Deubiquitinating Enzymes in Parkinson’s Disease [PDF]
Frontiers in Physiology, 2020 Mitochondrial dysfunction and neurodegeneration have been directly correlated in many neurodegenerative disorders. Parkinson’s disease (PD) in particular has been extensively studied in this context because of its well-characterized association with ...
Joy Chakraborty, Elena Ziviani
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Accelerating inhibitor discovery for deubiquitinating enzymes [PDF]
Nature Communications, 2023 Deubiquitinases (DUBs) are key signaling enzymes, many of which lack selective inhibitors. Chan et al. pair a DUB-focused covalent library to mass spectrometry activity-based protein profiling, leading to selective hits against 23 endogenous DUBs and a ...
Wai Cheung Chan +19 more
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Modified activities of macrophages’ deubiquitinating enzymes after Francisella infection [PDF]
Frontiers in Immunology, 2023 Francisella tularensis influences several host molecular/signaling pathways during infection. Ubiquitination and deubiquitination are among the most important regulatory mechanisms and respectively occur through attachment or removal of the ubiquitin ...
Vera Vozandychova +8 more
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Neutron-encoded diubiquitins to profile linkage selectivity of deubiquitinating enzymes [PDF]
Nature Communications, 2023 Most insights into deubiquitinase (DUB) substrate specificity originate from studies with isolated di-ubiquitins (diUb), but in cells diUbs with different linkage types coexist.
Bianca D. M. van Tol +13 more
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Structural and Functional Basis of JAMM Deubiquitinating Enzymes in Disease [PDF]
Biomolecules, 2022 Deubiquitinating enzymes (DUBs) are a group of proteases that are important for maintaining cell homeostasis by regulating the balance between ubiquitination and deubiquitination.
Xin Pan +5 more
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Research progress of deubiquitinating enzymes in cerebral ischemia-reperfusion injury [PDF]
Frontiers in Aging NeuroscienceCerebral ischemia-reperfusion injury (CIRI) is a critical pathological process driving neurological deterioration following ischemic stroke, involving multifaceted mechanisms such as inflammatory cascades, oxidative stress, and programmed cell death (PCD)
XiaoHong Qin +6 more
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Post-Translational Modifications of Deubiquitinating Enzymes: Expanding the Ubiquitin Code [PDF]
Frontiers in Pharmacology, 2021 Post-translational modifications such as ubiquitination play important regulatory roles in several biological processes in eukaryotes. This process could be reversed by deubiquitinating enzymes (DUBs), which remove conjugated ubiquitin molecules from ...
Yanfeng Wang, Feng Wang
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Deubiquitinating enzymes in parkinson’s disease: molecular mechanisms and therapeutic potential [PDF]
Molecular MedicineParkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the pathological accumulation of α-synuclein aggregates and the selective degeneration of dopaminergic neurons in the substantia nigra.
Yarong Wu +11 more
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The Potential Role of Deubiquitinating Enzymes (DUBs) in Male Fertility [PDF]
BiomoleculesUbiquitination dynamically regulates critical cellular processes, including cell cycle progression, apoptosis, DNA repair, and chromatin remodeling. Deubiquitinating enzymes (DUBs) negatively regulate protein ubiquitination and are equally important for ...
Jung Min Kim
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The Functional Deubiquitinating Enzymes in Control of Innate Antiviral Immunity [PDF]
Advanced Science, 2021 Innate antiviral immunity is the first line of host defense against invading viral pathogens. Immunity activation primarily relies on the recognition of pathogen‐associated molecular patterns (PAMPs) by pattern recognition receptors (PRRs).
Zhi Zong +4 more
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