Results 1 to 10 of about 9,939 (132)
Toxins, 2021 Snake envenomation can result in hemorrhage, local necrosis, swelling, and if not treated properly can lead to adverse systemic effects such as coagulopathy, nephrotoxicity, neurotoxicity, and cardiotoxicity, which can result in death.
Shelby S. Szteiter +10 more
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Frontiers in Molecular Biosciences, 2021 Disintegrins are small cysteine-rich proteins found in a variety of snake venom. These proteins selectively modulate integrin function, heterodimeric receptors involved in cell-cell and cell-matrix interaction that are widely studied as therapeutic ...
Ariana A. Vasconcelos +7 more
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A Disintegrin and Metalloprotease (ADAM): Historical Overview of Their Functions
Toxins, 2016 Since the discovery of the first disintegrin protein from snake venom and the following identification of a mammalian membrane-anchored metalloprotease-disintegrin implicated in fertilization, almost three decades of studies have identified additional ...
Nives Giebeler, Paola Zigrino
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Cell Communication and Signaling, 2019 Background Integrins mediate cell adhesion, migration, and survival by connecting the intracellular machinery with the surrounding extracellular matrix. Previous studies demonstrated the interaction between αvβ3 integrin and VEGF type 2 receptor (VEGFR2)
Taís M. Danilucci +7 more
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Journal of Venomous Animals and Toxins including Tropical Diseases, 2018 Background In recent decades, snake venom disintegrins have received special attention due to their potential use in anticancer therapy. Disintegrins are small and cysteine-rich proteins present in snake venoms and can interact with specific integrins to
Isadora Sousa de Oliveira +8 more
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Lebein, a Snake Venom Disintegrin, Induces Apoptosis in Human Melanoma Cells
Toxins, 2016 Melanoma, the most threatening form of skin cancer, has a very poor prognosis and is characterized by its very invasive and chemoresistant properties.
Manel B. Hammouda +8 more
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Snake venom metalloproteinases and disintegrins: interactions with cells [PDF]
Brazilian Journal of Medical and Biological Research, 1998 Metalloproteinases and disintegrins are important components of most viperid and crotalid venoms. Large metalloproteinases referred to as MDC enzymes are composed of an N-terminal Metalloproteinase domain, a Disintegrin-like domain and a Cys-rich C ...
Kamiguti A.S. +2 more
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Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases
Mediators of Inflammation, 2017 Cell migration is an instrumental process involved in organ development, tissue homeostasis, and various physiological processes and also in numerous pathologies.
D. Dreymueller +3 more
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ADAM15 Disintegrin Is Associated with Aggressive Prostate and Breast Cancer Disease
Neoplasia: An International Journal for Oncology Research, 2006 The aim of the current study was to evaluate the expression of ADAM15 disintegrin (ADAM15) in a broad spectrum of human tumors. The transcript for ADAM15 was found to be highly upregulated in a variety of tumor cDNA expression arrays.
Rainer Kuefer +9 more
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Ex vivo STUDY OF THE ACTION OF INTEGRIN RECEPTORS ANTAGONIST FROM ECHIS MULTISQUAMATIS SNAKE VENOM ON PLATELETS OF PREGNANT WOMEN WITH COMPICATIONS DURING GESTATION [PDF]
Biotechnologia Acta, 2023 Aim. In our work, we studied platelet aggregation in blood plasma of pregnant women and estimated the possibility of ex vivo normalization of aggregation rate using a polypeptide from the Echis multisquamatus snake venom.
O. M. PLATONOV, I. V. US
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