Results 11 to 20 of about 5,247 (209)

A facile synthesis of cysteine-based diketopiperazine from thiol-protected precursor [PDF]

Royal Society Open Science, 2018
l-Cysteine is one of the most promising biomass-based building blocks with great potential applications. Herein, we report a versatile synthetic route to produce cysteine-based 2,5-diketopiperazine (DKP) with good yield from the thiol-ene click reaction ...
Di Zhang, Wayne Wang
doaj   +1 more source

Chemical and Biological Studies of Endophytes Isolated from Marchantia polymorpha

Molecules, 2023
Natural bioresources, predominantly plants, have always been regarded as the richest source of drugs for diseases threatening humanity. Additionally, microorganism-originating metabolites have been extensively explored as weapons against bacterial ...
Mateusz Stelmasiewicz, Łukasz Świątek, Agnieszka Ludwiczuk   +2 more
doaj   +1 more source

Unambiguous Stereochemical Assignment of Cyclo(Phe-Pro), Cyclo(Leu-Pro), and Cyclo(Val-Pro) by Electronic Circular Dichroic Spectroscopy

Molecules, 2021
2,5-diketopiperazines (DKPs) are cyclic dipeptides ubiquitously found in nature. In particular, cyclo(Phe-Pro), cyclo(Leu-Pro), and cyclo(Val-Pro) are frequently detected in many microbial cultures.
Alison Domzalski, Liliana Margent, Valeria Vigo, Faizunnahar Dewan, Naga Vara Kishore Pilarsetty, Yujia Xu, Akira Kawamura   +6 more
doaj   +1 more source

Molecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric diketopiperazines

Nature Communications, 2020
Bacterial heterodimeric tryptophan-containing diketopiperazines (HTDKPs) are bioactive natural products that are difficult to access chemically. Here, the authors identify a family of three related HTDKP-forming cytochrome P450s and engineer key amino ...
Chenghai Sun, Zhenyao Luo, Wenlu Zhang, Wenya Tian, Haidong Peng, Zhi Lin, Zixin Deng, Bostjan Kobe, Xinying Jia, Xudong Qu   +9 more
doaj   +1 more source

Diketopiperazine Gels: New Horizons from the Self-Assembly of Cyclic Dipeptides

Molecules, 2021
Cyclodipeptides (CDPs) or 2,5-diketopiperazines (DKPs) can exert a variety of biological activities and display pronounced resistance against enzymatic hydrolysis as well as a propensity towards self-assembly into gels, relative to the linear-dipeptide ...
Marco Scarel, Silvia Marchesan
doaj   +1 more source

A Simple Defined Medium for the Production of True Diketopiperazines in Xylella fastidiosa and Their Identification by Ultra-Fast Liquid Chromatography-Electrospray Ionization Ion Trap Mass Spectrometry

Molecules, 2017
Diketopiperazines can be generated by non-enzymatic cyclization of linear dipeptides at extreme temperature or pH, and the complex medium used to culture bacteria and fungi including phytone peptone and trypticase peptone, can also produce cyclic ...
Michelli Massaroli da Silva, Moacir dos Santos Andrade, Anelize Bauermeister, Marcus Vinícius Merfa, Moacir Rossi Forim, João Batista Fernandes, Paulo Cezar Vieira, Maria Fátima das Graças Fernandes da Silva, Norberto Peporine Lopes, Marcos Antônio Machado, Alessandra Alves de Souza   +10 more
doaj   +1 more source

Cyclic Dipeptides: The Biological and Structural Landscape with Special Focus on the Anti-Cancer Proline-Based Scaffold

Biomolecules, 2021
Cyclic dipeptides, also know as diketopiperazines (DKP), the simplest cyclic forms of peptides widespread in nature, are unsurpassed in their structural and bio-functional diversity. DKPs, especially those containing proline, due to their unique features
Joanna Bojarska, Adam Mieczkowski, Zyta M. Ziora, Mariusz Skwarczynski, Istvan Toth, Ahmed O. Shalash, Keykavous Parang, Shaima A. El-Mowafi, Eman H. M. Mohammed, Sherif Elnagdy, Maha AlKhazindar, Wojciech M. Wolf   +11 more
doaj   +1 more source

Discovery of new diketopiperazines inhibiting Burkholderia cenocepacia quorum sensing in vitro and in vivo [PDF]

, 2016
Burkholderia cenocepacia, an opportunistic respiratory pathogen particularly relevant for cystic fibrosis patients, is difficult to eradicate due to its high level of resistance to most clinically relevant antimicrobials.
Azzalin, Alberto, Brackman, Gilles, Buroni, Silvia, Chiarelli, Laurent R, Coenye, Tom, Forneris, Federico, Israyilova, Aygun, Makarov, Vadim, Riabova, Olga, Riccardi, Giovanna, Savina, Sventlana, Scoffone, Viola C   +11 more
core   +2 more sources

Probing Anti-Leukemic Metabolites from Marine-Derived Streptomyces sp. LY1209

Metabolites, 2022
The unmet need for specific anti-leukemic agents for the treatment of acute lymphoblastic leukemia led us to screen a variety of marine-derived bacteria. The fermentation broth extract of Streptomyces sp.
You-Ying Chen, Lo-Yun Chen, Po-Jen Chen, Mohamed El-Shazly, Bo-Rong Peng, Yu-Cheng Chen, Chun-Han Su, Jui-Hsin Su, Ping-Jyun Sung, Pei-Tzu Yen, Lung-Shuo Wang, Kuei-Hung Lai   +11 more
doaj   +1 more source

Natural product diversity of actinobacteria in the Atacama Desert [PDF]

, 2018
Natural Product diversityPeer reviewedPublisher ...
Ebel, Rainer, Jaspars, Marcel, Rateb, Mostafa E.   +2 more
core   +3 more sources