Results 1 to 10 of about 3,865,310 (362)
Animal models of Wilson disease [PDF]
Journal of Neurochemistry, 2018 Wilson disease (WD) is an autosomal recessive disorder of copper metabolism manifesting with hepatic, neurological and psychiatric symptoms. The limitations of the currently available therapy for WD (particularly in the management of neuropsychiatric ...
E. Reed, S. Lutsenko, O. Bandmann
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Human disease models in drug development
Nature Reviews Bioengineering, 2023 Biomedical research is undergoing a paradigm shift towards approaches centred on human disease models owing to the notoriously high failure rates of the current drug development process.
Anna Loewa, James J Feng, S. Hedtrich
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Advantages and Progress of Using Chinese Hamsters to Construct Disease Models
Shiyan dongwu yu bijiao yixue, 2021 Chinese hamsters are experimental animals originally from China. They play an important role in experimental research on medicine and biology. They are widely used in life science research, such as genetics, infectious diseases, tissue culture ...
GAO Jiping +4 more
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Frontiers in Immunology, 2021 C1q/TNF-related proteins (CTRP) including CTRP3 are a group of secreted proteins which have a complement C1q-like domain in common, and play versatile roles in lipid metabolism, inflammation, tumor metastasis and bone metabolism.
Masanori A. Murayama +5 more
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Animal models of Parkinson’s disease [PDF]
The FEBS Journal, 2012 Animal models of Parkinson’s disease (PD) have been widely used in the past four decades to investigate the pathogenesis and pathophysiology of this neurodegenerative disorder. These models have been classically based on the systemic or local (intracerebral) administration of neutoxins that are able to replicate most of the pathological and phenotypic ...
Blandini F., Armentero M. -T.
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Animal Models of Parkinson’s Disease
The Hidden Life of the Basal Ganglia, 2021 Parkinson's disease (PD) is a neurodegenerative disorder characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta, the consequent dopamine deficit in the striatum and the accumulation of aggregated α‐ synuclein (α ...
I. T. Damas +2 more
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Nature Communications, 2021 TARM1 is a LILR family member that drives cell signalling via interactions with FcRγ. Here the authors show that TARM1 binds collagens to activate dendritic cells and thereby is an effector of inflammatory arthritis, plus provide a soluble TARM-Fc fusion
Rikio Yabe +10 more
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Animal models of Alzheimer’s disease: Applications, evaluation, and perspectives
Zoological Research, 2022 Although great advances in elucidating the molecular basis and pathogenesis of Alzheimer’s disease (AD) have been made and multifarious novel therapeutic approaches have been developed, AD remains an incurable disease.
Zhi-Ya Chen, Yan Zhang
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Animal Models of Depression: What Can They Teach Us about the Human Disease?
Diagnostics, 2021 Depression is apparently the most common psychiatric disease among the mood disorders affecting about 10% of the adult population. The etiology and pathogenesis of depression are still poorly understood.
Maria Becker, A. Pinhasov, A. Ornoy
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Parathyroid Diseases and Animal Models [PDF]
Frontiers in Endocrinology, 2012 CIRCULATING CALCIUM AND PHOSPHATE ARE TIGHTLY REGULATED BY THREE HORMONES: the active form of vitamin D (1,25-dihydroxyvitamin D), fibroblast growth factor (FGF)-23, and parathyroid hormone (PTH). PTH acts to stimulate a rapid increment in serum calcium and has a crucial role in calcium homeostasis. Major target organs of PTH are kidney and bone.
Imanishi, Yasuo +2 more
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