Heterogeneous Lineages of DNA Transposons Encode a TET/JBP Dioxygenase in Fungi [PDF]
BiologyEpigenetic DNA modification is a key component of the defense system against invading nucleic acids such as transposons. TET/JBP dioxygenases oxidize 5-methylcytosine and lead to its replacement by cytosine in mammals.
Kenji K. Kojima
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Indoleamine 2,3-dioxygenase vaccination [PDF]
OncoImmunology, 2015 Indoleamine 2,3-dioxygenase (IDO) is an immunoregulatory enzyme. Remarkably, we discovered IDO-specific T cells that can influence adaptive immune reactions in patients with cancer. Further, a recent phase I clinical trial demonstrated long-lasting disease stabilization without toxicity in patients with non-small-cell lung cancer (NSCLC) who were ...
Andersen, Mads Hald, Svane, Inge Marie
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Substrate specificity of a branch of aromatic dioxygenases determined by three distinct motifs [PDF]
Nature CommunicationsThe inversion of substrate size specificity is an evolutionary roadblock for proteins. The Duf4243 dioxygenases GedK and BTG13 are known to catalyze the aromatic cleavage of bulky tricyclic hydroquinone.
Chengsen Cui +10 more
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TET dioxygenases localize at splicing speckles and promote RNA splicing [PDF]
NucleusThe dynamic regulation of RNA metabolism plays a crucial part in cellular function, with emerging evidence suggesting an important role for RNA modifications in this process.
Florian D. Hastert +11 more
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PLoS ONE, 2021 Gibberellin-dioxygenases genes plays important roles in the regulating plant development. However, Gibberellin-dioxygenases genes are rarely reported in maize, especially response to gibberellin (GA).
Jiabin Ci +8 more
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Gene Expression during BTEX Biodegradation by a Microbial Consortium Acclimatized to Unleaded Gasoline and a Pseudomonas putida Strain (HM346961) Isolated from It [PDF]
Polish Journal of Microbiology, 2017 Pseudomonas putida strain (HM346961) was isolated from a consortium of bacteria acclimatized to unleaded gasoline-contaminated water. The consortium can efficiently remove benzene, toluene, ethylbenzene and xylene (BTEX) isomers, and a similar capability
Jesús A. Morlett Chávez +4 more
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The Role of Ten-Eleven Translocation Proteins in Inflammation
Frontiers in Immunology, 2022 Ten-eleven translocation proteins (TET1-3) are dioxygenases that oxidize 5-methyldeoxycytosine, thus taking part in passive and active demethylation. TETs have shown to be involved in immune cell development, affecting from self-renewal of stem cells and
Christian Gerecke +3 more
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mSystems, 2019 The release of synthetic chemical pollutants in the environment is posing serious health risks. Enzymes, including oxygenases, play a crucial role in xenobiotic degradation. In the present study, we employed a functional metagenomics approach to overcome
Chandni Sidhu +3 more
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Schizosaccharomyces pombe Ofd2 is a nuclear 2-oxoglutarate and iron dependent dioxygenase interacting with histones. [PDF]
PLoS ONE, 2011 2-Oxoglutarate (2OG) dependent dioxygenases are ubiquitous iron containing enzymes that couple substrate oxidation to the conversion of 2OG to succinate and carbon dioxide.
Hanne Korvald +6 more
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Structure and function of dioxygenases in histone demethylation and DNA/RNA demethylation
IUCrJ, 2014 Iron(II) and 2-oxoglutarate (2OG)-dependent dioxygenases involved in histone and DNA/RNA demethylation convert the cosubstrate 2OG and oxygen to succinate and carbon dioxide, resulting in hydroxylation of the methyl group of the substrates and subsequent
Cheng Dong +4 more
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