Results 1 to 10 of about 3,815,237 (315)
Human disease models in drug development
Nature Reviews Bioengineering, 2023 Biomedical research is undergoing a paradigm shift towards approaches centred on human disease models owing to the notoriously high failure rates of the current drug development process.
Anna Loewa, James J Feng, S. Hedtrich
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Advantages and Progress of Using Chinese Hamsters to Construct Disease Models
Shiyan dongwu yu bijiao yixue, 2021 Chinese hamsters are experimental animals originally from China. They play an important role in experimental research on medicine and biology. They are widely used in life science research, such as genetics, infectious diseases, tissue culture ...
GAO Jiping +4 more
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Frontiers in Immunology, 2021 C1q/TNF-related proteins (CTRP) including CTRP3 are a group of secreted proteins which have a complement C1q-like domain in common, and play versatile roles in lipid metabolism, inflammation, tumor metastasis and bone metabolism.
Masanori A. Murayama +5 more
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Animal Models of Parkinson’s Disease
The Hidden Life of the Basal Ganglia, 2021 Parkinson's disease (PD) is a neurodegenerative disorder characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta, the consequent dopamine deficit in the striatum and the accumulation of aggregated α‐ synuclein (α ...
I. T. Damas +2 more
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Nature Communications, 2021 TARM1 is a LILR family member that drives cell signalling via interactions with FcRγ. Here the authors show that TARM1 binds collagens to activate dendritic cells and thereby is an effector of inflammatory arthritis, plus provide a soluble TARM-Fc fusion
Rikio Yabe +10 more
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Animal models of Alzheimer’s disease: Applications, evaluation, and perspectives
Zoological Research, 2022 Although great advances in elucidating the molecular basis and pathogenesis of Alzheimer’s disease (AD) have been made and multifarious novel therapeutic approaches have been developed, AD remains an incurable disease.
Zhi-Ya Chen, Yan Zhang
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Animal Models of Depression: What Can They Teach Us about the Human Disease?
Diagnostics, 2021 Depression is apparently the most common psychiatric disease among the mood disorders affecting about 10% of the adult population. The etiology and pathogenesis of depression are still poorly understood.
Maria Becker, A. Pinhasov, A. Ornoy
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CD166-specific CAR-T cells potently target colorectal cancer cells
Translational Oncology, 2023 Chimeric antigen receptor (CAR) T-cell therapy is emerging as an effective cancer treatment, such as for hematological malignancies, however its effectiveness as an approach to treat solid tumors, such as in colorectal cancer (CRC), remains to be better ...
Shuai He +8 more
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The role of m6A modification in the biological functions and diseases
Signal Transduction and Targeted Therapy, 2021 N6-methyladenosine (m6A) is the most prevalent, abundant and conserved internal cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells.
Xiulin Jiang +7 more
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Research Models for Studying Vascular Calcification [PDF]
, 2020 Calcification of the vessel wall contributes to high cardiovascular morbidity and mortality. Vascular calcification (VC) is a systemic disease with multifaceted contributing and inhibiting factors in an actively regulated process.
Babic, Milen +4 more
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