Results 1 to 10 of about 1,191,834 (315)

Association between genetically proxied PPARG activation and early onset Alzheimer's disease: A drug target Mendelian randomization study

Journal of Alzheimer's Disease Reports
Background:  Early-onset Alzheimer's disease (EOAD), which has an onset before the age of 65, is overshadowed by the more prevalent late-onset Alzheimer's disease (LOAD).
Lingyu Zhang, Yi Wu, Qianqian Jin, Chunfang Wang   +3 more
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Lipopolysaccharide Increases Immune Activation and Alters T Cell Homeostasis in SHIVB’WHU Chronically Infected Chinese Rhesus Macaque

Journal of Immunology Research, 2015
Immune activation plays a significant role in the disease progression of HIV. Microbial products, especially bacterial lipopolysaccharide (LPS), contribute to immune activation.
Gao-Hong Zhang, Run-Dong Wu, Hong-Yi Zheng, Xiao-Liang Zhang, Ming-Xu Zhang, Ren-Rong Tian, Guang-Ming Liu, Wei Pang, Yong-Tang Zheng   +8 more
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Calcineurin Antagonizes AMPK to Regulate Lipolysis in Caenorhabditis elegans

Molecules, 2017
Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase, and the target of immunosuppressive agent tacrolimus (TAC).
Yanli Wang, Cangsang Xie, Zhiqing Diao, Bin Liang   +3 more
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Flu‐CED: A comparative transcriptomics database of influenza virus‐infected human and animal models

Animal Models and Experimental Medicine
Background The continuing emergence of influenza virus has highlighted the value of public databases and related bioinformatic analysis tools in investigating transcriptomic change caused by different influenza virus infections in human and animal models.
Yue Wu, Jue Wang, Jing Xue, Zhiguang Xiang, Jianguo Guo, Lingjun Zhan, Qiang Wei, Qi Kong   +7 more
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Shared genetic architecture and causal relationship between sleep behaviors and lifespan

Translational Psychiatry
Poor sleep health is associated with a wide array of increased risk for cardiovascular, metabolic and mental health problems as well as all-cause mortality in observational studies, suggesting potential links between sleep health and lifespan.
Yong Wu, Chu-Yi Zhang, Xiaolan Liu, Lu Wang, Ming Li, Yi Li, Xiao Xiao   +6 more
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Transcriptome Data and Comparative Medical Analysis of COVID-19 Virus Infection

Shiyan dongwu yu bijiao yixue
ObjectiveTo provide more basic information of comparative medicine for the study of biological changes and pathogenesis of COVID-19 by systematical sorting and analyzing the transcriptome data. Methods Following a retrieval strategy, using COVID-
FENG Tingting, LI Yitong, WU Yue, WANG Jue, KONG Qi   +4 more
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miR-133b targets NCAPH to promote β-catenin degradation and reduce cancer stem cell maintenance in non-small cell lung cancer

Signal Transduction and Targeted Therapy, 2021
Qiuxia Xiong, Liping Jiang, Kun Liu, Xiulin Jiang, Baiyang Liu, Yulin Shi, Dating Cheng, Yong Duan, Cuiping Yang, Yongbin Chen   +9 more
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Correction: Jargalsaikhan et al. The Era of Gene Therapy: The Advancement of Lentiviral Vectors and Their Pseudotyping. Viruses 2025, 17, 1036

Viruses
In the original publication [...]
Bat-Erdene Jargalsaikhan, Masanaga Muto, Masatsugu Ema   +2 more
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The Era of Gene Therapy: The Advancement of Lentiviral Vectors and Their Pseudotyping

Viruses
Over 35 years of history, the field of gene therapy has undergone much progress. The initial concept—the replacement of dysfunctional genes with correct ones—has advanced to the next stage and reached the level of precise genome editing.
Bat-Erdene Jargalsaikhan, Masanaga Muto, Masatsugu Ema   +2 more
doaj   +1 more source

ATM deficiency drives phenotypic diversity and Purkinje cell degeneration in a macaque model of ataxia-telangiectasia

Cell Reports Medicine
Summary: Ataxia-telangiectasia (A-T) is a hereditary neurodegenerative disorder caused by mutations in the ATM (ataxia-telangiectasia mutated) gene. Although existing rodent models reproduce some of the multi-systemic features of A-T, they notably fail ...
Kaiyu Xu, Ying Zhang, Yongxuan Chen, Xiaojia Zhu, Yu Li, Longbao Lv, Xiechao He, Zhengfei Hu, Yifan Li, Maosen Ye, Dewei Jiang, Zhanlong He, Weihua Jin, Yanyan Li, Xiaomei Yu, Deng-Feng Zhang, Karl Herrup, Ping Zheng, Yong-Gang Yao, Dong-Dong Wu, Jiali Li   +20 more
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