Frontiers in Immunology, 2023 Pemphigus vulgaris (PV) is an acquired autoimmune blistering disease characterized by the production of autoantibodies targeting desmosomal cadherins, primarily desmoglein 1 and desmoglein 3, leading to acantholysis. The etiology of PV is multifactorial,
Ines Lakoš Jukić +4 more
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Desmoglein 1 and Desmoglein 3 Are the Target Autoantigens in Herpetiform Pemphigus [PDF]
Archives of Dermatology, 1999 To determine the cell surface autoimmune target of herpetiform pemphigus (HP).Serum samples of HP were examined by immunoblot studies with human epidermal extracts, enzyme-linked immunosorbent assay with baculovirus-expressed recombinant desmoglein (rDsg) 1 and rDsg3, and immunoadsorption assay with rDsg.Twenty serum samples were obtained from patients
Takashi Hashimoto +8 more
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Determinants of VH1-46 Cross-Reactivity to Pemphigus Vulgaris Autoantigen Desmoglein 3 and Rotavirus Antigen VP6. [PDF]
J Immunol, 2016 Cho MJ +8 more
europepmc +2 more sources
Efficacy of Rituximab in Patients with Autoimmune Bullous Disease: A Retrospective Cohort Study
Van Tıp Dergisi, 2021 INTRODUCTION: The aim of this study was to evaluate the effectiveness of rituximab in autoimmune bullous diseases. METHODS: In this study, the data of patients who received rituximab treatment for autoimmune bullous disease in our clinic between 2012 and
Özge Aşkın +3 more
doaj +1 more source
Clinical periodontal diagnosis
Periodontology 2000, EarlyView., 2023 Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi +5 more
wiley +1 more source
Suppression of the Immune Response Against Exogenous Desmoglein 3 in Desmoglein 3 Knockout Mice: An Implication for Gene Therapy [PDF]
Journal of Investigative Dermatology, 2003 Gene therapies for recessive genetic diseases may provoke unwanted immune responses against the introduced gene product because patients, especially those with null mutation of a certain protein, have no tolerance for the protein of interest. This study used desmoglein 3 knockout (Dsg3-/-) mice as a disease model for a genetic defect in DSG3, to ...
Masayuki Amagai +7 more
openaire +3 more sources
Desmoglein 3 – Influence on oral carcinoma cell migration and invasion
Experimental Cell Research, 2018 Desmoglein 3 (Dsg3) is an adhesion receptor in desmosomes, but its role in carcinoma cell migration and invasion is mostly unknown. Our aim was to quantitatively analyse the motion of Dsg3-modified carcinoma cells in 2D settings and in 3D within tumour microenvironment mimicking (TMEM) matrices.
Ehsanul Hoque Apu +4 more
semanticscholar +7 more sources
Pemphigus IgG Causes Skin Splitting in the Presence of Both Desmoglein 1 and Desmoglein 3 [PDF]
The American Journal of Pathology, 2007 According to the desmoglein (Dsg) compensation concept, different epidermal cleavage planes observed in pemphigus vulgaris and pemphigus foliaceus have been proposed to be caused by different autoantibody profiles against the desmosomal proteins Dsg 1 and Dsg 3.
Volker Spindler +3 more
openaire +3 more sources
The value of trichoscopy in the differential diagnosis of scalp lesions in pemphigus vulgaris and pemphigus foliaceus [PDF]
Anais Brasileiros de Dermatologia, 2014 BACKGROUND: Trichoscopy is becoming increasingly popular in diagnosing hair and scalp diseases. Scalp involvement in pemphigus is common. The scalp may be the first or only site of clinical manifestation of the disease.
Marta Sar-Pomian +3 more
doaj +2 more sources
Palmitoylation of Desmoglein 2 Is a Regulator of Assembly Dynamics and Protein Turnover. [PDF]
, 2016 Desmosomes are prominent adhesive junctions present between many epithelial cells as well as cardiomyocytes. The mechanisms controlling desmosome assembly and remodeling in epithelial and cardiac tissue are poorly understood.
Johnson, Keith R. +7 more
core +2 more sources