Results 21 to 30 of about 13,508 (185)

Dsg3 epitope-specific signalling in pemphigus

Frontiers in Immunology, 2023
IntroductionPemphigus is an autoantibody driven disease that impairs the barrier function of the skin and mucosa by disrupting desmosomes and thereby impeding cellular cohesion. It is known that the different clinical phenotypes of pemphigus vulgaris (PV)
Thomas Schmitt, Christoph Hudemann, Sina Moztarzadeh, Michael Hertl, Ritva Tikkanen, Jens Waschke   +5 more
doaj   +1 more source

Down-regulation of desmosomes in cultured cells: the roles of PKC, microtubules and lysosomal/proteasomal degradation.

PLoS ONE, 2014
Desmosomes are intercellular adhesive junctions of major importance for tissue integrity. To allow cell motility and migration they are down-regulated in epidermal wound healing.
Selina McHarg, Gemma Hopkins, Lusiana Lim, David Garrod   +3 more
doaj   +1 more source

New insights into desmosome regulation and pemphigus blistering as a desmosome-remodeling disease

Kaohsiung Journal of Medical Sciences, 2013
Desmosomes in keratinocytes are the most important intercellular adhering junctions that provide structural strength for the epidermis. These junctions are connected directly with desmosomal cadherin proteins.
Yasuo Kitajima
doaj   +1 more source

Expression and Significance of Cadherins and Its Subtypes in Development and Progression of Oral Cancers: A Review [PDF]

Journal of Clinical and Diagnostic Research, 2015
Cadherins are a family of transmembranous glycoproteins responsible for calcium-dependent intercellular adhesion. Absence or loss of function of E-cadherin leads to the disappearance of epithelial characteristics of the cells and generates higher ...
Yogesh Chand Rajwar, Nitul Jain, Gouri Bhatia, Neha Sikka, Balram Garg, Esha Walia   +5 more
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SIRT1 activation and its effect on intercalated disc proteins as a way to reduce doxorubicin cardiotoxicity

Frontiers in Pharmacology, 2022
According to the World Health Organization, the neoplasm is one of the main reasons for morbidity and mortality worldwide. At the same time, application of cytostatic drugs like an independent type of cancer treatment and in combination with surgical ...
Ekaterina Podyacheva, Yana Toropova
doaj   +1 more source

Pulmonary Neuroendocrine Neoplasms Overexpressing Epithelial-Mesenchymal Transition Mechanical Barriers Genes Lack Immune-Suppressive Response and Present an Increased Risk of Metastasis

Frontiers in Oncology, 2021
Typical carcinoids (TC), atypical carcinoids (AC), large cell neuroendocrine carcinomas (LCNEC), and small cell lung carcinomas (SCLC) encompass a bimodal spectrum of metastatic tumors with morphological, histological and histogenesis differences, The ...
Tabatha Gutierrez Prieto, Camila Machado Baldavira, Juliana Machado-Rugolo, Juliana Machado-Rugolo, Cecília Farhat, Eloisa Helena Ribeiro Olivieri, Vanessa Karen de Sá, Eduardo Caetano Abilio da Silva, Marcelo Luiz Balancin, Alexandre Muxfeldt Ab´Saber, Teresa Yae Takagaki, Vladmir Cláudio Cordeiro de Lima, Vladmir Cláudio Cordeiro de Lima, Vera Luiza Capelozzi   +13 more
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Desmosomes In Vivo

Dermatology Research and Practice, 2010
The structure, function, and regulation of desmosomal adhesion in vivo are discussed. Most desmosomes in tissues exhibit calcium-independent adhesion, which is strongly adhesive or “hyperadhesive”. This is fundamental to tissue strength.
David Garrod
doaj   +1 more source

Desmosomes in Developing Human Epidermis

Dermatology Research and Practice, 2010
Desmosomes play important roles in the cell differentiation and morphogenesis of tissues. Studies on animal models have greatly increased our knowledge on epidermal development while reports on human developing skin are rare due to the difficult ...
Sirkku Peltonen, Laura Raiko, Juha Peltonen   +2 more
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Desmosomes as Signaling Hubs in the Regulation of Cell Behavior

Frontiers in Cell and Developmental Biology, 2021
Desmosomes are intercellular junctions, which preserve tissue integrity during homeostatic and stress conditions. These functions rely on their unique structural properties, which enable them to respond to context-dependent signals and transmit them to ...
Lisa Müller, Mechthild Hatzfeld, René Keil   +2 more
doaj   +1 more source

YAP Inhibition by Verteporfin Causes Downregulation of Desmosomal Genes and Proteins Leading to the Disintegration of Intercellular Junctions

Life, 2022
The Hippo-YAP pathway serves as a central signalling hub in epithelial tissue generation and homeostasis. Yes-associated protein (YAP) is an essential downstream transcription cofactor of this pathway, with its activity being negatively regulated by ...
Yunying Huang, Usama Sharif Ahmad, Ambreen Rehman, Jutamas Uttagomol, Hong Wan   +4 more
doaj   +1 more source