Results 141 to 150 of about 1,487 (157)

Deciphering the rules of disulfidptosis: a genome-wide signature for identifying disulfidptosis-related genes and analyzing hepatocellular carcinoma chemotherapy sensitivities

Free Radical Biology and Medicine
Disulfidptosis, a novel form of regulated cell death (RCD), represents a promising strategy for cancer therapy. However, identifying its regulators remains a key challenge. In this study, we constructed a genome-wide disulfidptosis signature (DS) model using known regulators and large-scale human gene expression data comprising 1454 studies and 272,445
Yi Zhang, Ying Guo, Wenxi He, Yaping Zhao, Zhaode Feng, Mengjiao Shi, Xinyan Li, Liangwen Yan, Jiayi Xu, Kailing Hu, Rongrong Liu, Yinggang Zhang, Gang Wang, Hao Li, Pengfei Liu   +14 more
openaire   +2 more sources

Exploring the immune landscape of disulfidptosis in ulcerative colitis and the role of modified gegen qinlian decoction in mediating disulfidptosis to alleviate colitis in mice

Journal of Ethnopharmacology
Ulcerative colitis (UC), a recurrent inflammatory bowel disease, continues to challenge effective pharmacologic management. Disulfidptosis, a recently identified form of cell death, appears implicated in the progression of various diseases. Scientific studies have demonstrated that Modified Gegen Qinlian decoction (MGQD) alleviates UC symptoms. However,
Jinke Huang
exaly   +3 more sources

Disulfidptosis in cancer: from redox stress to therapeutic strategy

Cancer Gene Therapy
Disulfidptosis, a recently identified form of disulfide-dependent cell death, has emerged as a key regulator of cancer progression and therapy resistance. This review examines the molecular mechanisms connecting the redox balance within the tumor microenvironment (TME), outlines its crosstalk with traditional cell death pathways, and highlights its ...
Xinpei Deng, Chengyi Zhang, Jindong Xie, Binbin Tang, Xingliang Tan, Yutian Zou   +5 more
openaire   +2 more sources

Therapeutic Potential of lncRNAs in Regulating Disulfidptosis for Cancer Treatment

Pathology - Research and Practice
Non-coding RNAs (lncRNAs) play critical roles in various cellular processes, including a novel form of regulated cell death known as disulfidptosis, characterized by accumulating protein disulfide bonds and severe endoplasmic reticulum stress. This review highlights the therapeutic potential of lncRNAs in regulating disulfidptosis for cancer treatment,
, Abida, Abdulmalik S A, Altamimi, Nehmat, Ghaboura, Ashok Kumar, Balaraman, Pranchal, Rajput, Pooja, Bansal, Sushama, Rawat, Fadiyah Jadid, Alanazi, Abeer Nuwayfi, Alruwaili, Nouf Afit, Aldhafeeri, Haider, Ali, Pran Kishore, Deb   +11 more
openaire   +2 more sources

Nanomedicine strategies for disulfidptosis activation in SLC7A11-high tumors

Colloids and Surfaces B: Biointerfaces
Disulfidptosis is a recently identified form of regulated cell death (RCD) characterized by aberrant disulfide bond accumulation and cytoskeletal collapse under conditions of redox imbalance. SLC7A11-overexpressing tumors are uniquely susceptible to this pathway due to their elevated cystine uptake and dependence on glucose-driven NADPH production for ...
Zhanzheng Ye, Yinsha Yao, Yitianhe Xu, Jinyao Ye, Qing Yao, Longfa Kou, Ruijie Chen   +6 more
openaire   +2 more sources

Correlation of disulfidptosis and periodontitis: New insights and clinical significance

Archives of Oral Biology
This study aims to investigate and predict the therapeutic agents associated with disulfidptosis in periodontitis.The dataset GSE10334 was downloaded from the Gene Expression Omnibus (GEO) database and used to train a least absolute shrinkage and selection operator (LASSO) regression and support vector machine recursive feature elimination (SVM-RFE ...
Yixin, Fan, Wantong, Liu, Le, Qi, Qi, Zhao, Sining, Li, He, Zou, Chen, Kong, Zhiwei, Li, Jiwei, Ren, Zhihui, Liu, Bowei, Wang   +10 more
openaire   +2 more sources

Disulfidptosis classification of hepatocellular carcinoma reveals correlation with clinical prognosis and immune profile

International Immunopharmacology, 2023
Wenyong Wu
exaly  

Identification of disulfidptosis related subtypes, characterization of tumor microenvironment infiltration, and development of DRG prognostic prediction model in RCC, in which MSH3 is a key gene during disulfidptosis

Frontiers in Immunology, 2023
Li Yanze, Liu Xiuheng
exaly  

Disulfidptosis meets antitumour immunity

Nature Cell Biology
Qidong Li, Boyi Gan
openaire   +2 more sources

Identification of a disulfidptosis-related genes signature for prognostic implication in lung adenocarcinoma

Computers in Biology and Medicine, 2023
Jiarui Wu, Leiming You, Jiaqi Huang
exaly