Results 1 to 10 of about 1,810,523 (315)

Advantages and Progress of Using Chinese Hamsters to Construct Disease Models

open access: yesShiyan dongwu yu bijiao yixue, 2021
Chinese hamsters are experimental animals originally from China. They play an important role in experimental research on medicine and biology. They are widely used in life science research, such as genetics, infectious diseases, tissue culture ...
GAO Jiping   +4 more
doaj   +1 more source

The CTRP3-AdipoR2 Axis Regulates the Development of Experimental Autoimmune Encephalomyelitis by Suppressing Th17 Cell Differentiation

open access: yesFrontiers in Immunology, 2021
C1q/TNF-related proteins (CTRP) including CTRP3 are a group of secreted proteins which have a complement C1q-like domain in common, and play versatile roles in lipid metabolism, inflammation, tumor metastasis and bone metabolism.
Masanori A. Murayama   +5 more
doaj   +1 more source

TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens

open access: yesNature Communications, 2021
TARM1 is a LILR family member that drives cell signalling via interactions with FcRγ. Here the authors show that TARM1 binds collagens to activate dendritic cells and thereby is an effector of inflammatory arthritis, plus provide a soluble TARM-Fc fusion
Rikio Yabe   +10 more
doaj   +1 more source

CD166-specific CAR-T cells potently target colorectal cancer cells

open access: yesTranslational Oncology, 2023
Chimeric antigen receptor (CAR) T-cell therapy is emerging as an effective cancer treatment, such as for hematological malignancies, however its effectiveness as an approach to treat solid tumors, such as in colorectal cancer (CRC), remains to be better ...
Shuai He   +8 more
doaj   +1 more source

The role of m6A modification in the biological functions and diseases

open access: yesSignal Transduction and Targeted Therapy, 2021
N6-methyladenosine (m6A) is the most prevalent, abundant and conserved internal cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells.
Xiulin Jiang   +7 more
doaj   +1 more source

Research Models for Studying Vascular Calcification [PDF]

open access: yes, 2020
Calcification of the vessel wall contributes to high cardiovascular morbidity and mortality. Vascular calcification (VC) is a systemic disease with multifaceted contributing and inhibiting factors in an actively regulated process.
Babic, Milen   +4 more
core   +1 more source

Functional genomics elucidates regulatory mechanisms of Parkinson’s disease-associated variants

open access: yesBMC Medicine, 2022
Background Genome-wide association studies (GWASs) have identified multiple risk loci for Parkinson’s disease (PD). However, identifying the functional (or potential causal) variants in the reported risk loci and elucidating their roles in PD ...
Rui Chen   +8 more
doaj   +1 more source

Transcription Factor ZNF683 Inhibits SIV/HIV Replication through Regulating IFNγ Secretion of CD8+ T Cells

open access: yesViruses, 2022
Pulmonary microbial invasion frequently occurs during AIDS progression in HIV patients. Inflammatory cytokines and other immunoregulatory factors play important roles in this process.
Ying Lu   +6 more
doaj   +1 more source

Similarities and differences in placental development between humans and cynomolgus monkeys

open access: yesReproductive Medicine and Biology, 2023
Background The placenta is an extraembryonic organ, which is essential to maintain a normal pregnancy. However, placental development in humans is poorly understood because of technical and ethical reasons. Methods We analyzed the anatomical localization
Shoma Matsumoto   +3 more
doaj   +1 more source

Functional genomic analysis delineates regulatory mechanisms of GWAS-identified bipolar disorder risk variants

open access: yesGenome Medicine, 2022
Background Genome-wide association studies (GWASs) have identified multiple risk loci for bipolar disorder (BD). However, pinpointing functional (or causal) variants in the reported risk loci and elucidating their regulatory mechanisms remain challenging.
Rui Chen   +8 more
doaj   +1 more source

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