Results 171 to 180 of about 4,569 (202)
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Diosmetin Induces Apoptosis of Acute Myeloid Leukemia Cells
Molecular Pharmaceutics, 2018Acute myeloid leukemia is an aggressive disease with limited and nonselective therapeutic options. This study explored the bioactivity and cell death inducing mechanism of diosmetin, a novel compound identified in a nutraceutical screen to impart selective anti-AML activity.
Alessia Roma +2 more
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Bioactivation of the phytoestrogen diosmetin by CYP1 cytochromes P450
Cancer Letters, 2009Breast cancer is a major cause of death worldwide. Amongst the various forms of treatment chemoprevention is favoured and natural products such as the dietary flavonoids have been examined for their cancer preventative activity. In this study we investigated the anticancer activity of the flavonoid diosmetin, as a result of cytochrome P450 CYP1 ...
Vasilis, Androutsopoulos +3 more
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Mechanism underlying the vasodilation induced by diosmetin in porcine coronary artery
European Journal of Pharmacology, 2020Diosmetin is a flavonoid present naturally in citrus fruit. Plants containing diosmetin have been reported to have anti-hypertensive and vasorelaxant effects. Therefore, experiments were carried out to study the effects of diosmetin in segments of the porcine coronary artery (PCA).
Taseer, Ahmad +3 more
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ChemInform Abstract: Synthesis of Two New Diosmetin Ethers.
ChemInform, 1996AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
R. MOSQUERA, A. ORJALES
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Diosmetin inhibits the expression of alpha-hemolysin in Staphylococcus aureus
Antonie van Leeuwenhoek, 2015Staphylococcus aureus is a significant human pathogen that causes a wide range of diseases. Alpha-hemolysin (Hla), a pore-forming cytotoxin that is produced by most S. aureus strains, can cause tissue injury and plays a critical role in the virulence of this pathogen.
Liu, Shui +8 more
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Diosmetin alleviates S. aureus-induced mastitis by inhibiting SIRT1/GPX4 mediated ferroptosis
Life Sciences, 2023Microbial infection is the main factor that induces mastitis. Staphylococcus aureus (S. aureus) is a major pathogen associated with mastitis. The purpose of this study was to investigate the effects of diosmetin on S. aureus-induced mastitis.The mice were divided into six groups: control group, S.
Lihua, Zhao, Lei, Jin, Bin, Yang
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Pharmacokinetic studies of diosmin and diosmetin in perfused rat liver
Xenobiotica, 19931. The kinetics and metabolism of diosmin and diosmetin were investigated in the isolated perfused rat liver in order to assess the role of the liver. 2. Diosmetin and especially diosmin disappeared quickly from the perfusion medium. 3. Both flavonoids were rapidly metabolized and diosmetin was partly excreted in bile as the glucuronide and sulphate ...
R, Perego +4 more
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Vietnam Journal of Chemistry
AbstractThe Diosmetin Phytosome (Dt‐Ph) was developed to enhance the complex's aqueous solubility and in vitro drug release compared to pure Diosmetin (Dt). The process variables such as the reactants’ molar ratio, reaction time, stirring speed, and reaction temperature were varied to identify the most appropriate conditions for synthesis.
Thi‐Kim‐Chi Huynh +11 more
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AbstractThe Diosmetin Phytosome (Dt‐Ph) was developed to enhance the complex's aqueous solubility and in vitro drug release compared to pure Diosmetin (Dt). The process variables such as the reactants’ molar ratio, reaction time, stirring speed, and reaction temperature were varied to identify the most appropriate conditions for synthesis.
Thi‐Kim‐Chi Huynh +11 more
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ChemInform Abstract: New Amino and Mercapto Derivatives of Diosmetin
ChemInform, 2000AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A. Orjales, R. Mosquera, G. Canal
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Recent Advances in Diosmetin: Pharmacological, Pharmacokinetic, and Toxicological Profile
Current Topics in Medicinal ChemistryDiosmetin, also known as 3´, 5, 7-trihydroxy-4´-methoxyflavone, is a bioflavonoid that can be found in several food sources. These include mainly citrus fruits and plants, such as Rosmarinus officinalis, Citrus sinensis, Galium verum, and Rosa agrestis.
Bhoopendra Singh +2 more
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