Results 21 to 30 of about 38,088 (249)
Cells, 2021 The social amoeba Dictyostelium discoideum provides an excellent model for research across a broad range of disciplines within biology. The organism diverged from the plant, yeast, fungi and animal kingdoms around 1 billion years ago but retains common ...
Robin S. B. Williams +6 more
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The past, present and future of Dictyostelium as a model system.
International Journal of Developmental Biology, 2019 The social amoeba Dictyostelium discoideum has been a preferred model organism during the last 50 years, particularly for the study of cell motility and chemotaxis, phagocytosis and macropinocytosis, intercellular adhesion, pattern formation, caspase ...
S. Bozzaro
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Visualization of c-di-GMP in multicellular Dictyostelium stages
Frontiers in Cell and Developmental Biology, 2023 The bacterial signaling molecule cyclic diguanosine monophosphate (c-di-GMP) is only synthesized and utilized by the cellular slime mold Dictyostelium discoideum among eukaryotes.
Hayato Ide +3 more
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Oscillatory cAMP cell-cell signalling persists during multicellular Dictyostelium development
Communications Biology, 2019 Propagating waves of cAMP, periodically initiated in the aggregation centre, are known to guide the chemotactic aggregation of hundreds of thousands of starving individual Dictyostelium discoideum cells into multicellular aggregates.
Gail A. Singer, T. Araki, C. Weijer
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PLoS ONE, 2018 Dictyostelium has a mature technology for molecular-genetic manipulation based around transfection using several different selectable markers, marker re-cycling, homologous recombination and insertional mutagenesis, all supported by a well-annotated ...
Peggy I. Paschke +9 more
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MAPKs in development: insights from Dictyostelium signaling pathways
Biomolecular Concepts, 2011 Mitogen activated protein kinases (MAPKs) play important roles in the development of eukaryotic organisms through the regulation of signal transduction pathways stimulated by external signals.
Hadwiger Jeffrey A., Nguyen Hoai-Nghia
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Acanthamoeba and Dictyostelium as Cellular Models for Legionella Infection
Frontiers in Cellular and Infection Microbiology, 2018 Environmental bacteria of the genus Legionella naturally parasitize free-living amoebae. Upon inhalation of bacteria-laden aerosols, the opportunistic pathogens grow intracellularly in alveolar macrophages and can cause a life-threatening pneumonia ...
A. L. Swart +4 more
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Lysosomes appear as the auto-fluorescent vacuoles in Dictyostelium discoideum cells
Pteridines, 2016 Dictyostelium discoideum cells contain auto-fluorescent vacuoles. To determine the identity of these vacuoles, the fluorescent dye 4-nitro-7-(1-piperazinyl)-2,1,3-benzoxadiazole (NBD-PZ) was used to stain the lysosomes in D. discoideum cells. Neither the
Kainuma Hiroki +4 more
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Disease Models & Mechanisms, 2018 Valproic acid (VPA) provides a common treatment for both epilepsy and bipolar disorder; however, common cellular mechanisms relating to both disorders have yet to be proposed.
Lin Song +10 more
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CRISPR/Cas9 mediated targeting of multiple genes in Dictyostelium
Scientific Reports, 2018 CRISPR/Cas9 has emerged in various organisms as a powerful technology for targeted gene knockout; however, no reports of editing the Dictyostelium genome efficiently using this system are available.
R. Sekine, T. Kawata, Tetsuya Muramoto
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