Results 41 to 50 of about 51,218 (319)

Intracellular Processing of Metalloprotease Disintegrin ADAM12 [PDF]

Journal of Biological Chemistry, 2002
ADAM12 has been implicated in cell-cell interactions in myogenesis and cancer, but the structure of the mature form of ADAM12 is not known, and its localization on the cell surface has been questioned. In this report, we show that full-length ADAM12 is N-glycosylated in the endoplasmic reticulum (ER) and proteolytically processed in the trans-Golgi ...
Zhefeng Zhao, Qing Kang, Yi Cao, Anna Zolkiewska   +3 more
openaire   +3 more sources

Disintegrin targeting of an αvβ3 integrin-over-expressing high-metastatic human osteosarcoma with echistatin inhibits cell proliferation, migration, invasion and adhesion in vitro. [PDF]

, 2016
The in vitro efficacy of the disintegrin echistatin was tested on a high-metastatic variant of 143B human osteosarcoma, 143B-LM4, which over-expresses αvβ3 integrin. Echistatin is an RGD cyclic peptide and an antagonist of αvβ3 integrin.
Bouvet, Michael, Hoffman, Robert M, Kanaya, Fuminori, Kimura, Hiroaki, Kiyuna, Tasuku, Sugimoto, Naotoshi, Tome, Yasunori, Tsuchiya, Hiroyuki   +7 more
core   +4 more sources

Macrophage-released ADAMTS1 promotes muscle stem cell activation. [PDF]

, 2017
Coordinated activation of muscle stem cells (known as satellite cells) is critical for postnatal muscle growth and regeneration. The muscle stem cell niche is central for regulating the activation state of satellite cells, but the specific extracellular ...
Aggarwal, Abhishek, Cho, Joonseok, Du, Hongqing, Feldman, Brian J, Mueller, Alisa A, Rando, Thomas A, Shih, Chung-Hsuan, Wosczyna, Michael N   +7 more
core   +2 more sources

ADAM15 modulates outside-in signalling in chondrocyte–matrix interactions [PDF]

, 2008
ADAM15 belongs to a family of transmembrane multi-domain proteins implicated in proteolysis, cell–cell and cell–matrix interactions in various disease conditions.
Burkhardt, Harald, Böhm, Beate B., Schirner, Andrea   +2 more
core   +1 more source

Integrin α3/α6 and αV are implicated in ADAM15-activated FAK and EGFR signalling pathway individually and promote non-small-cell lung cancer progression

Cell Death and Disease, 2022
Disintegrin-metalloproteinase 15(ADAM15), a member of disintegrin metalloproteinases (ADAMs), plays important roles in various cancer types. However, the underlying ADAM15 functioning in lung cancer is still unclear.
Jieqi Zhou, Anqi Wang, Tingting Cai, Yue Li, Wenwen Du, Yang Zhang, Ruochen Zhang, Weijie Zhang, Jianjie Zhu, Yuanyuan Zeng, Jian-an Huang, Zeyi Liu   +11 more
doaj   +1 more source

Disintegrins from the venom of Vipera ammodytes ammodytes efficiently inhibit migration of breast cancer cells

Acta Chimica Slovenica, 2017
Integrins are plasma membrane proteins, dysfunction frequently result in cancer pathology, so they represent important targets of anti-tumor therapy. Snake venoms are known source of disintegrins (Dis), proteins that specifically bind integrins and thus ...
Zorica Latinović, Adrijana Leonardi, Toni Petan, Margareta Žlajpah, Igor Križaj   +4 more
doaj   +1 more source

Regulation of A disintegrin and metalloproteinase (ADAM) family sheddases ADAM10 and ADAM17: The emerging role of tetraspanins and rhomboids

Platelets, 2016
A disintegrin and metalloprotease (ADAM) 10 and ADAM17 are ubiquitous transmembrane “molecular scissors” which proteolytically cleave, or shed, the extracellular regions of other transmembrane proteins.
A. Matthews, Peter J. Noy, J. Reyat, M. Tomlinson   +3 more
semanticscholar   +1 more source

The Regulation of Aggrecanase ADAMTS-4 Expression in Human Achilles Tendon and tendon-Derived Cells [PDF]

, 2008
Several members of the ADAMTS (A Disintegrin And Metalloproteinase with ThromboSpondin motifs) family have been identified as aggrecanases, whose substrates include versican, the principal large proteoglycan in the tendon extracellular matrix.
Corps, Anthony N., Curry, Valerie A., Harrall, Rebecca L., Hazleman, Brian L., Jones, Gavin C., Riley, Graham P.   +5 more
core   +2 more sources

Integrins, cancer and snake toxins (mini-review)

Journal of Venomous Animals and Toxins including Tropical Diseases, 2005
Integrins encompass a family of transmembrane heterodimeric proteins of adhesion that maintain cells attached to other cells and to the extracellular matrix (ECM).
G. Rádis-Baptista
doaj   +1 more source

Gene expression and matrix turnover in overused and damaged tendons [PDF]

, 2005
Chronic, painful conditions affecting tendons, frequently known as tendinopathy, are very common types of sporting injury. The tendon extracellular matrix is substantially altered in tendinopathy, and these changes are thought to precede and underlie the
Abbaszade I, Akeson WH, Alfredson H, Amiel D, Archambault J, Astrom M, Bank RA, Banyard J, Benjamin M., Berenson MC, Boot-Handford RP, Brown PD., Cal S, Caterson B, Cawston TE, Cawston TE., Clark IM, Colige A, Colige A, Collins-Racie LA, Corps AN, Corps AN, Curwin SL, Dalton S, Dickinson SC, Eriksen HA, Everts V, Fernandes RJ, Fitzgerald J, Flannery CR, G. P. Riley, Gao G, Gelberman RH, Gillard GC, Gotoh M, Hannafin JA., Hardingham TE, Hashimoto T, Heinemeier K, Ireland D, Jarvinen M, Jozsa L, Jozsa L, Kannus P, Kannus P., Kannus P., Kashiwagi M, Kashiwagi M, Kaushal GP, Kjaer M, Koch M, Koch M, Koshy PJ, Koskinen SO, Kuno K, Langberg H, Langberg H, Langberg H, Leadbetter WB., Lehto M, McCawley LJ, McNeilly CM, Murphy G, Myllyharju J, Nagase H., Pace JM, Patterson-Kane JC, Pierfitte C, Rees SG, Riley G., Riley GP, Riley GP, Riley GP, Riley GP, Riley GP, Riley GP., Samiric T, Samiric T, Sandy JD, Sandy JD, Sandy JD, Sato K, Smith RK, Smith RK, Somerville RP, Tipton CM, Tortorella MD, Tortorella MD, Tsuzaki M, Vankemmelbeke MN, Vogel KG, Waggett AD, Wang P, Woo SLY, Woo SLY, Woo SLY, Yasuda K, Yoshihara Y   +97 more
core   +1 more source