Results 161 to 170 of about 2,022 (185)

Disulfidptosis: A new type of cell death

Apoptosis: an International Journal on Programmed Cell Death
AbstractDisulfidptosis is a novel form of cell death that is distinguishable from established programmed cell death pathways such as apoptosis, pyroptosis, autophagy, ferroptosis, and oxeiptosis. This process is characterized by the rapid depletion of nicotinamide adenine dinucleotide phosphate (NADPH) in cells and high expression of solute carrier ...
Bei Yang
exaly   +3 more sources

Some of the next articles are maybe not open access.

Related searches:

Disulfidptosis: disulfide stress–induced cell death

Trends in Cell Biology
The cystine transporter solute carrier family 7 member 11 (SLC7A11) (also known as xCT) promotes glutathione synthesis and counters oxidative stress-induced cell death, including ferroptosis, by importing cystine. Also, SLC7A11 plays a crucial role in tumor development.
Xiaoguang Liu, Boyi Gan, Li Zhuang
exaly   +3 more sources

Identification of disulfidptosis related subtypes, characterization of tumor microenvironment infiltration, and development of DRG prognostic prediction model in RCC, in which MSH3 is a key gene during disulfidptosis [PDF]

Frontiers in Immunology, 2023
Disulfidptosis is a newly discovered mode of cell death induced by disulfide stress. However, the prognostic value of disulfidptosis-related genes (DRGs) in renal cell carcinoma (RCC) remains to be further elucidated.
Yang Du, Zhiwei Yan
exaly   +2 more sources

Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis

Nature Cell Biology, 2023
SLC7A11-mediated cystine uptake suppresses ferroptosis yet promotes cell death under glucose starvation; the nature of the latter cell death remains unknown. Here we show that aberrant accumulation of intracellular disulfides in SLC7A11high cells under glucose starvation induces a previously uncharacterized form of cell death distinct from apoptosis ...
Xiaoguang Liu, Litong Nie, Yilei Zhang, Yuelong Yan, Chao Wang, Medina Colic, Kellen Olszewski, Amber Horbath, Xiong Chen, Guang Lei, Chao Mao, Shiqi Wu, Li Zhuang, Masha V. Poyurovsky, M. James You, Traver Hart, Daniel D. Billadeau, Junjie Chen, Boyi Gan   +18 more
openaire   +2 more sources

Disulfidptosis

Current Biology
Li et al. introduce disulfidptosis, a recently identified form of regulated cell death triggered by excessive disulfide stress.
Qidong, Li, Li, Zhuang, Boyi, Gan
openaire   +2 more sources

The emerging role of disulfidptosis in Alzheimer's disease

European Journal of Pharmacology
Alzheimer's disease (AD) is a chronic neurodegenerative disorder primarily characterized by Aβ deposition and tau hyperphosphorylation. Clinically, AD manifests as progressive episodic-memory loss that ultimately erodes global cognition and the ability to perform activities of daily living.
Qiong, Zhou, Nan, Zheng, Zihao, Chen, Lihua, Xie, Xinyu, Yang, Qiang, Sun, Jiantao, Lin, Baohong, Li, Li, Li   +8 more
openaire   +2 more sources

Involvement of disulfidptosis in the pathophysiology of autism spectrum disorder

Life Sciences
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder, with oxidative stress recognized as a key pathogenic mechanisms. Oxidative stress disrupts intracellular dynamic- thiol/disulfide homeostasis (DTDH), potentially leading to disulfidptosis, a newly identified cell death mechanism.
Yutong, Liu, Yaqi, Sun, Anjie, Chen, Jiaqi, Chen, Tikang, Zhu, Shuting, Wang, Wanying, Qiao, Ding, Zhou, Xirui, Zhang, Shuangshuang, Chen, Yaxin, Shi, Yuan, Yang, Jia, Wang, Lijie, Wu, Lili, Fan   +14 more
openaire   +2 more sources

Therapeutic Potential of lncRNAs in Regulating Disulfidptosis for Cancer Treatment

Pathology - Research and Practice
Non-coding RNAs (lncRNAs) play critical roles in various cellular processes, including a novel form of regulated cell death known as disulfidptosis, characterized by accumulating protein disulfide bonds and severe endoplasmic reticulum stress. This review highlights the therapeutic potential of lncRNAs in regulating disulfidptosis for cancer treatment,
, Abida, Abdulmalik S A, Altamimi, Nehmat, Ghaboura, Ashok Kumar, Balaraman, Pranchal, Rajput, Pooja, Bansal, Sushama, Rawat, Fadiyah Jadid, Alanazi, Abeer Nuwayfi, Alruwaili, Nouf Afit, Aldhafeeri, Haider, Ali, Pran Kishore, Deb   +11 more
openaire   +2 more sources

Deciphering the rules of disulfidptosis: a genome-wide signature for identifying disulfidptosis-related genes and analyzing hepatocellular carcinoma chemotherapy sensitivities

Free Radical Biology and Medicine
Disulfidptosis, a novel form of regulated cell death (RCD), represents a promising strategy for cancer therapy. However, identifying its regulators remains a key challenge. In this study, we constructed a genome-wide disulfidptosis signature (DS) model using known regulators and large-scale human gene expression data comprising 1454 studies and 272,445
Yi Zhang, Ying Guo, Wenxi He, Yaping Zhao, Zhaode Feng, Mengjiao Shi, Xinyan Li, Liangwen Yan, Jiayi Xu, Kailing Hu, Rongrong Liu, Yinggang Zhang, Gang Wang, Hao Li, Pengfei Liu   +14 more
openaire   +2 more sources

Role of disulfidptosis in cancer: Molecular mechanisms and therapeutic opportunities

Cellular Signalling
Disulfidptosis, as a novel form of programmed cell death, is different from ferroptosis and cuproptosis. Numerous studies have shown that glucose starvation is a key characteristic of disulfidptosis. Under the condition of high expression of solute carrier family 7 member 11, the content of nicotinamide adenine dinucleotide phosphate hydrogen changes ...
Hang-Shen, Han, Meng-Yuan, Hao, Hong-Jie, Li, Yan-Ge, Li, Ti, Chu, Yan-Wen, Wang, Wei-Rong, Si, Qi-Ying, Jiang, Dong-Dong, Wu   +8 more
openaire   +2 more sources