Results 71 to 80 of about 31,432 (120)

Chronic Trypanosoma cruzi infection potentiates adipose tissue macrophage polarization toward an anti-inflammatory M2 phenotype and contributes to diabetes progression in a diet-induced obesity model [PDF]

, 2016
Chronic obesity and Chagas disease (caused by the protozoan Trypanosoma cruzi) represent serious public health concerns. The interrelation between parasite infection, adipose tissue, immune system and metabolism in an obesogenic context, has not been ...
Andrada, Marta Cecilia, Aoki, Maria del Pilar, Cabalén, María Eugenia, Cabral, Maria Fernanda, Cano, Roxana Carolina, Gea, Susana, Onofrio, Luisina Inés, Ponce, Nicolás Eric, Sanmarco, Liliana Maria   +8 more
core   +4 more sources

Lactylation: From Homeostasis to Pathological Implications and Therapeutic Strategies

MedComm, Volume 6, Issue 6, June 2025.
Lactylation, a novel post‐translational modification derived from lactate metabolism, plays a critical role in cellular homeostasis and disease pathogenesis. Under physiological conditions, lactylation regulates gene expression, immune responses, and metabolic adaptation. However, dysregulated lactylation is implicated in various pathological processes,
Xi Chen, Yixiao Yuan, Fan Zhou, Lihua Li, Jun Pu, Yong Zeng, Xiulin Jiang   +6 more
wiley   +1 more source

Molecular characterization of a synthetic neutralizing antibody targeting p67 of Theileria parva

Protein Science, Volume 34, Issue 6, June 2025.
Abstract The Theileria parva sporozoite surface antigen p67 is a target of the bovine humoral immune response that generates antibodies capable of providing protection against subsequent infection. As a result, p67 has been the subject of efforts aimed at the development of an anti‐sporozoite subunit vaccine.
Shane Miersch, Alex U. Singer, Chao Chen, Fred Fellouse, Anupriya Gopalsamy, Luciano Silva e Costa, Anna Lacasta, Hannah Chege, Naomi Chege, Vishvanath Nene, Sachdev S. Sidhu   +10 more
wiley   +1 more source

Evolution and diversity of secretome genes in the apicomplexan parasite Theileria annulata [PDF]

, 2010
<b>BACKGROUND</b>: Little is known about how apicomplexan parasites have evolved to infect different host species and cell types. Theileria annulata and Theileria parva invade and transform bovine leukocytes but each species favours a ...
Baird, M., Karagenç, T., Shiels, B.R., Tait, A., Weir, W.   +4 more
core   +4 more sources

Metabarcoding Unveils the Diversity and Dynamics of In Situ Diet and Symbionts Associated With Copepods in Chinese Coastal Waters

Diversity and Distributions, Volume 31, Issue 6, June 2025.
ABSTRACT Aim Copepods are the key secondary producers in marine ecosystems, yet their in situ diet and symbionts remain underexplored due to technical challenges, limiting our understanding of their population dynamics and ecological functions. Using DNA metabarcoding, we jointly characterised the natural diet and symbionts of copepods across Chinese ...
Yu Zang, Yunyun Zhuang, Jingyi Zhu, Tianying Chen, Jianwei Chen, Zeqi Zheng, Hongju Chen, Huan Zhang, Senjie Lin, Guangxing Liu   +9 more
wiley   +1 more source

Adaptation of Marine Heterotrophic Protists to Long‐Term Warming Selection

Global Change Biology, Volume 31, Issue 6, June 2025.
Our study unraveled profitable adaptations of marine protozoa to long‐term warming. The optimal temperature, maximum growth rates, cell homeostasis, and cell size significantly increased after warming adaptation, suggesting a resilient future for this functional group.
Mengwen Pang, Zuyuan Gao, Lingfeng Huang, Chuk Man Chan, Xiaodong Zhang, Ruilin Su, Ke Pan, Hongbin Liu   +7 more
wiley   +1 more source

Potential Zoonotic Infections Transmitted by Free‐Ranging Macaques in Human–Monkey Conflict Areas in Thailand

