Results 1 to 10 of about 5,247 (209)

Four New Pairs of MetO-Containing Diketopiperazine Enantiomers: Isolation, Synthesis and Potential Anti-Parkinson’s Disease Activity [PDF]

Marine Drugs
Four new methionine sulfoxide-containing diketopiperazines, (+)-dysidmetsulfoxide A [(+)-1], (+)-dysidmetsulfoxide B [(+)-2], (+)-dysidmetsulfoxide C [(+)-3] and (−)-dysidmetsulfoxide C [(−)-3], were isolated from the South China Sea sponge Dysidea sp ...
Yu Lei, Zhenyu Yang, Daichun Li, Xiaojian Liao, Chamari Hettiarachchi, Bingxin Zhao, Shihai Xu   +6 more
doaj   +2 more sources

Molecular networking derived from untargeted LC-MS/MS analysis to discover inhibitors of RANKL-induced osteoclastogenesis from Egyptian marine sponge-associated fungi [PDF]

Scientific Reports
In continuous search for RANKL induced osteoclastogenesis inhibitors, twenty-six fungal isolates were obtained from ten Red Sea marine sponges collected from Egypt and the ethyl acetate fractions of their cultures’ methanol extracts were assessed in ...
Abdelhalim A. Elgahamy, Ahmed H. El-Desoky, Asmaa M. Otify, Ahlam M. El Fishawy, Ahmed A. El-Beih   +4 more
doaj   +2 more sources

Novel 2,5-Diketopiperazines with In Vitro Activities against Protozoan Parasites of Tropical Diseases [PDF]

Pharmaceuticals
Malaria, Chagas disease, and leishmaniasis are tropical diseases caused by protozoan parasites of the genera Plasmodium, Trypanosoma and Leishmania, respectively.
Isabela P. Ceravolo, Letícia F. Leoni, Antoniana U. Krettli, Silvane M. F. Murta, Daniela de M. Resende, Mariza G. F. de M. L. Cruz, Jodieh O. S. Varejão, Lorena L. Mendes, Eduardo V. V. Varejão, Markus Kohlhoff   +9 more
doaj   +2 more sources

Restraining Staphylococcus aureus Virulence Factors and Quorum Sensing through Lactic Acid Bacteria Supernatant Extracts [PDF]

Antibiotics
The escalating prevalence of antibiotic-resistant bacteria poses a grave threat to human health, necessitating the exploration of novel alternatives to conventional antibiotics.
Myriam Anabel Díaz, Esteban Gabriel Vega-Hissi, María Amparo Blázquez, María Rosa Alberto, Mario Eduardo Arena   +4 more
doaj   +2 more sources

Exploring the Diverse Landscape of Fungal Cytochrome P450‐Catalyzed Regio‐ and Stereoselective Dimerization of Diketopiperazines [PDF]

Advanced Science
Dimeric indole‐containing diketopiperazines (di‐DKPs) are a diverse group of natural products produced through cytochrome P450‐catalyzed C–C or C–N coupling reactions.
Chuanteng Ma, Wenxue Wang, Kaijin Zhang, Falei Zhang, Yimin Chang, Chunxiao Sun, Qian Che, Tianjiao Zhu, Guojian Zhang, Dehai Li   +9 more
doaj   +2 more sources

Characterisation of Cooked Cheese Flavour: Non-Volatile Components

Foods, 2023
This work examined the role of selected non-volatile compounds in cooked cheese flavour, both as tastants and as precursors of aroma generation in the Maillard reaction.
Rosa C. Sullivan, Samantha Nottage, Fiyinfolu Makinwa, Maria Jose Oruna-Concha, Colette C. Fagan, Jane K. Parker   +5 more
doaj   +1 more source

Structures and Biological Activities of Diketopiperazines from Marine Organisms: A Review

Marine Drugs, 2021
Diketopiperazines are potential structures with extensive biological functions, which have attracted much attention of natural product researchers for a long time.
Zhiqiang Song, Yage Hou, Qingrong Yang, Xinpeng Li, Shaohua Wu   +4 more
doaj   +1 more source

Use of molecular networking to identify 2,5-diketopiperazines in chocolates as potential markers of bean variety

Heliyon, 2022
2,5-diketopiperazines are cyclic dipeptides found, among others, in chocolate. Although those compounds are contributing greatly to its pleasant bitterness, they can also be seen as interesting markers of cocoa beans processing. To evaluate the influence
Amandine André, Bettina Casty, Lisa Ullrich, Irene Chetschik   +3 more
doaj   +1 more source

Bioactive Polyketide and Diketopiperazine Derivatives from the Mangrove-Sediment-Derived Fungus Aspergillus sp. SCSIO41407

Molecules, 2021
Ten polyketide derivatives (1–10), including a new natural product named (E)-2,4-dihydroxy-3-methyl-6-(2-oxopent-3-en-1-yl) benzaldehyde (1), and five known diketopiperazines (11–15), were isolated from the mangrove-sediment-derived fungus Aspergillus sp.
Jian Cai, Chunmei Chen, Yanhui Tan, Weihao Chen, Xiaowei Luo, Lianxiang Luo, Bin Yang, Yonghong Liu, Xuefeng Zhou   +8 more
doaj   +1 more source

Cyclodipeptides: From Their Green Synthesis to Anti-Age Activity

Biomedicines, 2022
Cyclodipeptides (CDPs) or diketopiperazines (DKPs) are often found in nature and in foodstuff and beverages and have attracted great interest for their bioactivities, biocompatibility, and biodegradability.
Veronica Mosetti, Beatrice Rosetti, Giovanni Pierri, Ottavia Bellotto, Simone Adorinni, Antonella Bandiera, Gianpiero Adami, Consiglia Tedesco, Matteo Crosera, Greta Camilla Magnano, Silvia Marchesan   +10 more
doaj   +1 more source