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Inhibition of Cytochrome P450 2C8-mediated Drug Metabolism by the Flavonoid Diosmetin

Drug Metabolism and Pharmacokinetics, 2011
The aim of this study was to assess the effects of diosmetin and hesperetin, two flavonoids present in various medicinal products, on CYP2C8 activity of human liver microsomes using paclitaxel oxidation to 6α-hydroxy-paclitaxel as a probe reaction. Diosmetin and hesperetin inhibited 6α-hydroxy-paclitaxel production in a concentration-dependent manner ...
QUINTIERI, LUIGI   +3 more
openaire   +2 more sources

Fabrication and Characterization of Electrospun Diosmetin‐Loaded Membranes for Enhanced Solubility

ChemistrySelect
Abstract Diosmetin (DT) exhibits various biological activities, including anticancer, antibacterial, antioxidant, estrogenic, and, most notably, anti‐inflammatory properties. Although it has a great deal of promise for advancement in therapeutic usage, DT has yet to be the subject of many applicable investigations in the realm of ...
Thanh Gia‐Thien Ho   +14 more
openaire   +1 more source

Exploring the Multifaceted Potential of Natural Flavonoid Diosmetin in Human Diseases

Current Pharmaceutical Design
Abstract: Flavonoids are secondary metabolites that are closely related to polyphenols and have a diverse structure. These are present in the form of aglycones or glycosides in many fruits and vegetables. Diosmetin (DIO) is a bioactive flavonoid primarily found in the olive tree (Olea europaea L) and has been recognised for its diverse therapeutic ...
Dhirendra Singh   +2 more
openaire   +1 more source

Diosmetin attenuates fibromyalgia-like symptoms in a reserpine-induced model in mice

Inflammopharmacology
Fibromyalgia is a potentially disabling idiopathic disease characterized by widespread chronic pain associated with comorbidities such as fatigue, anxiety, and depression. Current therapeutic approaches present adverse effects that limit adherence to therapy.
Lara Panazzolo Marquezin   +6 more
openaire   +2 more sources

Fluorescent carbon dots for highly sensitive diosmetin sensing

Microchemical Journal
Chang Tang   +5 more
openaire   +1 more source

Tricetin, diosmetin and luteolin sulphates in leaves of Lachenalia unifolia

Phytochemistry, 1976
Christine A. Williams   +2 more
openaire   +1 more source

β-Glucuronidase from Helix pomatia origin is not suitable for diosmetin analysis

Journal of Pharmaceutical and Biomedical Analysis, 2010
E, Werner   +2 more
openaire   +2 more sources

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