An efficient synthesis of the guaiane sesquiterpene (−)-isoguaiene by domino metathesis
Beilstein Journal of Organic Chemistry, 2019 (−)-Isoguaiene was prepared from (S)-citronellal in only 9–10 steps with good overall yields. Either a trienyne or a dienediyne metathesis and highly diastereoselective organocatalytic Michael additions of aldehydes derived from (S)-citronellal served as
Yuzhou Wang +3 more
doaj +1 more source
Chemical Science, 2016 The diastereoselective coupling of O-substituted arylhydroxamates and cyclopropenes mediated by Rh(iii) catalysis was successfully developed.
Natthawat Semakul +3 more
semanticscholar +1 more source
Alkynyltriazenes in Photochemical Metal‐Free Doyle–Kirmse Rearrangements
Angewandte Chemie International Edition, EarlyView.A metal‐ and additive‐free photocatalytic Doyle–Kirmse reaction of alkynyl triazenes is described, proceeding via cyanocarbene intermediates. This strategy enables the efficient construction of highly substituted asymmetric carbon centers with broad substrate scope, delivering synthetically valuable nitriles.
Ningning Liu +7 more
wiley +1 more source
Synthetic Studies Directed Toward Streptenol D: Enantioselective Preparation of the 3,5-diacetoxy-6\u3cem\u3eE\u3c/em\u3e,8\u3cem\u3eE\u3c/em\u3e-decadiene Segment [PDF]
, 1998 The enantioselective preparation of 2-(3′R,5′R-diacetoxy-6E,8E-decadienyl)-1,3-dioxane, (+)-13, is described. This synthesis of the skeleton of streptenol D utilizes the ability of a diene-complexed (tricarbonyl)iron unit to serve as a protecting and ...
Dasgupta, Bireshwar, Donaldson, William
core +1 more source
Network-analysis-guided synthesis of weisaconitine D and liljestrandinine. [PDF]
, 2015 General strategies for the chemical synthesis of organic compounds, especially of architecturally complex natural products, are not easily identified. Here we present a method to establish a strategy for such syntheses, which uses network analysis.
Gallego, GM +8 more
core +2 more sources
Stereochemical assignment of the protein-protein interaction inhibitor JBIR-22 by total synthesis [PDF]
, 2015 The authors acknowledge the EPSRC and Cancer Research UK (CRUK Grant No. C21383/A6950) for funding this research.Recent reports have highlighted the biological activity associated with a sub-family of the tetramic acid class of natural products.
Healy, Alan +4 more
core +1 more source
Synthesis and study of biological activity of tetrahydro-1H-[3]-benzazepines [PDF]
, 2017 The 3-Benzazepines are an important class of compounds in drug discovery due to their biological activity such as analgesic, antihypertensive or anticancer properties as well as dopaminergic or antidopaminergic activity. In particular, the tetrahydro-1H-[
Díaz, Amelia +4 more
core
Diastereoselective three-component synthesis of beta-amino carbonyl compounds using diazo compounds, boranes, and acyl imines under catalyst-free conditions [PDF]
, 2014 Diazo compounds, boranes, and acyl imines undergo a three-component Mannich condensation reaction under catalyst-free conditions to give the anti β-amino carbonyl compounds in high diastereoselectivity.
Luan, Yi +4 more
core +1 more source
Intermolecular Enantioselective Nickel‐Catalyzed Arylation of Un‐Activated C(sp3)─H Bond
Angewandte Chemie International Edition, EarlyView.Ni: a new solution for asymmetric C(sp3)─H activation. The stereoselective synthesis of all‐carbon quaternary stereogenic centres is achieved via enantioselective C(sp3)─H arylation using a Ni‐BINOL‐derived catalyst. Rational catalytic cycle design uncovers a new reaction pathway that can efficiently induce chiral information during the stereoselective
Erwan Brunard +4 more
wiley +1 more source
Chemistry and Biology of Streptogramin A Antibiotics [PDF]
, 2007 The streptogramin A antibiotics have proven to be highly active against Gram positive bacteria, particularly methicillin-resistant Staphylococcus aureus. Members of this group of compounds are characterized by a 23-membered macrocycles containing polyene,
Ahmed, Fahim, Donaldson, William
core +1 more source