Results 51 to 60 of about 13,115 (209)

The many faces of Aire in central tolerance

Frontiers in Immunology, 2013
Although the role that Autoimmune Regulator (Aire) plays in the induction of central tolerance is well known, the precise cellular and molecular mechanisms are still unclear and debated.
Martti eLaan, Pärt ePeterson
doaj   +1 more source

Characterization of Desmoglein-3 Epitope Region Peptides as Synthetic Antigens: Analysis of their in vitro T-cell Stimulating Efficacy, Cytotoxicity, Stability and their Conformational Features [PDF]

, 2015
Desmoglein-3 (Dsg3) adhesion protein is the main target of autoantibodies and autoreactive T cells in Pemphigus vulgaris (PV) autoimmune skin disorder.
Ahmed, Ahmed, Amagai, Amagai, Amber, Anhalt, Berkower, Carmicle, Chou, Delva, Dworschak, Enyedi, Estaquier, Ferrante, Green, Gómara, Hashimoto, Hertl, Holly, Hollósi, Jurcevic, Lin, Mahoney, Manning, Meager, Moesta, Mosmann, Partidos, Povey, Rammensee, Riechers, Ruocco, Sathyanarayana, Scharf, Scharf, Schiltz, Shanmugam, Siddiqui, Siligardi, Slater, Stanley, Sz, Szabados, Thomason, Toniolo, Vass, Veldman, Watts, Wheeler, Woody, Woody, Wucherpfennig, Wucherpfennig, Yang   +53 more
core   +1 more source

The Diversity of Serum Anti-DSG3 IgG Subclasses Has a Major Impact on Pemphigus Activity and Is Predictive of Relapses After Treatment With Rituximab

Frontiers in Immunology, 2022
IntroductionWe studied the distribution and in vitro pathogenicity of anti-DSG3 IgG subclasses during the course of pemphigus vulgaris (PV).MethodsWe longitudinally studied the distribution of anti-DSG3 IgG subclasses (before versus after treatment) in ...
Marie-Laure Golinski, Alexandre Lemieux, Maud Maho-Vaillant, Marion Barray, Laurent Drouot, Damien Schapman, Marie Petit, Michael Hertl, Olivier Boyer, Sébastien Calbo, Pascal Joly, Vivien Hébert   +11 more
doaj   +1 more source

Non-classical forms of pemphigus: pemphigus herpetiformis, IgA pemphigus, paraneoplastic pemphigus and IgG/IgA pemphigus [PDF]

, 2014
The pemphigus group comprises the autoimmune intraepidermal blistering diseases classically divided into two major types: pemphigus vulgaris and pemphigus foliaceous.
Adriana Maria Porro, Amagai M, Amagai M, Amagai M, Amagai M, Amagai M, Anhalt GJ, Anhalt GJ, Arranz D, Asahina A, Barrance VP, Beutner EH, Borradori L, Bruckner AL, Bull RH, Buxton RS, Camisa C, Chan LS, Chan LS, Chorzelski TP, Chorzelski TP, Cozzani E, Cunha PR, Czernik A, DeMento FJ, Duarte IB, Durham A, Düker I, Emmerson RW, Fang Y, Feng SY, Fernandes IC, Floden CH, Fullerton SH, Gengoux P, Gooptu C, Gruss C, Hashimoto T, Hashimoto T, Hashimoto T, Hashimoto T, Hashimoto T, Hashimoto T, Hashimoto T, Heng A, Hertl M, Hodak E, Horn TD, Hosoda S, Howell SM, Huff JC, Huhn KM, Iida K, Ingber A, Inui S, Ishii K, Ishii N, Jablonska S, Kaplan I, Kimyai-Asadi A, Kitajima Y, Kopp T, Kowalewski C, Kozlowska A, Kubo A, Kubota Y, Laura de Sena Nogueira Maehara, Lebeau S, Leger S, Leithauser LA, Liu Q, Livia de Vasconcelos Nasser Caetano, Lu Y, Lutz ME, Maciejowska E, Maldonado F, Marinovic B, Martel P, Maruyama H, Marzano AV, Mentink LF, Micali G, Miida H, Milvia Maria dos Santos Enokihara, Mimouni D, Mimouni D, Miura T, Miyagawa S, Miyagawa S, Morita E, Morizane S, Moutran R, Müller R, Nakajima K, Nakashima H, Nguyen VT, Nishikawa T, Nousari HC, Nousari HC, O'Toole EA, Ohata C, Ohyama B, Oiso N, Palleschi GM, Patrício P, Prado R, Qian SX, Robinson ND, Ruiz-Genao DP, Sanchez-Palacios C, Santi CG, Santiago-et-Sánchez-Mateos D, Schepens I, Seah PP, Sklavounou A, Sneddon I, Sneddon IB, Szturz P, Tagami H, Taintor AR, Tajima M, Tateishi C, Tsuruta D, Verdier-Sevrain S, Wakahara M, Wallach D, Wallach D, Wang J, Wang J, Weston WL, Yasuda H, Zaraa I, Zaraa I, Zhu X, Zimmermann J   +134 more
core   +4 more sources

