Results 21 to 30 of about 12,732 (174)
Life, 2022 The Hippo-YAP pathway serves as a central signalling hub in epithelial tissue generation and homeostasis. Yes-associated protein (YAP) is an essential downstream transcription cofactor of this pathway, with its activity being negatively regulated by ...
Yunying Huang +4 more
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Cells, 2018 Cell-cell junctions are critical structures in a number of tissues for mechanically coupling cells together, cell-to-cell signaling, and establishing a barrier. In many tissues, desmosomes are an important component of cell-cell junctions.
Sindora R. Baddam +9 more
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Desmin variants: Trigger for cardiac arrhythmias?
Frontiers in Cell and Developmental Biology, 2022 Desmin (DES) is a classical type III intermediate filament protein encoded by the DES gene. Desmin is abundantly expressed in cardiac, skeletal, and smooth muscle cells.
Wei Su +5 more
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PLoS ONE, 2014 Desmosomes are intercellular adhesive junctions of major importance for tissue integrity. To allow cell motility and migration they are down-regulated in epidermal wound healing.
Selina McHarg +3 more
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New insights into desmosome regulation and pemphigus blistering as a desmosome-remodeling disease
Kaohsiung Journal of Medical Sciences, 2013 Desmosomes in keratinocytes are the most important intercellular adhering junctions that provide structural strength for the epidermis. These junctions are connected directly with desmosomal cadherin proteins.
Yasuo Kitajima
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Mechanisms Causing Acantholysis in Pemphigus-Lessons from Human Skin
Frontiers in Immunology, 2022 Pemphigus vulgaris (PV) is an autoimmune bullous skin disease caused primarily by autoantibodies (PV-IgG) against the desmosomal adhesion proteins desmoglein (Dsg)1 and Dsg3.
Desalegn Tadesse Egu +2 more
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Biomedicines, 2021 Currently, little is known about the genetic background of restrictive cardiomyopathy (RCM). Herein, we screened an index patient with RCM in combination with atrial fibrillation using a next generation sequencing (NGS) approach and identified the ...
Andreas Brodehl +11 more
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Desmosomes in Developing Human Epidermis
Dermatology Research and Practice, 2010 Desmosomes play important roles in the cell differentiation and morphogenesis of tissues. Studies on animal models have greatly increased our knowledge on epidermal development while reports on human developing skin are rare due to the difficult ...
Sirkku Peltonen +2 more
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Desmosomal Junctions and Connexin-43 Remodeling in High-Pacing-Induced Heart Failure Dogs
Anatolian Journal of Cardiology, 2023 Background: While desmosomal junctions and gap junction remodeling are among the arrhythmogenic substrates, the fate of desmosomal and gap junctions in high-pacing-induced heart failure remains unclear. This aim of this study was to determine the fate of
Qing Wang +6 more
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Paradoxical Roles of Desmosomal Components in Head and Neck Cancer
Biomolecules, 2021 Desmosomes are intercellular adhesion complexes involved in various aspects of epithelial pathophysiology, including tissue homeostasis, morphogenesis, and disease development.
Yin-Qiao Liu +3 more
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