Results 111 to 120 of about 51,218 (319)

Intelligent Manufacturing for Osteoarthritis Organoids

Cell Proliferation, EarlyView.
Overall schematic of intelligent manufacturing in osteoarthritis organoids. Broad overview of the article's structure, outlining the progression from fundamental joint anatomy and OA pathogenesis to organoid construction and, ultimately, to intelligent manufacturing and future prospects.
Xukun Lyu, Jian Wang, Jiacan Su
wiley   +1 more source

A patient-derived orthotopic xenograft (PDOX) mouse model of a cisplatinum-resistant osteosarcoma lung metastasis that was sensitive to temozolomide and trabectedin: implications for precision oncology. [PDF]

, 2017
In the present study, we evaluated the efficacy of trabectedin (TRAB) and temozolomide (TEM) compared to cisplatinum (CDDP) on a patient-derived orthotopic xenogrraft (PDOX) of a lung-metastasis from an osteosarcoma of a patient who failed CDDP therapy ...
Dry, Sarah M, Eilber, Fritz C, Elliott, Irmina, Hoffman, Robert M, Igarashi, Kentaro, Kawaguchi, Kei, Kiyuna, Tasuku, Li, Yunfeng, Miyake, Kentaro, Murakami, Takashi, Nelson, Scott D, Russell, Tara A, Singh, Arun S, Tsuchiya, Hiroyuki, Yanagawa, Jane, Zhang, Yong   +15 more
core   +1 more source

A disintegrin and metalloproteinases 10 and 17 modulate the immunogenicity of glioblastoma-initiating cells.

Neuro-Oncology, 2014
BACKGROUND There are emerging reports that the family of a disintegrin and metalloproteinases (ADAM) are involved in the maintenance of the malignant phenotype of glioblastomas.
F. Wolpert, Isabel Tritschler, Alexander Steinle, M. Weller, G. Eisele   +4 more
semanticscholar   +1 more source

Engineering Intervertebral Disc Regeneration: Biomaterials, Cell Sources and Animal Models

Cell Proliferation, EarlyView.
This review highlights the current tissue engineering approaches utilising biomaterials, animal models and cell sources for intervertebral disc regeneration and discusses future opportunities. ABSTRACT Intervertebral disc (IVD) degeneration is an age‐related problem triggering chronic spinal issues, such as low back pain and IVD herniation.
Sidong Yang, Farhad Soheilmoghaddam, Peter Pivonka, Joan Li, Samuel Rudd, Trifanny Yeo, Ji Tu, Yibo Zhu, Justin J. Cooper‐White   +8 more
wiley   +1 more source

Increased plasma von Willebrand factor antigen levels but normal von Willebrand factor cleaving protease (ADAMTS13) activity in preeclampsia. [PDF]

, 2009
The activity of ADAMTS13, the von Willebrand factor (VWF) cleaving protease is low in several conditions, including HELLP (haemolysis, elevated liver enzymes, and low platelet count) syndrome.
Bõze, Tamás, Cervenak, László, Derzsy, Zoltán, Gombos, Tímea, Hársfalvi, Jolán, Makó, Veronika, Molvarec, Attila, Prohászka, Zoltán, Rigó, János, Udvardy, Miklós László   +9 more
core   +1 more source

P10.02 EFFECT OF INTEGRIN-EXTRACELLULAR MATRIX INTERACTIONS ON SMALL ARTERY STRUCTURE AND MECHANICS DURING HYPERTENSION AND AGING

Artery Research, 2009
An age-related increase in systolic blood pressure and similarities in the consequences of hypertension and aging on arterial structure/mechanics have been reported, particularly in larger arteries.
K.R. Parmar, E.H. Heerkens, A.M. Heagerty   +2 more
doaj   +1 more source

Proteomic associations with fluctuation and long‐term changes in BMI: A 40‐year follow‐up study

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Introduction While some studies have explored associations between weight change and blood proteins, most have been intervention‐based, offering limited insight into proteomic associations with long‐term weight gain. It remains unclear whether plasma proteins are related to BMI fluctuation over time.
Alvaro Obeso, Gabin Drouard, Teemu Palviainen, Xiaoling Wang, Miina Ollikainen, Karri Silventoinen, Jaakko Kaprio   +6 more
wiley   +1 more source

Single injection of intra‐articular autologous protein solution in horses with acute interleukin‐1B‐induced synovitis decreases joint pathology scores

Equine Veterinary Journal, Volume 57, Issue 3, Page 806-816, May 2025.
Abstract Background Autologous protein solution (APS) has been shown to decrease lameness in horses with osteoarthritis (OA). Synovitis is an early driver of OA, providing an opportunity to intervene in the progression of disease via intra‐articular (IA) therapeutics.
Alexandra Usimaki, Sarah A. Ciamillo, Dhvani Barot, Renata L. Linardi, Julie B. Engiles, Kyla F. Ortved   +5 more
wiley   +1 more source

CD9 controls integrin α5β1-mediated cell adhesion by modulating its association with the metalloproteinase ADAM17 [PDF]

, 2018
Integrin α5β1 is a crucial adhesion molecule that mediates the adherence of many cell types to the extracellular matrix through recognition of its classic ligand fibronectin as well as to other cells through binding to an alternative counter-receptor ...
Cabañas, Carlos, Cardeñes, Beatriz, Grötzinger, Joachim, Lorenzen, Inken, López-Martín, Soraya, Machado-Pineda, Yesenia, Reyes, Raquel, Suarez, Henar, Sánchez-Organero, Paula, Toribio, Víctor, Yáñez-Mó, María   +10 more
core   +3 more sources

A review of the equine suspensory ligament: Injury prone yet understudied

Equine Veterinary Journal, EarlyView.
Abstract The suspensory ligament (SL) is a key component of the elaborate and highly adapted suspensory apparatus in the horse. In addition to contributing to stabilisation of the metacarpophalangeal joint, the SL has a spring like function to reduce the energetic cost of locomotion.
Deborah J. Guest, Helen L. Birch, Chavaunne T. Thorpe   +2 more
wiley   +1 more source