Zoonoses and Public Health, Volume 72, Issue 4, Page 349-358, June 2025.
ABSTRACT Introduction Nonhuman primates (NHPs) can transmit zoonotic diseases to humans because of their close genetic relationship, facilitating the cross‐species transmission of certain pathogens. In Thailand, Macaca is the most common NHP genus and their inhabits area are in close proximity of human, particularly in urban and suburban areas, where ...
Sarin Suwanpakdee, Benjaporn Bhusri, Aeknarin Saechin, Chalisa Mongkolphan, Siriporn Tangsudjai, Parut Suksai, Supakarn Kaewchot, Rattana Sariwongchan, Piya Sereerak, Ladawan Sariya   +9 more
wiley   +1 more source

Introducing the concept of biocatalysis in the classroom: The conversion of cholesterol to provitamin D 3 [PDF]

, 2016
Biocatalysis is a fundamental concept in biotechnology. The topic integrates knowledge of several disciplines; therefore, it was included in the course “design and optimization of biological systems” which is offered in the biochemistry curricula.
De Luca, Belén M., Gonzalez, Rodrigo Horacio, Nudel, Berta Clara, Nusblat, Alejandro David   +3 more
core   +1 more source

Profiling Serine Hydrolases in the Leishmania Host–Pathogen Interactome Using Cell‐Permeable Activity‐Based Fluorophosphonate Probes

ChemBioChem, Volume 26, Issue 10, May 27, 2025.
Leishmaniasis poses a global health challenge with limited treatment options and rising drug resistance. Activity‐based protein profiling using fluorophosphonate probes is employed to profile serine hydrolases, key virulence factors in Leishmania mexicana.
Jaime A. Isern, Exequiel O. J. Porta, Karunakaran Kalesh, Zisis Koutsogiannis, Davide Cazzola, Ehmke Pohl, Paul W. Denny, Patrick G. Steel   +7 more
wiley   +1 more source

Kinetoplastids:related protozoan pathogens, different diseases [PDF]

, 2008
Kinetoplastids are a group of flagellated protozoans that include the species Trypanosoma and Leishmania, which are human pathogens with devastating health and economic effects. The sequencing of the genomes of some of these species has highlighted their
Agranoff, Alan Fairlamb, Albrecht, Ambroise-Thomas, Andrade, Armijos, Atwood, Avila, Balana-Fouce, Benchimol Barbosa, Bern, Berriman, Bhattacharya, Bhattacharya, Bisser, Brun, Burleigh, Burns, Burri, Campos-Neto, Castro, Chava, Cohen, Coler, Coler, Coler, Combs, Croft, da Costa, de Castro, De Luca, de Macedo, Deborggraeve, Deng, Denkers, Dias, Doyle, Eastman, El Kouni, El-Sayed, Engel, Engers, Enserink, Ferguson, Frearson, Genaro, Ghalib, Ghalib, Gorczynski, Grazia, Grevelink, Guler, Gurtler, Gurtler, Gurtler, Gürtler, Hammarton, Hawn, Heby, Hopkins, Houghton, Jim McKerrow, Jones, Ken Stuart, Kgori, Khalil, Khalil, Krauth-Siegel, Kroeger, Kropf, Launois, Lee, Lejon, Lohoff, Magnus, Marsden, Marth, Martin, Mayrink, Mazurek, McConville, Molina, Nare, Nwaka, Nylen, Olliaro, Opperdoes, Ouellette, Panethymitaki, Picollo, Pirard, Radwanska, Radwanska, Ramesh, Reed, Reed, Reiner, Reithinger, Reithinger, Renslo, Reto Brun, Ricardo E. Gürtler, Rick Tarleton, Sadeghian, Scharton-Kersten, Schmid, Schnaufer, Simon Croft, Skeiky, Sosa, Soto, Steve Reed, Stuart, Sundar, Sundar, Tarleton, Tarleton, Tarleton, Thakur, Torr, Urbina, Viotti, Viotti, Welburn, Werbovetz, Xong, Young, Zijlstra   +127 more
core   +3 more sources