Results 61 to 70 of about 18,739,280 (231)

Case report: Documentation of cutaneous only pemphigus vulgaris without history of mucosal lesions in North America

Frontiers in Immunology, 2022
BackgroundPemphigus is a group of autoimmune blistering diseases including Pemphigus vulgaris (PV) and Pemphigus foliaceus (PF). These conditions exhibit lesions with mucosal or mucocutaneous (PV) or cutaneous (PF) morphology, as framed by the Desmoglein
John Baker, Kristina Seiffert-Sinha, Animesh A. Sinha   +2 more
doaj   +1 more source

Suppression of the Immune Response Against Exogenous Desmoglein 3 in Desmoglein 3 Knockout Mice: An Implication for Gene Therapy [PDF]

Journal of Investigative Dermatology, 2003
Gene therapies for recessive genetic diseases may provoke unwanted immune responses against the introduced gene product because patients, especially those with null mutation of a certain protein, have no tolerance for the protein of interest. This study used desmoglein 3 knockout (Dsg3-/-) mice as a disease model for a genetic defect in DSG3, to ...
Ohyama, Manabu, Ota, Takayuki, Aoki, Miyo, Tsunoda, Kazuyuki, Harada, Reiko, Koyasu, Shigeo, Nishikawa, Takeji, Amagai, Masayuki   +7 more
openaire   +2 more sources

Prognostic Significance of Desmoglein 2 and Desmoglein 3 in Esophageal Squamous Cell Carcinoma

Asian Pacific Journal of Cancer Prevention, 2014
Desmogleins (DSGs) are major members among the desmosomal cadherins critically involved in cell-cell adhesion and the maintenance of normal tissue architecture in epithelia. Reports exploring links of DSG family member expression with cancers are few and vary.
Wang-Kai, Fang, Wei, Gu, Lian-Di, Liao, Bo, Chen, Zhi-Yong, Wu, Jian-Yi, Wu, Jian, Shen, Li-Yan, Xu, En-Min, Li   +8 more
openaire   +3 more sources

Is transition between subtypes of pemphigus possible? A series of pemphigus vulgaris patients showing the transition to pemphigus foliaceus

Anais Brasileiros de Dermatologia, 2023
Background Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are subtypes of pemphigus with distinct clinical and laboratory features. The transition between these two subtypes has rarely been reported previously.
Rifkiye Kucukoglu, Tugba Atci, Gizem Pinar Sun   +2 more
doaj   +1 more source

Transgenic kallikrein 14 mice display major hair shaft defects associated with desmoglein 3 and 4 degradation, abnormal epidermal differentiation and Il-36 signature.

Journal of Investigative Dermatology, 2020
Netherthon syndrome (NS) is a rare autosomal recessive skin disease caused by loss-of-function mutations in SPINK5 encoding Lymphoepithelial Kazal-Type-related Inhibitor (LEKTI) that results in unopposed activity of epidermal kallikrein-related ...
O. Gouin, C. Barbieux, F. Leturcq, Mathilde Bonnet des Claustres, E. Petrova, A. Hovnanian   +5 more
semanticscholar   +1 more source

A Subset of Pemphigus Foliaceus Patients Exhibits Pathogenic Autoantibodies Against Both Desmoglein-1 and Desmoglein-3 [PDF]

Journal of Investigative Dermatology, 2002
In pemphigus vulgaris the major pathogenic antibody binds desmoglein-3, and mediates mucosal disease. Development of cutaneous disease is associated with acquisition of antibodies to desmoglein-1. In pemphigus foliaceus, and its endemic form, fogo selvagem by contrast, the major pathogenic antibody recognizes desmoglein-1 and mediates cutaneous disease
Arteaga, Luis A., Prisayanh, Philip S., Warren, Simon J.P., Liu, Zhi, Diaz, Luis A., Lin, Mong-Shang   +5 more
openaire   +2 more sources

Involvement of Nail Apparatus in Pemphigus Vulgaris in Ethnic Poles Is Infrequent

Frontiers in Medicine, 2018
Pemphigus vulgaris lesions have a tendency to localize around natural body orifices. The aim here was to analyze the involvement of nail apparatus in pemphigus vulgaris.
Pawel Pietkiewicz, Pawel Pietkiewicz, Monika Bowszyc-Dmochowska, Justyna Gornowicz-Porowska, Marian Dmochowski   +4 more
doaj   +1 more source

Pemphigus Vulgaris IgG Directly Inhibit Desmoglein 3-Mediated Transinteraction [PDF]

The Journal of Immunology, 2008
Abstract The autoimmune blistering skin disease pemphigus is caused by autoantibodies against keratinocyte surface Ags. In pemphigus vulgaris (PV), autoantibodies are primarily directed against desmosomal cadherins desmoglein (Dsg) 3 and Dsg 1, whereas pemphigus foliaceus (PF) patients only have Abs against Dsg 1.
Wolfgang-Moritz, Heupel, Detlef, Zillikens, Detlev, Drenckhahn, Jens, Waschke   +3 more
openaire   +2 more sources

Proton pump inhibitors modulate esophageal epithelial barrier function and crosstalk with eosinophils. [PDF]

Pediatr Allergy Immunol
Abstract Background Eosinophilic esophagitis (EoE) is a chronic allergic disorder driven by type 2 inflammation, characterized by eosinophilic infiltration and esophageal epithelial abnormalities, including barrier dysfunction, basal cell hyperplasia, epithelial thickening, and loss of differentiation.
Gautam R, Lal M, Carroll MC, Mrozek Z, Trachsel T, Beers J, Ruffner MA.   +6 more
europepmc   +2 more sources

YAP Inhibition by Verteporfin Causes Downregulation of Desmosomal Genes and Proteins Leading to the Disintegration of Intercellular Junctions

Life, 2022
The Hippo-YAP pathway serves as a central signalling hub in epithelial tissue generation and homeostasis. Yes-associated protein (YAP) is an essential downstream transcription cofactor of this pathway, with its activity being negatively regulated by ...
Yunying Huang, Usama Sharif Ahmad, Ambreen Rehman, Jutamas Uttagomol, Hong Wan   +4 more
doaj   +1 more source