Results 101 to 110 of about 4,838,550 (240)

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

The marginal efficiency of utilization of all ileal digestible indispensable amino acids for protein gain is lower than 30% in preruminant calves between 80 and 240 kg live weight

, 1998
A previous study showed that the marginal efficiency of utilization of digestible nitrogen for deposition in the body in preruminant calves is only ~30%. The study consisted of two similar experiments that were performed in two live weight ranges: 80-160
Gerrits, W.J.J., Schrama, J.W., Tamminga, S.   +2 more
core  

)

, 2020
Chickpea is a widely produced pulse crop, but requires processing prior to human consumption. Protein bioavailability and amino acid quantity of chickpea flour can be altered by multiple factors including processing method.
Jason Neufeld, Appah, Paulyn, Alphonsus Utioh, Neufeld, Jason, House, James, Franczyk, Adam J, Matthew G. Nosworthy, Peter Frohlich, Adam J. Franczyk, Utioh, Alphonsus, Gerardo Medina, Medina, Gerardo, James D. House, Nosworthy, Matthew G, Bunyamin Tar'an, Tar'an, Bunyamin, Paulyn Appah, Frohlich, Peter   +17 more
core   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

In vitro protein digestibility to replace in vivo digestibility for purposes of nutrient content claim substantiation in North America's context

Frontiers in Nutrition
The reliance by North American regulatory authorities on in vivo rodent bioassays—Protein Correct-Amino Acid Score (PDCAAS) in the U.S. and Protein Efficiency Ratio (PER) in Canada—to measure the protein quality for protein content claim substantiation ...
Elaine S. Krul, Amanda G. A. Sá, Amanda G. A. Sá, Erin M. Goldberg, Erin M. Goldberg, James D. House, James D. House   +6 more
doaj   +1 more source

Comparison of different protein evaluation systems for growing pigs: Digestible crude protein, and total, faecal digestible and ileal digestible amino acid intakes as performance response predictors [PDF]

, 1994
The validity of apparent faecal digestible crude protein and total, apparent faecal or ileal digestible amino acid intakes (lysine, threonine and methionine) as animal performance predictors was evaluated on the basis of digestibility coefficients ...
Jarmo Valaja
core  

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Effects and Mechanisms of Cooking and Milling on Protein Nutrition in Whole Grain Highland Barley Foods

Shipin gongye ke-ji
In order to explore the mechanism of processing methods affecting protein nutrition in whole grain foods, cooked whole-grain highland barley products (rice) and flour-based products (noodles) were selected as the research objects, with raw highland ...
Wanyu XUE, Lulu FU, Bo LI
doaj   +1 more source