Results 21 to 30 of about 5,247 (209)
Marine Drugs, 2022 Three new tripeptide derivatives asterripeptides A–C (1–3) were isolated from Vietnamese mangrove-derived fungus Aspergillus terreus LM.5.2. Structures of isolated compounds were determined by a combination of NMR and ESIMS techniques.
Elena V. Girich +9 more
doaj +1 more source
Design, Synthesis and Evaluation of 2,5-Diketopiperazines as Inhibitors of the MDM2-p53 Interaction. [PDF]
PLoS ONE, 2015 The transcription factor p53 is the main tumour suppressor in cells and many cancer types have p53 mutations resulting in a loss of its function. In tumours that retain wild-type p53 function, p53 activity is down-regulated by MDM2 (human murine double ...
Mariell Pettersson +8 more
doaj +1 more source
Molecules, 2022 An efficient method for the synthesis of functionalized peptidomimetics via multicomponent Ugi reaction has been developed. The application of trifluoroethanol (TFE) as a reaction medium provided desired products with good yields.
Parul Sahrawat +6 more
doaj +1 more source
Antibacterial modified diketopiperazines from two ascidians of the genus Didemnum [PDF]
, 2009 The chemical investigation of the crude extract of an ascidian of the genus Didemnumled to the isolation of the modified diketopiperazine rodriguesines A (1) and (2) as a mixture of homologues, which could be identified by analysis of spectroscopic data ...
BERLINCK, Roberto G. S. +9 more
core +1 more source
Concise Total Synthesis of (+)-Asperazine, (+)-Pestalazine A, and (+)-iso-Pestalazine A. Structure Revision of (+)-Pestalazine A [PDF]
, 2015 The concise, enantioselective total syntheses of (+)-asperazine (1), (+)-iso-pestalazine A (2), and (+)-pestalazine A (3) have been achieved by the development of a late-stage C3–C8′ Friedel–Crafts union of polycyclic diketopiperazines.
Fenton, Owen Shea +2 more
core +2 more sources
Molecules, 2012 The well-known Ugi reaction of aldehydes with amines, carboxylic acids and isocyanides leads to the formation of acyclic α-acylaminocarboxamides. Replacement of the carboxylic acid derivatives with β-acyl substituted acrylic acids gives
Ulrike Holzgrabe +4 more
doaj +1 more source
Marine Drugs, 2023 The fungal strain BC17 was isolated from sediments collected in the intertidal zone of the inner Bay of Cadiz and characterized as Emericellopsis maritima.
Jorge R. Virués-Segovia +10 more
doaj +1 more source
Concise total synthesis of (+)-bionectins A and C [PDF]
, 2013 The concise and efficient total synthesis of (+)-bionectins A and C is described. Our approach to these natural products features a new and scalable method for erythro-β-hydroxytryptophan amino acid synthesis, an intramolecular Friedel–Crafts reaction of
Adams, Timothy C. +3 more
core +1 more source
New Metabolites from the Marine Sponge Scopalina hapalia Collected in Mayotte Lagoon
Marine Drugs, 2022 The biological screening of 44 marine sponge extracts for the research of bioactive molecules, with potential application in the treatment of age-related diseases (cancer and Alzheimer’s disease) and skin aging, resulted in the selection of Scopalina ...
Charifat Saïd Hassane +13 more
doaj +1 more source
Bioactivity Profiles of Progressively Ring-Fluorinated Cyclohexyl Motifs in the WKYMVm Peptide as Formylpeptide FPR2 Agonists and in Keto-Piperazines as Antitrypanosome Agents. [PDF]
ChembiochemAll‐cis‐fluorinated cyclohexyl motifs with progressively increasing levels of fluorine are introduced into the WKYMVm peptide and a class of keto‐piperazine derivatives and assayed against the FPR2 receptor or the parasite Trypanosoma brucei, respectively.
He M +6 more
europepmc +2 more sources