Results 11 to 20 of about 1,907 (195)

Benefits of supplementation with diphenyl diselenide in dairy cows in transition period: metabolic, immune and antioxidant effects [PDF]

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
The aim of this study was to evaluate the effects of diphenyl diselenide (PhSe) supplementation during the transition period on the metabolism, immunity, oxidative status, and milk production of postpartum dairy cows.
C.M. Rodrigues, M.L. Moraes, M. Schneider, S.G. Collet, A.M. Prestes, F.W.S. Cibin, V. Gomes, M.G. Blagitz, J.B.T. Rocha, M.L.R. Leal   +9 more
doaj   +2 more sources

Diphenyl diselenide protects against diabetic kidney disease through modulating gut microbiota dysbiosis in streptozotocin-induced diabetic rats [PDF]

Frontiers in Pharmacology
IntroductionDiphenyl diselenide (DPDS) ameliorates nephropathy in streptozotocin (STZ)-induced type 1 diabetic rats by inhibiting oxidative stress and inflammatory reactions.
Xing Wang, Dongmei Long, Xingcan Peng, Jiaxuan Li, Maoting Zhou, Yu Wang, Xianghong Hu   +6 more
doaj   +2 more sources

The solubilization of diphenyl diselenide in surfactant solutions

Journal of Dispersion Science and Technology, 2021
Solubilization of diphenyl diselenide (DPDS) was studied in CTAB, OPE-10 and SDS surfactant solutions at 298 K. Solubility of DPDS increases with increase in the surfactant concentration due to its solubilization in micelles.
Kunal Pawar, R. Jayaram, S. Bhagwat
semanticscholar   +2 more sources

Diphenyl diselenide protects neuronal cells against oxidative stress and mitochondrial dysfunction: Involvement of the glutathione-dependent antioxidant system [PDF]

Redox Biology, 2019
Oxidative stress and mitochondrial dysfunction are critical events in neurodegenerative diseases; therefore, molecules that increase cellular antioxidant defenses represent a future pharmacologic strategy to counteract such conditions.
Ruth Liliám Quispe, Michael Lorenz Jaramillo, Leticia Selinger Galant, Daiane Engel, Alcir Luiz Dafre, João Batista Teixeira da Rocha, Rafael Radi, Marcelo Farina, Andreza Fabro de Bem   +8 more
doaj   +2 more sources

Effect OF m-trifluoromethyl- attachment on the glutathione peroxidase mimicry and antioxidant actions of diphenyl diselenide: Essential thiols of electrogenic sodium pump as a mechanistic component

Advances in Redox Research, 2023
m-Ditrifluoromethyl-diphenyl diselenide [DFDD (m-CF3-C6H4Se)2] is a disubstituted diaryl analog of diphenyl diselenide [DPDS (C6H5Se)2] in which a hydrogen atom on each aromatic ring is replaced by trifluoromethyl group (-CF3).
Ebenezer Morayo Ale, Steve Osagie Asuelimen, Victoria Ifeoluwa Ayo, Mgbede Joy Timothy, Isaac John Umaru, Ebenezer Kayode Toluwalase   +5 more
doaj   +2 more sources

New therapeutic approach: diphenyl diselenide reduces mitochondrial dysfunction in acetaminophen-induced acute liver failure. [PDF]

PLoS ONE, 2013
The acute liver failure (ALF) induced by acetaminophen (APAP) is closely related to oxidative damage and depletion of hepatic glutathione, consequently changes in cell energy metabolism and mitochondrial dysfunction have been observed after APAP overdose.
Nélson R Carvalho, Edovando F da Rosa, Michele H da Silva, Cintia C Tassi, Cristiane L Dalla Corte, Sara Carbajo-Pescador, Jose L Mauriz, Javier González-Gallego, Félix A Soares   +8 more
doaj   +2 more sources

Swimming exercise and diphenyl diselenide-supplemented diet modulate cerebral cortical and striatal GABA uptake in aged rats

Anais da Academia Brasileira de Ciências, 2022
Aging is characterized by several neurochemical modifications involving structural proteins and neurotransmitters. Exercise has been recognized as an enhancer of overall health; whereas, diphenyl diselenide (PhSe)2 has been reported to have antioxidant ...
ANA PAULA PESARICO, JOSÉ L. CECHELLA, CRISTINA W. NOGUEIRA, SUZAN G. ROSA   +3 more
doaj   +2 more sources

Metabolic and hematological disruptions induced by Diphenyl Diselenide in male wistar rats

The Proceedings of the Nigerian Academy of Science
Diphenyldiselenide (DPDS), a potent antioxidant and enzyme inhibitor, exerts cellular toxicity mainly through interaction with thiol group of proteins. This study evaluates its toxicity on glycolysis and gluconeogenesis as well as on some hematological ...
Joseph A. Olagunju, Gabriel O. Ajayi, Babatunde A. Murtala, Adejuwan A. Adeneye   +3 more
doaj   +2 more sources

Free radical scavenging in vitro and biological activity of diphenyl diselenide-loaded nanocapsules: DPDS-NCS antioxidant and toxicological effects [PDF]

International Journal of Nanomedicine, 2015
Sílvio Terra Stefanello,1 Fernando Dobrachinski,1 Nélson Rodrigues de Carvalho,1 Guilherme Pires Amaral,1 Rômulo Pillon Barcelos,1 Vitor Antunes Oliveira,1 Cláudia Sirlene Oliveira,1 Camila Ferrazza Alves Giordani,2 Maria Ester
Stefanello ST, Dobrachinski F, Carvalho NR, Amaral GP, Barcelos RP, Oliveira VA, Oliveira CS, Giordani CFA, Pereira ME, Rodrigues OED, Soares FAA   +10 more
doaj   +2 more sources

Diphenyl Diselenide and SARS-CoV-2: in silico Exploration of the Mechanisms of Inhibition of Main Protease (M^pro) and Papain-like Protease (PL^pro). [PDF]

J Chem Inf Model, 2023
The SARS-CoV-2 pandemic has prompted global efforts to develop therapeutics. The main protease of SARS-CoV-2 (Mpro) and the papain-like protease (PLpro) are essential for viral replication and are key targets for therapeutic development. In this work, we
Omage FB, Madabeni A, Tucci AR, Nogara PA, Bortoli M, Rosa ADS, Neuza Dos Santos Ferreira V, Teixeira Rocha JB, Miranda MD, Orian L.   +9 more
europepmc   +2 more sources