Results 1 to 10 of about 5,188 (178)

Antiviral potential of diosmin against influenza A virus. [PDF]

Sci Rep
Influenza poses a global health threat. With drug-resistant strains emerging, there is an urgent need for effective antiviral drugs. This study explores antiviral potential of flavonoids against influenza A virus (IAV) and their mechanism of action.
AbuBakar U, Low ZX, Aris MZM, Lani R, Abidin SAZ, Abdullah-Zawawi MR, Hassandarvish P, Karsani SA, Khairat JE.   +8 more
europepmc   +4 more sources

Scientific Opinion on the substantiation of a health claim related to a combination of diosmin, troxerutin and hesperidin and maintenance of normal venous-capillary permeability pursuant to Article 13(5) of Regulation (EC) No 1924/2006 [PDF]

EFSA Journal, 2014
Following an application from Omikron Italia S.r.l., submitted pursuant to Article 13.5 of Regulation (EC) No 1924/2006 via the Competent Authority of Italy, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA)
doaj   +6 more sources

The neuroprotective effects of hesperidin and diosmin in neurological disorders via targeting various signaling pathways. [PDF]

Iran J Basic Med Sci
Diosmin and hesperidin, two flavonoid glycosides derived from citrus plants, offer numerous health benefits, whether used alone or in combination. They can mitigate neurodegenerative symptoms and reduce vascular and microbial inflammations, improving ...
Abharian N, Nikray N, Feizi A, Talebi M, Shafaroodi H, Faizi M.   +5 more
europepmc   +4 more sources

Plant metabolite diosmin as the therapeutic agent in human diseases

Current Research in Pharmacology and Drug Discovery, 2022
Plant-derived flavonoids have been the focus of research for many years mainly in the last decade owing to their therapeutic properties. So far, about 4000 flavonoids have been identified from plants and diosmin (a flavone glycoside) is one of them ...
Saad Mustafa, Mahmood Akbar, Mohammad Aasif Khan, Kumari Sunita, Shabana Parveen, Jogendra Singh Pawar, Sheersh Massey, Nupur Rani Agarwal, Syed Akhtar Husain   +8 more
doaj   +2 more sources

Diosmin mitigates high glucose-induced endoplasmic reticulum stress through PI3K/AKT pathway in HK-2 cells [PDF]

BMC Complementary Medicine and Therapies, 2022
Background Diosmin has been reported to treat diabetes, but its role in diabetic nephropathy (DN) remains unclear. This research investigated the mechanism by which diosmin alleviated high glucose (HG)-induced HK-2 cell injury. Methods First, we used CCK-
Jiuhong Deng, Chao Zheng, Zhou Hua, Haideng Ci, Guiying Wang, Lijing Chen   +5 more
doaj   +2 more sources

Diosmin induces caspase-dependent apoptosis in human glioblastoma cells [PDF]

Anais da Academia Brasileira de Ciências, 2019
: Diosmin is a flavone glycoside clinically used as the main component of Daflon for the treatment of venous diseases. Several studies demonstrated that this natural compound can induce apoptosis in different tumors.
JULIANA M. SOARES, BRUNA M. DE FARIA, LUCAS M. ASCARI, SONIZA V. ALVES-LEON, JORGE M. DE SOUZA, ANTONIO G. SOARES, YRAIMA CORDEIRO, LUCIANA F. ROMÃO   +7 more
doaj   +3 more sources

Diosmin Administration Slightly Counteracted the Changes in Bone Mechanical Properties Induced by Experimental Type 1 Diabetes in Rats. [PDF]

Pharmaceuticals (Basel)
Background: There is interest in substances of plant origin that may have health-promoting effects regarding diabetes and its complications, including increased risk of fractures.
Grzywnowicz K, Londzin P, Klasik-Ciszewska S, Borymska W, Zych M, Kaczmarczyk-Żebrowska I, Folwarczna J.   +6 more
europepmc   +2 more sources

Scientific Opinion on the substantiation of a health claim related to a combination of diosmin, troxerutin and hesperidin and maintenance of normal venous tone pursuant to Article 13(5) of Regulation (EC) No 1924/2006 [PDF]

EFSA Journal, 2014
Following an application from Omikron Italia S.r.l., submitted pursuant to Article 13.5 of Regulation (EC) No 1924/2006 via the Competent Authority of Italy, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA)
doaj   +4 more sources

Comparative study between calcium gluconate with diosmin, cabergoline, and cabergoline with diosmin in prevention of ovarian hyperstimulation syndrome in high-risk women undergoing intracytoplasmic sperm injection (ICSI) procedures. [PDF]

Front Pharmacol
BackgroundOvarian Hyper-stimulation Syndrome (OHSS) is the main iatrogenic problem linked to ovarian stimulation with reproductive medications. Increased vascular permeability is considered the cause of OHSS.
Abdallah AM, Hussien AK, Alarfaj SJ, Elmasry TA, Kamal M, Sarhan H, Mosbeh MH, Sadek EM.   +7 more
europepmc   +2 more sources

Tailored biosynthesis of diosmin through reconstitution of the flavonoid pathway in Nicotiana benthamiana. [PDF]

Front Plant Sci
The flavonoid diosmin (diosmetin 7-O-rutinoside) is used as a therapeutic agent for disorders of the blood vessels such as hemorrhoids and varicose veins. Diosmin is commercially produced using semi-synthetic methods involving the oxidation of hesperidin,
Lee H, Park S, Lee SB, Song J, Kim TH, Kim BG.   +5 more
europepmc   +2 more sources