Results 131 to 140 of about 1,487 (157)

Metal-organic framework nanoparticles induced non-apoptotic cell death: Construction, mechanisms, and cancer therapy. [PDF]

Mater Today Bio
Ma S, Wei Y, Li Y, Dong W, Mu H, Zhou S, Zhang X, Chen L, Yang Y, Yu S.   +9 more
europepmc   +1 more source

Intratumoral disulfidptosis heterogeneity in triple-negative breast cancer, a multiomics integration analysis. [PDF]

Transl Cancer Res
Dong ZX, Ou-Yang Y, Fang L, Song XQ.
europepmc   +1 more source

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Pan-cancer genetic analysis of disulfidptosis-related gene set

Cancer Genetics, 2023
A recent study has identified a novel programmed cell death pathway, termed disulfidptosis, which is based on disulfide proteins. This discovery provides new insight into the mechanisms of cell death and may have implications for therapeutic strategies targeting cell death pathways.
Hengrui Liu
exaly   +3 more sources

Disulfidptosis: disulfide stress–induced cell death

Trends in Cell Biology
The cystine transporter solute carrier family 7 member 11 (SLC7A11) (also known as xCT) promotes glutathione synthesis and counters oxidative stress-induced cell death, including ferroptosis, by importing cystine. Also, SLC7A11 plays a crucial role in tumor development.
Xiaoguang Liu, Boyi Gan
exaly   +3 more sources

Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis

Nature Cell Biology, 2023
SLC7A11-mediated cystine uptake suppresses ferroptosis yet promotes cell death under glucose starvation; the nature of the latter cell death remains unknown. Here we show that aberrant accumulation of intracellular disulfides in SLC7A11high cells under glucose starvation induces a previously uncharacterized form of cell death distinct from apoptosis ...
Xiaoguang Liu, Litong Nie, Yilei Zhang, Yuelong Yan, Chao Wang, Medina Colic, Kellen Olszewski, Amber Horbath, Xiong Chen, Guang Lei, Chao Mao, Shiqi Wu, Li Zhuang, Masha V. Poyurovsky, M. James You, Traver Hart, Daniel D. Billadeau, Junjie Chen, Boyi Gan   +18 more
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Disulfidptosis

Current Biology
Li et al. introduce disulfidptosis, a recently identified form of regulated cell death triggered by excessive disulfide stress.
Qidong, Li, Li, Zhuang, Boyi, Gan
openaire   +2 more sources

Role of disulfidptosis in colorectal adenocarcinoma: implications for prognosis and immunity

Frontiers in Immunology
BackgroundRecent research has found a new way of cell death: disulfidptosis. Under glucose starvation, abnormal accumulation of disulfide molecules such as Cystine in Solute Carrier Family 7 Member 11 (SLC7A11) overexpression cells induced disulfide stress to trigger cell death.
Manzhao Ouyang, Jinge Xin, Lai Chunxiao   +2 more
exaly   +4 more sources

The emerging role of disulfidptosis in Alzheimer's disease

European Journal of Pharmacology
Alzheimer's disease (AD) is a chronic neurodegenerative disorder primarily characterized by Aβ deposition and tau hyperphosphorylation. Clinically, AD manifests as progressive episodic-memory loss that ultimately erodes global cognition and the ability to perform activities of daily living.
Qiong, Zhou, Nan, Zheng, Zihao, Chen, Lihua, Xie, Xinyu, Yang, Qiang, Sun, Jiantao, Lin, Baohong, Li, Li, Li   +8 more
openaire   +2 more sources

Involvement of disulfidptosis in the pathophysiology of autism spectrum disorder

Life Sciences
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder, with oxidative stress recognized as a key pathogenic mechanisms. Oxidative stress disrupts intracellular dynamic- thiol/disulfide homeostasis (DTDH), potentially leading to disulfidptosis, a newly identified cell death mechanism.
Yutong, Liu, Yaqi, Sun, Anjie, Chen, Jiaqi, Chen, Tikang, Zhu, Shuting, Wang, Wanying, Qiao, Ding, Zhou, Xirui, Zhang, Shuangshuang, Chen, Yaxin, Shi, Yuan, Yang, Jia, Wang, Lijie, Wu, Lili, Fan   +14 more
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Role of disulfidptosis in cancer: Molecular mechanisms and therapeutic opportunities

Cellular Signalling
Disulfidptosis, as a novel form of programmed cell death, is different from ferroptosis and cuproptosis. Numerous studies have shown that glucose starvation is a key characteristic of disulfidptosis. Under the condition of high expression of solute carrier family 7 member 11, the content of nicotinamide adenine dinucleotide phosphate hydrogen changes ...
Hang-Shen, Han, Meng-Yuan, Hao, Hong-Jie, Li, Yan-Ge, Li, Ti, Chu, Yan-Wen, Wang, Wei-Rong, Si, Qi-Ying, Jiang, Dong-Dong, Wu   +8 more
openaire   +2 more sources