Results 41 to 50 of about 13,115 (209)

YAP Inhibition by Verteporfin Causes Downregulation of Desmosomal Genes and Proteins Leading to the Disintegration of Intercellular Junctions

Life, 2022
The Hippo-YAP pathway serves as a central signalling hub in epithelial tissue generation and homeostasis. Yes-associated protein (YAP) is an essential downstream transcription cofactor of this pathway, with its activity being negatively regulated by ...
Yunying Huang, Usama Sharif Ahmad, Ambreen Rehman, Jutamas Uttagomol, Hong Wan   +4 more
doaj   +1 more source

Isolated perineal plaque as the initial presentation of pemphigus vulgaris [PDF]

JAAD Case Reports
Aster Workineh, MPH, Gauri Panse, MD, Mary Tomayko, MD, PhD, Alicia J. Little, MD, PhD   +3 more
doaj   +2 more sources

Involvement of Nail Apparatus in Pemphigus Vulgaris in Ethnic Poles Is Infrequent

Frontiers in Medicine, 2018
Pemphigus vulgaris lesions have a tendency to localize around natural body orifices. The aim here was to analyze the involvement of nail apparatus in pemphigus vulgaris.
Pawel Pietkiewicz, Pawel Pietkiewicz, Monika Bowszyc-Dmochowska, Justyna Gornowicz-Porowska, Marian Dmochowski   +4 more
doaj   +1 more source

Case report: Documentation of cutaneous only pemphigus vulgaris without history of mucosal lesions in North America

Frontiers in Immunology, 2022
BackgroundPemphigus is a group of autoimmune blistering diseases including Pemphigus vulgaris (PV) and Pemphigus foliaceus (PF). These conditions exhibit lesions with mucosal or mucocutaneous (PV) or cutaneous (PF) morphology, as framed by the Desmoglein
John Baker, Kristina Seiffert-Sinha, Animesh A. Sinha   +2 more
doaj   +1 more source

Protease inhibitors prevent plasminogen-mediated, but not pemphigus vulgaris-induced, acantholysis in human epidermis [PDF]

, 2003
Pemphigus is an autoimmune blistering disease of the skin and mucous membranes. It is caused by autoantibodies directed against desmosomes, which are the principal adhesion structures between epidermal keratinocytes.
Besch, R., Braungart, E., Degitz, K., Douwes, K., Flaig, M. J., Magdolen, V., Probst, C., Sander, C. A., Schuh, T., Wosikowski, K.   +9 more
core   +1 more source

Mutations in desmoglein-1 cause diverse inherited palmoplantar keratoderma phenotypes:implications for genetic screening [PDF]

, 2017
INTRODUCTION: The inherited palmoplantar keratodermas (PPKs) are a heterogeneous group of genodermatoses, characterised by thickening of the epidermis of the palms and soles. No classification system unites satisfactorily clinical presentation, pathology
Almutawa, Armstrong, Dua-Awereh, Harmon, Has, Hershkovitz, Hunt, Irvine, Itin, Keren, Klijuic, McAleer, Milingou, Nomura, Samuelov, Wan, Whittock   +16 more
core   +2 more sources

Is transition between subtypes of pemphigus possible? A series of pemphigus vulgaris patients showing the transition to pemphigus foliaceus

Anais Brasileiros de Dermatologia, 2023
Background Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are subtypes of pemphigus with distinct clinical and laboratory features. The transition between these two subtypes has rarely been reported previously.
Rifkiye Kucukoglu, Tugba Atci, Gizem Pinar Sun   +2 more
doaj   +1 more source

Sudden cardiac death in young athletes: Literature review of molecular basis [PDF]

, 2020
Intense athletic training and competition can rarely result in sudden cardiac death (SCD). Despite the introduction of pre-participation cardiovascular screening, especially among young competitive athletes, sport-related SCD remains a debated issue ...
Barbara Lombardo, Bruno Mirra, Cristina Mazzaccara, Ferdinando Barretta, Giulia Frisso, Olga Scudiero   +5 more
core   +1 more source

The mapping of linear B-cell epitope regions in desmoglein 1 and 3 proteins : Recognition of immobilized peptides by pemphigus patients’ serum autoantibodies [PDF]

, 2013
Desmosomal transmembrane glycoproteins desmoglein 1and desmoglein 3 are targets of life-threatening autoimmune blistering disorders such as Pemphigus vulgaris (PV) and Pemphigus foliaceus(PF).
Bősze, Szilvia, Hudecz, Ferenc, Kárpáti, Sarolta, Silló, Pálma, Szabados, Hajnalka, Uray, Katalin   +5 more
core   +1 more source

Limbal stem cell transplantation: clinical results, limits, and perspectives [PDF]

, 2018
Limbal stem cell deficiency (LSCD) is a clinical condition characterized by damage of cornea limbal stem cells, which results in an impairment of corneal epithelium turnover and in an invasion of the cornea by the conjunctival epithelium.
Bruscolini, Alice, Lambiase, Alessandro, Rama, Paolo, Sacchetti, Marta   +3 more
core   +1 more source