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Research Models for Studying Vascular Calcification [PDF]
Calcification of the vessel wall contributes to high cardiovascular morbidity and mortality. Vascular calcification (VC) is a systemic disease with multifaceted contributing and inhibiting factors in an actively regulated process.
Babic, Milen+4 more
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Animal Models of Human Disease [PDF]
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).The use of ...
Inal, Jameel, Lange, Sigrun
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Circadian Disruption and Metabolic Disease: Findings from Animal Models [PDF]
Social opportunities and work demands have caused humans to become increasingly active during the late evening hours, leading to a shift from the predominantly diurnal lifestyle of our ancestors to a more nocturnal one.
Arble, Deanna M.+3 more
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Viral-induced neurodegenerative disease. [PDF]
Viral etiology has been postulated in a variety of neurological diseases in humans, including multiple sclerosis. Several experimental animal models of viral-induced neurodegenerative disease provide insight into potential host- and pathogen-dependent ...
Buchmeier, MJ, Lane, TE
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Urinary peptidomics provides a noninvasive humanized readout of diabetic nephropathy in mice [PDF]
Nephropathy is among the most frequent complications of diabetes and the leading cause of end-stage renal disease. Despite the success of novel drugs in animal models, the majority of the subsequent clinical trials employing those drugs targeting ...
Bascands, Jean-Loup+9 more
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Objective This study was conducted with sera from patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and arthritis and lupus-like disease animal models to identify innate immune system-dependent and -independent ...
Burmester, G.+5 more
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The genetics of cardiovascular disease [PDF]
Recent advances in genotyping technology and insights into disease mechanisms have increased interest in the genetics of cardiovascular disease. Several candidate genes involved in cardiovascular diseases were identified from studies using animal models,
Abu-Amero+72 more
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Animal Models of Parkinson’s Disease [PDF]
Parkinson\u27s disease (PD) is a neurodegenerative disorder characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta, the consequent dopamine deficit in the striatum and the accumulation of aggregated α‐synuclein (α‐
Blesa, Javier+3 more
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Positron Emission Tomography in Animal Models of Alzheimer's Disease Amyloidosis: Translational Implications [PDF]
Animal models of Alzheimer's disease amyloidosis that recapitulate cerebral amyloid-beta pathology have been widely used in preclinical research and have greatly enabled the mechanistic understanding of Alzheimer's disease and the development of ...
Ni, Ruiqing
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Animal Models in Behçet's Disease [PDF]
Behçet's disease is a chronic, recurrent, multisystemic, inflammatory disorder affecting mainly the oral and urogenital mucosa and the uveal tract. Although the etiology and pathogenesis of Behçet's disease are unknown, numerous etiologies have been ...
Yildirim, Ozlem
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