Determining the potential of desmoglein 3 as a sensitive and specific immunohistochemical marker for the detection of micrometastasis in patients with primary oral squamous cell carcinoma [PDF]
Contemporary Oncology, 2016 Aim of the study : Despite advances in surgical and radiotherapy techniques, the presence of lymph node metastasis drastically decreases the survival rate of patients with primary oral squamous cell carcinoma (OSCC).
Shruti Nagvekar +2 more
doaj +2 more sources
Loss of flotillin expression results in weakened desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes [PDF]
Scientific Reports, 2016 Desmosomes are adhesion plaques that mediate cell-cell adhesion in many tissues, including the epidermis, and generate mechanical resistance to tissues. The extracellular domains of desmosomal cadherin proteins, desmogleins and desmocollins, are required
F. Völlner +7 more
semanticscholar +3 more sources
Definitions, 2020 Desmoglein-3 (999 aa, ~108 kDa) is encoded by the human DSG3 gene. This protein plays a role in desmosome-mediated cell-cell adhesion.
semanticscholar +2 more sources
Desmoglein 3 regulates membrane trafficking of cadherins, an implication in cell-cell adhesion. [PDF]
Cell Adh Migr, 2017 E-cadherin mediated cell-cell adhesion plays a critical role in epithelial cell polarization and morphogenesis. Our recent studies suggest that the desmosomal cadherin, desmoglein 3 (Dsg3) cross talks with E-cadherin and regulates its adhesive function ...
Moftah H +7 more
europepmc +2 more sources
Expression of Desmoglein 1 Compensates for Genetic Loss of Desmoglein 3 in Keratinocyte Adhesion [PDF]
Journal of Investigative Dermatology, 2002 The desmoglein compensation hypothesis, namely that one desmoglein can compensate for loss of function of another, has been proposed to explain the tissue specificity of the autoantibody-induced loss of cell adhesion in pemphigus. To validate this hypothesis genetically, we used desmoglein-3 knockout mice (DSG3-/-) that lose their telogen hair ...
Yasushi Hanakawa +2 more
openalex +4 more sources
Evaluation of anti-desmoglein-1 and anti-desmoglein-3 autoantibody titers in pemphigus patients at the time of the initial diagnosis and after clinical remission. [PDF]
Medicine (Baltimore), 2017 It has been suggested that anti-desmoglein autoantibody titers could be helpful in follow-up and therapeutic management of pemphigus patients. However, there is no consensus regarding the relationship between anti-desmoglein autoantibody titers and ...
Russo I +3 more
europepmc +2 more sources
Journal of Contemporary Dental Practice, 2018 AIM The current study will attempt to throw light on the role of desmoglein 1 and desmoglein 3 in the pathogenesis of erosive lichen planus and their response to topical application of tacrolimus. MATERIALS AND METHODS Twenty patients with erosive oral
Islam Saad, Suzan Salem
openalex +2 more sources
IgA pemphigus showing IgA antibodies to desmoglein 1 and 3 [PDF]
Dermatology Practical & Conceptual, 2016 Background: IgA pemphigus is a rare autoimmune vesiculo-pustular skin disease. Only approximately 70 cases have been reported to date. We report a case of IgA pemphigus with IgA antibodies to desmoglein 1 (Dsg1) and desmoglein 3 (Dsg3).
Salama Hegazy +5 more
doaj +3 more sources
Desmosomal Hyperadhesion Is Accompanied with Enhanced Binding Strength of Desmoglein 3 Molecules. [PDF]
Biophys J, 2020 Fuchs M +3 more
europepmc +2 more sources
Circulating Antibodies Against DSG1 and DSG3 in Patients with Oral Lichen Planus: A Scoping Review [PDF]
AntibodiesOral Lichen Planus (OLP) is a chronic autoimmune disease with potential overlap with Pemphigus Vulgaris (PV), particularly in erosive forms. Desmoglein 1 and 3 are transmembrane glycoproteins of desmosomes, typically involved in PV.
Domenico De Falco +5 more
doaj +2 more sources