Results 41 to 50 of about 78,401 (264)

Disintegrins from the venom of Vipera ammodytes ammodytes efficiently inhibit migration of breast cancer cells

Acta Chimica Slovenica, 2017
Integrins are plasma membrane proteins, dysfunction frequently result in cancer pathology, so they represent important targets of anti-tumor therapy. Snake venoms are known source of disintegrins (Dis), proteins that specifically bind integrins and thus ...
Zorica Latinović, Adrijana Leonardi, Toni Petan, Margareta Žlajpah, Igor Križaj   +4 more
doaj   +1 more source

Integrin α3/α6 and αV are implicated in ADAM15-activated FAK and EGFR signalling pathway individually and promote non-small-cell lung cancer progression

Cell Death and Disease, 2022
Disintegrin-metalloproteinase 15(ADAM15), a member of disintegrin metalloproteinases (ADAMs), plays important roles in various cancer types. However, the underlying ADAM15 functioning in lung cancer is still unclear.
Jieqi Zhou, Anqi Wang, Tingting Cai, Yue Li, Wenwen Du, Yang Zhang, Ruochen Zhang, Weijie Zhang, Jianjie Zhu, Yuanyuan Zeng, Jian-an Huang, Zeyi Liu   +11 more
doaj   +1 more source

Levels of von Willebrand factor antigen and von Willebrand factor cleaving protease (ADAMTS13) activity predict clinical events in chronic heart failure. [PDF]

, 2009
Decreased activity of ADAMTS13, the von Willebrand factor (VWF) cleaving protease, was recently reported in cardiovascular diseases and in hepatic failure.
Borgulya, Gábor, Cervenak, László, Förhécz, Zsolt, Gombos, Tímea, Hársfalvi, Jolán, Jánoskuti, Lívia, Kunde, Jan, Makó, Veronika, Papassotiriou, Jana, Pozsonyi, Zoltán, Prohászka, Zoltán   +10 more
core   +1 more source

A Disintegrin and Metalloprotease (ADAM): Historical Overview of Their Functions

Toxins, 2016
Since the discovery of the first disintegrin protein from snake venom and the following identification of a mammalian membrane-anchored metalloprotease-disintegrin implicated in fertilization, almost three decades of studies have identified additional ...
Nives Giebeler, Paola Zigrino
doaj   +1 more source

A Disintegrin and Metalloproteinase—Control Elements in Infectious Diseases

Frontiers in Cardiovascular Medicine, 2020
Despite recent advances in treatment strategies, infectious diseases are still under the leading causes of death worldwide. Although the activation of the inflammatory cascade is one prerequisite of defense, persistent and exuberant immune response ...
Ahmad Aljohmani, Daniela Yildiz
doaj   +1 more source

Differential expression of ADAMTS -1, -4, -5 and TIMP -3 in rat spinal cord at different stages of acute experimental autoimmune encephalomyelitis [PDF]

, 2005
Experimental autoimmune encephalomyelitis (EAE) is an animal model of inflammatory demyelination, a pathological event common to multiple sclerosis (MS). During CNS inflammation there are alterations in the extracellular matrix (ECM).
A.K. Cross, Abbaszzade, Asher, Bandtlow, Barrett, Behi, Brew, Cal, Collins-Racie, D.J. Buttle, G. Haddock, Hartung, Hashimoto, Hill, Inatani, J. Plumb, J. Surr, Jaworski, Kashiwagi, Kashiwagi, Krekoski, Kuno, Kuno, Kurazono, Langton, Lindberg, Lo, Lukes, M.N. Woodroofe, Matthews, Muir, Novak, Novak, Ohgoh, Pangalos, Porter, R.A.D. Bunning, Rosenberg, Sandy, Sasaki, Satoh, Sobel, Somerville, Tang, Teesalu, Toft-Hansen, Vankemmelbeke, Vankemmelbeke, Vazquez, Yamaguchi, Yu, Yuan, Zuo   +52 more
core   +1 more source

Alternagin-C (ALT-C), a Disintegrin-Like Cys-Rich Protein Isolated from the Venom of the Snake Rhinocerophis alternatus, Stimulates Angiogenesis and Antioxidant Defenses in the Liver of Freshwater Fish, Hoplias malabaricus

Toxins, 2017
Alternagin-C (ALT-C) is a disintegrin-like protein isolated from Rhinocerophis alternatus snake venom, which induces endothelial cell proliferation and angiogenesis.
Diana Amaral Monteiro, Heloisa Sobreiro Selistre-de-Araújo, Driele Tavares, Marisa Narciso Fernandes, Ana Lúcia Kalinin, Francisco Tadeu Rantin   +5 more
doaj   +1 more source

CXCL16 and oxLDL are induced in the onset of diabetic nephropathy [PDF]

, 2009
Diabetic nephropathy (DN) is a major cause of end-stage renal failure worldwide. Oxidative stress has been reported to be a major culprit of the disease and increased oxidized low density lipoprotein (oxLDL) immune complexes were found in patients with ...
Abdel-Aziz, Abdel-Aziz H., Abdel-Bakky, Mohamed Sadek, Amann, Kerstin Ute, Beckmann, Janet, Doberstein, Kai, Doller, Anke, El Sayed, El Sayed M., Gutwein, Paul, Kämpfer-Kolb, Nicole, Pfeilschifter, Josef Martin, Schramme, Anja, Schäfer, Liliana   +11 more
core   +1 more source

Bioinformatics analysis of structure and function of Lebestatine isolated from Macrovipera venom [PDF]

Journal of Advanced Biomedical Sciences, 2017
Background & Objective: Lebestatin is a new member of disintegrin family. This single-chain poly peptide comprises 107 amino acids isolated from Macrovipera venom.
Maryam Rabiee, Hossein Sazgar, Farzaneh Mohammadi Farsani   +2 more
doaj  

ALT-C, a disintegrin-like Cys-rich protein from Bothrops alternatus, increases skeletal myoblast viability

Journal of Venomous Animals and Toxins including Tropical Diseases, 2009
ALT-C, an ECD motif (glutamic acid, cysteine, aspartic acid) disintegrin from Bothrops alternatus snake venom, induces α2β1 integrin-mediated signaling and neutrophil chemotaxis.
RA Mesquita-Ferrari, CK de Moraes, KC Micocci, HS Selistre-de-Araújo   +3 more
doaj   +1 more source