithelial cells identified a lectin referred to as galectin-3 (Gal3).
Kun Jiang +8 more
openalex +4 more sources
Attenuation of OX40 signaling suppression by age disrupts peripheral deletion of CD4+ T cells specific for the epidermal autoantigen desmoglein 3 [PDF]
Immun Ageing, 2023 Hisato Iriki +6 more
openalex +2 more sources
Plakophilin 1 but not plakophilin 3 regulates desmoglein clustering
Cellular and Molecular Life Sciences, 2019 Plakophilins (Pkp) are desmosomal plaque proteins crucial for desmosomal adhesion and participate in the regulation of desmosomal turnover and signaling. However, direct evidence that Pkps regulate clustering and molecular binding properties of desmosomal cadherins is missing. Here, keratinocytes lacking either Pkp1 or 3 in comparison to wild type (wt)
Michael Fuchs +8 more
openalex +4 more sources
Immunoadsorption of Desmoglein-3-Specific IgG Abolishes the Blister-Inducing Capacity of Pemphigus Vulgaris IgG in Neonatal Mice [PDF]
Front Immunol, 2018 Pemphigus vulgaris (PV) is a potentially life-threatening autoimmune blistering disease which is associated with autoantibodies directed against two desmosomal proteins, desmoglein (Dsg) 3 and 1.
M. Hofrichter +10 more
semanticscholar +2 more sources
Faster IgG4 Depletion Kinetics Observed for Anti-Desmoglein 3 Autoantibodies Following Rituximab Treatment in Patients with Pemphigus Vulgaris [PDF]
Acta Derm Venereol, 2022 Katharina Boch +8 more
openalex +3 more sources
Desmoglein 3-Reactive B Cells "Hiding" in Pemphigus Lesions. [PDF]
Journal of Investigative Dermatology, 2017 Pemphigus vulgaris is an autoimmune blistering disease caused by anti-desmoglein 3 IgG autoantibodies. It is accepted that interactions between autoreactive B and T cells are key to humoral autoimmunity targeting desmoglein 3. This orchestrated process usually occurs in secondary lymphoid organs, including the spleen and lymph nodes.
Hayato Takahashi
semanticscholar +3 more sources
Desmoglein 3 – Influence on oral carcinoma cell migration and invasion
Experimental Cell Research, 2018 &NA; Desmoglein 3 (Dsg3) is an adhesion receptor in desmosomes, but its role in carcinoma cell migration and invasion is mostly unknown. Our aim was to quantitatively analyse the motion of Dsg3‐modified carcinoma cells in 2D settings and in 3D within ...
Ehsanul Hoque Apu +4 more
semanticscholar +6 more sources
Desmoglein 3 regulates membrane trafficking of cadherins, an implication in cell-cell adhesion [PDF]
Cell Adh Migr, 2017 E-cadherin mediated cell-cell adhesion plays a critical role in epithelial cell polarization and morphogenesis. Our recent studies suggest that the desmosomal cadherin, desmoglein 3 (Dsg3) cross talks with E-cadherin and regulates its adhesive function ...
Hanan S. Moftah +7 more
semanticscholar +2 more sources
Evaluation of anti-desmoglein-1 and anti-desmoglein-3 autoantibody titers in pemphigus patients at the time of the initial diagnosis and after clinical remission [PDF]
Medicine (Baltimore), 2017 It has been suggested that anti-desmoglein autoantibody titers could be helpful in follow-up and therapeutic management of pemphigus patients. However, there is no consensus regarding the relationship between anti-desmoglein autoantibody titers and ...
I. Russo +3 more
semanticscholar +2 more sources
Acantholysis may precede elevation of circulating anti‐desmoglein 3 antibody levels in pemphigus vulgaris presenting with desquamative gingivitis [PDF]
Clinical and Experimental Dental Research, 2019 Pemphigus vulgaris (PV) is an autoimmune, blistering disease that affects the mucosa and skin. The current theory favors the concept that anti‐desmoglein (Dsg) 3 autoimmunity is the only pathogenic event needed to induce acantholysis.
Hiroyasu Endo +8 more
doaj +2 more sources