Results 41 to 50 of about 16,279,763 (246)

Correction: Zakrzewicz et al. Stabilization of Keratinocyte Monolayer Integrity in the Presence of Anti-Desmoglein-3 Antibodies through FcRn Blockade with Efgartigimod: Novel Treatment Paradigm for Pemphigus? Cells 2022, 11, 942. [PDF]

Cells, 2022
Zakrzewicz A, Würth C, Beckert B, Feldhoff S, Vanderheyden K, Foss S, Andersen JT, Haard H, Verheesen P, Bobkov V, Tikkanen R.   +10 more
europepmc   +3 more sources

Desmoglein 3 (Dsg3) expression in cancer: A tissue microarray study on 15,869 tumors

Pathology, Research and Practice, 2022
Florian Viehweger, Ahmad Azem, Natalia Gorbokon, Ria Uhlig, Maximilian Lennartz, Sebastian Dwertmann Rico, Simon Kind, Viktor Reiswich, Martina Kluth, Claudia Hube‐Magg, Christian Bernreuther, Franziska Büscheck, Till S. Clauditz, Christoph Fraune, Frank Jacobsen, Till Krech, Patrick Lebok, Stefan Steurer, Eike Burandt, Sarah Minner, Andreas Marx, Ronald Simon, Guido Sauter, Anne Menz, Andrea Hinsch   +24 more
openalex   +2 more sources

T Lymphocytes from a Subset of Patients with Pemphigus Vulgaris Respond to Both Desmoglein-3 and Desmoglein-1

Journal of Investigative Dermatology, 1997
Pemphigus vulgaris and pemphigus foliaceus are cutaneous autoimmune diseases characterized by intraepithelial blisters and autoantibodies to desmosomal glycoproteins. The antigens recognized by pemphigus vulgaris and pemphigus foliaceus autoantibodies are desmoglein-3 (Dsg3) and desmoglein-1 (Dsg1), respectively.
Mong-Shang Lin, Sue J. Swartz, Argelia Lopez, Xiang Ding, Janet A. Fairley, Luis A. Díaz   +5 more
openalex   +4 more sources

Desmoglein autoantibodies and disease severity in pemphigus patients – correlations and discrepancies [PDF]

Folia Medica, 2023
Aim: To assess the correlation between the levels of anti-desmoglein-1 and anti-desmoglein-3 autoantibodies and disease severity in pemphigus patients.
Zhaneta H. Zhelyazkova, Tsvetana I. Abadjieva, Petya A. Gardjeva, Mariana A. Murdjeva, Tsonka M. Miteva-Katrandzhieva   +4 more
doaj   +3 more sources

A Subset of Pemphigus Foliaceus Patients Exhibits Pathogenic Autoantibodies Against Both Desmoglein-1 and Desmoglein-3 [PDF]

Journal of Investigative Dermatology, 2002
In pemphigus vulgaris the major pathogenic antibody binds desmoglein-3, and mediates mucosal disease. Development of cutaneous disease is associated with acquisition of antibodies to desmoglein-1. In pemphigus foliaceus, and its endemic form, fogo selvagem by contrast, the major pathogenic antibody recognizes desmoglein-1 and mediates cutaneous disease
Luis Arteaga, Philip Prisayanh, Simon Warren, Zhi Liu, Luis A. Díaz, Mong-Shang Lin   +5 more
openalex   +5 more sources

Prognostic Significance of Desmoglein 2 and Desmoglein 3 in Esophageal Squamous Cell Carcinoma [PDF]

Asian Pacific Journal of Cancer Prevention, 2014
Desmogleins (DSGs) are major members among the desmosomal cadherins critically involved in cell-cell adhesion and the maintenance of normal tissue architecture in epithelia. Reports exploring links of DSG family member expression with cancers are few and vary.
Wang‐Kai Fang, Wei Gu, Lian‐Di Liao, Bo Chen, Zhi‐Yong Wu, Jian‐Yi Wu, Jian Shen, Li‐Yan Xu, En‐Min Li   +8 more
openalex   +4 more sources

Protection against Pemphigus Foliaceus by Desmoglein 3 in Neonates [PDF]

New England Journal of Medicine, 2000
Pemphigus foliaceus is an autoantibody-mediated blistering disease in which antibodies against desmoglein 1 cause loss of adhesion among keratinocytes in the superficial epidermis.1 Desmogleins are transmembrane glycoproteins found in desmosomes, which provide physical connections between cells.
Hong Wu, Zhi Hong Wang, Albert C. Yan, Stephen Lyle, Steven Fakharzadeh, James K. Wahl, Margaret J. Wheelock, Hiroshi Ishikawa, Jouni Uitto, Masayuki Amagai, John R. Stanley   +10 more
openalex   +3 more sources

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

IgM to IgG Class Switching Is a Necessary Step for Pemphigus Phenotype Induction in Desmoglein 3–Specific B Cell Receptor Knock-in Mouse

Journal of Immunology, 2022
Key Points Class switch did not occur in Dsg3-specific BCR knock-in mice in a steady state. Stimulation driving anti-Dsg3 IgG production induced a pemphigus phenotype in mice.
H. Nomura, N. Wada, Hayato Takahashi, Y. Kase, J. Yamagami, S. Egami, H. Iriki, M. Mukai, A. Kamata, Hiromi Ito, Hideki Fujii, Tomoyuki Ishikura, H. Koseki, Takashi Watanabe, Taketo Yamada, O. Ohara, S. Koyasu, M. Amagai   +17 more
semanticscholar   +1 more source

Differential Effects of Desmoglein 1 and Desmoglein 3 on Desmosome Formation [PDF]

Journal of Investigative Dermatology, 2002
The desmoglein plays an important part in the formation of desmosomes. We constructed recombinant adenoviruses containing desmoglein 1 and desmoglein 3 derivatives partly lacking the extracellular domain (desmoglein 1DeltaEC and desmoglein 3DeltaEC, respectively), and full-length desmoglein 1 and desmoglein 3 and studied the involvement of desmoglein 1
Koji Sayama, Yoko Yahata, Masayuki Amagai, Mikiko Tohyama, Yuji Shirakata, Sho Tokumaru, Koji Hashimoto, Kenshi Yamasaki, Yasushi Hanakawa   +8 more
openaire   +3 more sources