Results 31 to 40 of about 1,001 (132)

Weighted Gene Co-expression Network Analysis of the Dioscin Rich Medicinal Plant Dioscorea nipponica

Frontiers in Plant Science, 2017
Dioscorea contains critically important species which can be used as staple foods or sources of bioactive substances, including Dioscorea nipponica, which has been used to develop highly successful drugs to treat cardiovascular disease.
Wei Sun, Wei Sun, Bo Wang, Bo Wang, Jun Yang, Weihao Wang, An Liu, Liang Leng, Li Xiang, Chi Song, Shilin Chen   +10 more
doaj   +1 more source

Comparative Transcriptome Analysis Identifies Putative Genes Involved in Dioscin Biosynthesis in Dioscorea zingiberensis

Molecules, 2018
Dioscorea zingiberensis is a perennial herb native to China. The rhizome of D. zingiberensis has long been used as a traditional Chinese medicine to treat rheumatic arthritis.
Jia Li, Qin Liang, Changfu Li, Mengdi Liu, Yansheng Zhang   +4 more
doaj   +1 more source

LIN28A blocks the EndMT process of high glucose‐induced HRMECs by stabilizing SIRT6 mRNA

Journal of Diabetes Investigation, EarlyView.
LIN28A promotes mRNA stability of SIRT6 to activate the AMPK signaling, thereby inhibiting the EndMT process induced by HG in HRMECs. ABSTRACT Background Diabetic retinopathy (DR) is a microvascular condition resulting from microangiopathy, causing gradual retinal damage and potential blindness.
Xueying Wang, Zixu Huang, Xiaohui Kuang, Yali Nan, Zhiwen Zhang, Zongming Song   +5 more
wiley   +1 more source

The Effects of Diosgenin on Hypolipidemia and Its Underlying Mechanism: A Review

Diabetes, Metabolic Syndrome and Obesity, 2021
Fengcui Sun,1 Xiufen Yang,1 Chaoqun Ma,1 Shizhao Zhang,1 Lu Yu,2 Haifei Lu,3 Guoliang Yin,1 Pengpeng Liang,1 Yanan Feng,1 Fengxia Zhang4 1Shandong University of Traditional Chinese Medicine, Jinan, 250000, People’s Republic of China; 2Tianjin University ...
Sun F, Yang X, Ma C, Zhang S, Yu L, Lu H, Yin G, Liang P, Feng Y, Zhang F   +9 more
doaj  

Rewiring Steroidal Metabolic Pathways for Diosgenin Production in Solanum nigrum

Plant Biotechnology Journal, EarlyView.
ABSTRACT Diosgenin is a key starting material for the synthesis of steroidal drugs, such as corticosteroids and sex hormones. While the primary commercial source of diosgenin is the tubers of Dioscorea spp., identifying alternative plant hosts capable of diosgenin biosynthesis could enhance its production.
Jongbu Lim, Keunhwa Kim, Jung Heo, Seung Mo Seo, Sungjun Choung, Hyeonjin Kim, Yuri Choi, Kyungsun Park, Hyejung Yun, Dongha Kim, Eun Song Lee, Junwoo Lee, Smita Mirsyad Warsadiharja, Saet Buyl Lee, Sunkyu Han, Soon Ju Park, Sang‐Gyu Kim   +16 more
wiley   +1 more source

Antimicrobial Effect of Spices and Their Phytochemicals: A Novel Approach to Overcoming Antibiotic Resistance

MedComm, Volume 7, Issue 4, April 2026.
This graphical abstract shows the antibacterial potential of phytochemicals from 15 spices, showcasing key compounds, their extraction methods, and mechanisms of action. It highlights membrane disruption, ROS generation, enzyme inhibition, and biofilm prevention as core antibacterial pathways.
Hettiyahandi Binodh De Silva, Yanqi Dai, Shervanthi Homer‐Vanniasinkam, Mohan Edirisinghe   +3 more
wiley   +1 more source

The Biochemical Role of Bitter Melon (Momordica charantia L.) Aqueous Extract in Regulating Hepatic Gluconeogenesis in Rats Fed Ketogenic Diet

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Metabolic effects of a ketogenic diet and bitter melon extract on hepatic gluconeogenesis and glucose–lipid homeostasis. ABSTRACT The ketogenic diet (KD) has been suggested as a useful lifestyle intervention for metabolic syndrome; however, its long‐term metabolic effects remain debated.
Ghalia Shamlan
wiley   +1 more source

Beneficial effect of diosgenin as a stimulator of NGF on the brain with neuronal damage induced by Aβ-42 accumulation and neurotoxicant injection

Laboratory Animal Research, 2016
To investigate the beneficial effects of diosgenin (DC) on the multiple types of brain damage induced by Aβ-42 peptides and neurotoxicants, alterations in the specific aspects of brain functions were measured in trimethyltin (TMT)-injected transgenic ...
Eun-Kyoung Koh, Woo-Bin Yun, Ji-Eun Kim, Sung-Hwa Song, Ji-Eun Sung, Hyun-Ah Lee, Eun-Ji Seo, Seung-Wan Jee, Chang-Joon Bae, Dae-Youn Hwang   +9 more
doaj   +1 more source

Natural Products in Cancer Prevention and Therapy: Current Challenges and Future Directions

MedComm, Volume 7, Issue 2, February 2026.
Natural products play a pivotal role in cancer therapy. They induce cancer cell death by reprogramming four metabolic pathways while precisely targeting the tumor microenvironment and immune cells. These compounds not only leverage novel delivery systems for innovative applications but also demonstrate unique therapeutic efficacy across clinical stages:
Ruimiao Qian, Jun Ge, Ni Fan, Zheng Sun, Chengcheng Zhao, Yujiao Sun, Yingpeng Li, Yunfei Li, Hui Fu   +8 more
wiley   +1 more source

Molecular Insights into Fungal Glycosylphosphatidylinositol Transamidase Complex

Advanced Science, Volume 13, Issue 2, 9 January 2026.
The glycosylphosphatidylinositol (GPI) biosynthesis pathway is critical for antifungal drug development. This study reports three cryo‐electron microscopy structures of fungal GPI transamidase (GPIT), captured in two substrate‐bound states and a novel dimeric assembly.
Zhengkang Hua, Xuyang Ding, Yanan Wu, Di Zhang, Xinlin Hu, Ping Yang, Jiameng Li, Yi Tan, Junbo Liu, Mingjie Zhang, Min Zhang, Xiaotian Liu, Hongjun Yu   +12 more
wiley   +1 more source