Results 1 to 10 of about 2,973,956 (168)
Human disease models in drug development
Nature Reviews Bioengineering, 2023 Biomedical research is undergoing a paradigm shift towards approaches centred on human disease models owing to the notoriously high failure rates of the current drug development process.
Anna Loewa, James J Feng, S. Hedtrich
semanticscholar +1 more source
Advantages and Progress of Using Chinese Hamsters to Construct Disease Models
Shiyan dongwu yu bijiao yixue, 2021 Chinese hamsters are experimental animals originally from China. They play an important role in experimental research on medicine and biology. They are widely used in life science research, such as genetics, infectious diseases, tissue culture ...
GAO Jiping +4 more
doaj +1 more source
Frontiers in Immunology, 2021 C1q/TNF-related proteins (CTRP) including CTRP3 are a group of secreted proteins which have a complement C1q-like domain in common, and play versatile roles in lipid metabolism, inflammation, tumor metastasis and bone metabolism.
Masanori A. Murayama +5 more
doaj +1 more source
Animal Models of Parkinson’s Disease
The Hidden Life of the Basal Ganglia, 2021 Parkinson's disease (PD) is a neurodegenerative disorder characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta, the consequent dopamine deficit in the striatum and the accumulation of aggregated α‐ synuclein (α ...
I. T. Damas +2 more
semanticscholar +1 more source
Nature Communications, 2021 TARM1 is a LILR family member that drives cell signalling via interactions with FcRγ. Here the authors show that TARM1 binds collagens to activate dendritic cells and thereby is an effector of inflammatory arthritis, plus provide a soluble TARM-Fc fusion
Rikio Yabe +10 more
doaj +1 more source
Animal models of Alzheimer’s disease: Applications, evaluation, and perspectives
Zoological Research, 2022 Although great advances in elucidating the molecular basis and pathogenesis of Alzheimer’s disease (AD) have been made and multifarious novel therapeutic approaches have been developed, AD remains an incurable disease.
Zhi-Ya Chen, Yan Zhang
semanticscholar +1 more source
CD166-specific CAR-T cells potently target colorectal cancer cells
Translational Oncology, 2023 Chimeric antigen receptor (CAR) T-cell therapy is emerging as an effective cancer treatment, such as for hematological malignancies, however its effectiveness as an approach to treat solid tumors, such as in colorectal cancer (CRC), remains to be better ...
Shuai He +8 more
doaj +1 more source
The role of m6A modification in the biological functions and diseases
Signal Transduction and Targeted Therapy, 2021 N6-methyladenosine (m6A) is the most prevalent, abundant and conserved internal cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells.
Xiulin Jiang +7 more
doaj +1 more source
Similarities and differences in placental development between humans and cynomolgus monkeys
Reproductive Medicine and Biology, 2023 Background The placenta is an extraembryonic organ, which is essential to maintain a normal pregnancy. However, placental development in humans is poorly understood because of technical and ethical reasons. Methods We analyzed the anatomical localization
Shoma Matsumoto +3 more
doaj +1 more source
Viruses, 2022 Pulmonary microbial invasion frequently occurs during AIDS progression in HIV patients. Inflammatory cytokines and other immunoregulatory factors play important roles in this process.
Ying Lu +6 more
doaj +1 more source