Results 1 to 10 of about 3,982,270 (362)
Neutrophils in animal models of autoimmune disease [PDF]
, 2016 Neutrophils have traditionally been thought to play only a peripheral role in the genesis of many autoimmune and inflammatory diseases. However, recent studies in a variety of animal models suggest that these cells are central to the initiation and ...
Abram +151 more
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Nature Communications, 2020 Circular RNAs are expressed in the brain and show age-dependent expression patterns. Here the authors show the circGRIA1 is expressed in an age-dependent manner in the male macaque brain and serves a functional role in synaptic plasticity.
Kaiyu Xu +11 more
doaj +1 more source
The relevance of non-human primate and rodent malaria models for humans [PDF]
, 2011 At the 2010 Keystone Symposium on "Malaria: new approaches to understanding Host-Parasite interactions", an extra scientific session to discuss animal models in malaria research was convened at the request of participants.
Didier Leroy +11 more
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Transcriptome-wide association study identifies new susceptibility genes and pathways for depression
Translational Psychiatry, 2021 Depression is the most prevalent mental disorder with substantial morbidity and mortality. Although genome-wide association studies (GWASs) have identified multiple risk variants for depression, due to the complicated gene regulatory mechanisms and ...
Xiaoyan Li +7 more
doaj +1 more source
Translatability score revisited: differentiation for distinct disease areas [PDF]
, 2017 Background: Translational science supports successful transition of early biomedical research into human applications. In 2009 a translatability score to assess risk and identify strengths and weaknesses of a given project has been designed and ...
Wehling, Martin, Wendler, Alexandra
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Large Animal Models: The Key to Translational Discovery in Digestive Disease Research
Cellular and Molecular Gastroenterology and Hepatology, 2016 Gastrointestinal disease is a prevalent cause of morbidity and mortality and the use of animal models have been instrumental in studying mechanisms of digestive pathophysiology.
A. Ziegler, L. Gonzalez, A. Blikslager
semanticscholar +1 more source
Signal Transduction and Targeted Therapy, 2021 SARS-CoV-2 has been reported to show a capacity for invading the brains of humans and model animals. However, it remains unclear whether and how SARS-CoV-2 crosses the blood–brain barrier (BBB).
Ling Zhang +20 more
doaj +1 more source
A Zebrafish Model of Mycobacterium leprae Granulomatous Infection. [PDF]
, 2017 Understanding the pathogenesis of leprosy granulomas has been hindered by a paucity of tractable experimental animal models. Mycobacterium leprae, which causes leprosy, grows optimally at approximately 30°C, so we sought to model granulomatous disease in
Cameron, James +2 more
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Large animal models of cardiovascular disease
Cell Biochemistry and Function, 2016 The human cardiovascular system is a complex arrangement of specialized structures with distinct functions. The molecular landscape, including the genome, transcriptome and proteome, is pivotal to the biological complexity of both normal and abnormal ...
H. Tsang +5 more
semanticscholar +1 more source
A tetraspecific VHH-based neutralizing antibody modifies disease outcome in three animal models of Clostridium difficile infection [PDF]
, 2016 Clostridium difficile infection (CDI), a leading cause of nosocomial infection, is a serious disease in North America, Europe, and Asia. CDI varies greatly from asymptomatic carriage to life-threatening diarrhea, toxic megacolon, and toxemia.
Beamer, Gillian +12 more
core +2 more sources