Results 31 to 40 of about 78,401 (264)
Intracellular Processing of Metalloprotease Disintegrin ADAM12 [PDF]
Journal of Biological Chemistry, 2002 ADAM12 has been implicated in cell-cell interactions in myogenesis and cancer, but the structure of the mature form of ADAM12 is not known, and its localization on the cell surface has been questioned. In this report, we show that full-length ADAM12 is N-glycosylated in the endoplasmic reticulum (ER) and proteolytically processed in the trans-Golgi ...
Yi, Cao +3 more
openaire +2 more sources
TLR ligand-induced podosome disassembly in dendritic cells is ADAM17 dependent [PDF]
, 2008 Toll-like receptor (TLR) signaling induces a rapid reorganization of the actin cytoskeleton in cultured mouse dendritic cells (DC), leading to enhanced antigen endocytosis and a concomitant loss of filamentous actin–rich podosomes.
Chan, Kui Ming +6 more
core +5 more sources
Lebein, a Snake Venom Disintegrin, Induces Apoptosis in Human Melanoma Cells
Toxins, 2016 Melanoma, the most threatening form of skin cancer, has a very poor prognosis and is characterized by its very invasive and chemoresistant properties.
Manel B. Hammouda +8 more
doaj +1 more source
Immuno Magnetic Thermosensitive Liposomes For Cancer Therapy [PDF]
, 2019 The present work describes the encapsulation of the drug doxorubicin (DOX) in immuno paramagnetic thermosensitive liposomes. DOX is the most common chemotherapeutic agent for the treatment of a variety of carcinomas.
Alawak, Mohamad
core +1 more source
The role of proteases in pathologies of the synovial joint [PDF]
, 2008 Synovial (diarthrodial) joints are employed within the body to provide skeletal mobility and have a characteristic structure adapted to provide a smooth almost frictionless surface for articulation.
Buttle, D, Jones, GC, Riley, GP
core +1 more source
Integrins, cancer and snake toxins (mini-review)
Journal of Venomous Animals and Toxins including Tropical Diseases, 2005 Integrins encompass a family of transmembrane heterodimeric proteins of adhesion that maintain cells attached to other cells and to the extracellular matrix (ECM).
G. Rádis-Baptista
doaj +1 more source
Removal of extracellular human amyloid beta aggregates by extracellular proteases in C. elegans
eLife, 2023 The amyloid beta (Aβ) plaques found in Alzheimer’s disease (AD) patients’ brains contain collagens and are embedded extracellularly. Several collagens have been proposed to influence Aβ aggregate formation, yet their role in clearance is unknown.
Elisabeth Jongsma +3 more
doaj +1 more source
NKG2D and its ligands: one for all, all for one [PDF]
, 2018 The activating receptor NKG2D is peculiar in its capability to bind to numerous and highly diversified MHC class I-like self-molecules. These ligands are poorly expressed on normal cells but can be induced on damaged, transformed or infected cells, with ...
Cerboni, Cristina +7 more
core +2 more sources
ToxinsViperid snake venoms are notably abundant in metalloproteinases (proteins) (SVMPs), which are primarily responsible for inducing hemorrhage and disrupting the hemostatic process and tissue integrity in envenomed victims.
Pedro Henrique de Caires Schluga +10 more
doaj +1 more source
The Anti-Cancer Potency and Mechanism of a Novel Tumor-Activated Fused Toxin, DLM
Toxins, 2015 Melittin, which acts as a membrane-disrupting lytic peptide, is not only cytotoxic to tumors, but also vital to normal cells. Melittin had low toxicity when coupled with target peptides.
Dejun Sun +5 more
doaj +1 more source