Results 21 to 30 of about 20,510 (243)

The Desmosome [PDF]

Cold Spring Harbor Perspectives in Biology, 2009
Desmosomes are intercellular junctions that tether intermediate filaments to the plasma membrane. Desmogleins and desmocollins, members of the cadherin superfamily, mediate adhesion at desmosomes. Cytoplasmic components of the desmosome associate with the desmosomal cadherin tails through a series of protein interactions, which serve to recruit ...
Emmanuella, Delva, Dana K, Tucker, Andrew P, Kowalczyk   +2 more
openaire   +2 more sources

Desmin variants: Trigger for cardiac arrhythmias?

Frontiers in Cell and Developmental Biology, 2022
Desmin (DES) is a classical type III intermediate filament protein encoded by the DES gene. Desmin is abundantly expressed in cardiac, skeletal, and smooth muscle cells.
Wei Su, Wei Su, Stan W. van Wijk, Stan W. van Wijk, Bianca J. J. M. Brundel, Bianca J. J. M. Brundel   +5 more
doaj   +1 more source

Pulmonary Neuroendocrine Neoplasms Overexpressing Epithelial-Mesenchymal Transition Mechanical Barriers Genes Lack Immune-Suppressive Response and Present an Increased Risk of Metastasis

Frontiers in Oncology, 2021
Typical carcinoids (TC), atypical carcinoids (AC), large cell neuroendocrine carcinomas (LCNEC), and small cell lung carcinomas (SCLC) encompass a bimodal spectrum of metastatic tumors with morphological, histological and histogenesis differences, The ...
Tabatha Gutierrez Prieto, Camila Machado Baldavira, Juliana Machado-Rugolo, Juliana Machado-Rugolo, Cecília Farhat, Eloisa Helena Ribeiro Olivieri, Vanessa Karen de Sá, Eduardo Caetano Abilio da Silva, Marcelo Luiz Balancin, Alexandre Muxfeldt Ab´Saber, Teresa Yae Takagaki, Vladmir Cláudio Cordeiro de Lima, Vladmir Cláudio Cordeiro de Lima, Vera Luiza Capelozzi   +13 more
doaj   +1 more source

Assembly of Desmosomal Cadherins into Desmosomes is Isoform Dependent [PDF]

Journal of Investigative Dermatology, 2001
Desmosomes are intercellular adhesive junctions that exhibit cell- and differentiation-specific differences in their molecular composition. In complex epithelia, desmosomes contain multiple representatives of the desmosomal cadherin family, which includes three desmogleins and three desmocollins.
Evangeline V. Amargo, Suzanne M. Norvell, Lauren T. Pascoe, Kathleen J. Green, Ken Ishii, Leslie J. Bannon   +5 more
openaire   +3 more sources

Mechanisms Causing Acantholysis in Pemphigus-Lessons from Human Skin

Frontiers in Immunology, 2022
Pemphigus vulgaris (PV) is an autoimmune bullous skin disease caused primarily by autoantibodies (PV-IgG) against the desmosomal adhesion proteins desmoglein (Dsg)1 and Dsg3.
Desalegn Tadesse Egu, Thomas Schmitt, Jens Waschke   +2 more
doaj   +1 more source

Milestones in Investigative Dermatology: The Desmosome [PDF]

Journal of Investigative Dermatology, 2007
Andrew P. Kowalczyk, David S. Rubenstein, David R. Garrod, Kathleen J. Green, John R. Stanley   +4 more
openalex   +5 more sources

SIRT1 activation and its effect on intercalated disc proteins as a way to reduce doxorubicin cardiotoxicity

Frontiers in Pharmacology, 2022
According to the World Health Organization, the neoplasm is one of the main reasons for morbidity and mortality worldwide. At the same time, application of cytostatic drugs like an independent type of cancer treatment and in combination with surgical ...
Ekaterina Podyacheva, Yana Toropova
doaj   +1 more source

Proteomic analysis of desmosomes reveals novel components required for epidermal integrity

Molecular Biology of the Cell, 2020
Desmosomes are cell–cell adhesions necessary for the maintenance of tissue integrity in the skin and heart. While the core components of desmosomes have been identified, peripheral components that modulate canonical or noncanonical desmosome functions ...
K. Badu-Nkansah, T. Lechler
semanticscholar   +1 more source

YAP Inhibition by Verteporfin Causes Downregulation of Desmosomal Genes and Proteins Leading to the Disintegration of Intercellular Junctions

Life, 2022
The Hippo-YAP pathway serves as a central signalling hub in epithelial tissue generation and homeostasis. Yes-associated protein (YAP) is an essential downstream transcription cofactor of this pathway, with its activity being negatively regulated by ...
Yunying Huang, Usama Sharif Ahmad, Ambreen Rehman, Jutamas Uttagomol, Hong Wan   +4 more
doaj   +1 more source

The Desmin Mutation DES-c.735G>C Causes Severe Restrictive Cardiomyopathy by Inducing In-Frame Skipping of Exon-3

Biomedicines, 2021
Currently, little is known about the genetic background of restrictive cardiomyopathy (RCM). Herein, we screened an index patient with RCM in combination with atrial fibrillation using a next generation sequencing (NGS) approach and identified the ...
Andreas Brodehl, Carsten Hain, Franziska Flottmann, Sandra Ratnavadivel, Anna Gaertner, Bärbel Klauke, Jörn Kalinowski, Hermann Körperich, Jan Gummert, Lech Paluszkiewicz, Marcus-André Deutsch, Hendrik Milting   +11 more
doaj   +1 more source