Reduced Dietary Protein Induces Changes in the Dental Proteome

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Low dietary protein (10%) from normal (20%) does change protein expression in tooth proteome and alter developmental pathways. Among the significant protein expressions changes are actin‐based myosins, tooth, and bone development proteins. Perplexingly tooth size is not altered, suggesting more nuanced phenotypic response to low dietary protein in ...
Robert W. Burroughs, Christopher J. Percival, Natasha S. Vitek   +2 more
wiley   +1 more source

Bullous pemphigoid associated with milia, increased serum IgE, autoantibodies against desmogleins, and refractory treatment in a young patient [PDF]

Anais Brasileiros de Dermatologia, 2017
: Bullous pemphigoid is a blistering autoimmune disease characterized by two hemidesmosomal proteins (anti-BP180 and 230). Pemphigus, by contrast, is characterized by two autoantibodies (anti-desmoglein 1 and 3).
Shu Ding, Qiancheng Deng, Yaping Xiang, Jing Chen, Jinhua Huang, Jianyun Lu   +5 more
doaj   +1 more source

The cell-cell junctions of mammalian testes: I. The adhering junctions of the seminiferous epithelium represent special differentiation structures [PDF]

, 2014
The seminiferous tubules and the excurrent ducts of the mammalian testis are physiologically separated from the mesenchymal tissues and the blood and lymph system by a special structural barrier to paracellular translocations of molecules and particles ...
Domke, Lisa M., Dörflinger, Yvette, Franke, Werner W., Heid, Hans, Kuhn, Caecilia, Rickelt, Steffen, Rosin-Arbesfeld, Rina, Winter-Simanowski, Stefanie, Zimbelmann, Ralf   +8 more
core   +2 more sources

Detection of anti-desmoglein antibodies in oral lichen planus: What do we know so far

Frontiers in Immunology, 2022
Oral lichen planus (OLP) is an inflammatory disease of the oral mucosa. Clinically, two main subsets are described, namely non-erosive and erosive OLP. While non-erosive OLP is usually responsive to local therapies, erosive OLP is often refractory also ...
Dario Didona, Michael Hertl
doaj   +1 more source

Significance of epitope spreading in the pathogenesis of pemphigus vulgaris and foliaceus [PDF]

, 2008
Os pênfigos são dermatoses bolhosas auto-imunes, em que há a produção de auto-anticorpos direcionados contra moléculas de adesão dos epitélios, levando à perda da coesão celular.
AOKI, Valéria, LAGO, Fernanda, MARUTA, Celina Wakisaka, SANTI, Cláudia Giuli, The Cooperative Group on Fogo Selvagem Research, YAMAZAKI, Márcia Harumi   +5 more
core   +2 more sources

Paraneoplastic pemphigus: insight into the autoimmune pathogenesis, clinical features and therapy [PDF]

, 2017
Paraneoplastic pemphigus is a rare autoimmune skin disease that is always associated with a neoplasm. Usually, oral, skin, and mucosal lesions are the earliest manifestations shown by paraneoplastic pemphigus patients.
Andrea Ciofalo, Biagio Didona, Bialy-Golan, Dario Didona, Elisa Moliterni, Giannicola Iannella, Giovanni Paolino, Giuseppe Magliulo, Guido Granata, Hainsworth, Martínez De Pablo, Matz, Michele Donati, Mutasim, Nguyen, Patricia Ranuzzi, Santo Mercuri, Schepens, Stefano Calvieri, Su, Vincenzo Falasca, Zimmermann   +21 more
core   +2 more sources