Results 61 to 70 of about 1,287,961 (310)

Editorial: The impact of the DNA damage response on anti-tumor immunity [PDF]

, 2022
Gang Chen, Shengtao Zhou, Chaoyang Sun, Leng Han   +3 more
openalex   +1 more source

A Genetic Map of the Response to DNA Damage in Human Cells

Cell, 2019
The response to DNA damage is critical for cellular homeostasis, tumor suppression, immunity and gametogenesis. In order to provide an unbiased and global view of the DNA damage response in human cells, we undertook 28 CRISPR/Cas9 screens against 25 ...
Michele Olivieri, Michele Olivieri, Tiffany Cho, Tiffany Cho, Alejandro Álvarez-Quilón, Kejiao Li, M. Schellenberg, Michal Zimmermann, Nicole Hustedt, S. Rossi, Salomé Adam, Henrique Melo, A. Heijink, Guillermo Sastre-Moreno, N. Moatti, R. Szilard, Andrea McEwan, Alexanda K. Ling, Almudena Serrano-Benitez, T. Ubhi, Sumin Feng, J. Pawling, Irene Delgado-Sainz, Michael W. Ferguson, J. Dennis, J. Dennis, Grant W. Brown, Felipe Cortés-Ledesma, R. S. Williams, Alberto Martin, Dongyi Xu, D. Durocher, D. Durocher   +32 more
semanticscholar   +1 more source

Replication Stress, DNA Damage, Inflammatory Cytokines and Innate Immune Response

Genes, 2020
Complete and accurate DNA replication is essential to genome stability maintenance during cellular division. However, cells are routinely challenged by endogenous as well as exogenous agents that threaten DNA stability.
S. Ragu, Gabriel E. Matos-Rodrigues, B. Lopez   +2 more
semanticscholar   +1 more source

Mitochondrial fatty acid oxidation is stimulated by red light irradiation

FEBS Letters, EarlyView.
Light at different wavelengths has distinct effects on keratinocyte viability and metabolism. UVA light abrogates metabolic fluxes. Blue and green light have no effect on metabolic fluxes, while red light enhanced oxidative phosphorylation by promoting fatty acid oxidation. Keratinocytes are the primary constituents of sunlight‐exposed epidermis.
Manuel Alejandro Herrera, Camille C. Caldeira da Silva, Maiza Von Dentz, Mauricio S. Baptista, Alicia J. Kowaltowski   +4 more
wiley   +1 more source

O‐glycosylation in viruses: A sweet tango

mLife
O‐glycosylation is an ancient yet underappreciated protein posttranslational modification, on which many bacteria and viruses heavily rely to perform critical biological functions involved in numerous infectious diseases or even cancer.
Annan Ming, Jianxin Zhao, Yihan Liu, Yibo Wang, Xiaohui Wang, Jing Li, Leiliang Zhang   +6 more
doaj   +1 more source

DNA Damage Response Pathways in Dinoflagellates

Microorganisms, 2019
Dinoflagellates are a general group of phytoplankton, ubiquitous in aquatic environments. Most dinoflagellates are non-obligate autotrophs, subjected to potential physical and chemical DNA-damaging agents, including UV irradiation, in the euphotic zone ...
Chongping Li, Joseph Tin Yum Wong
doaj   +1 more source

Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage response factors

Nature Cell Biology, 2019
Damage-induced long non-coding RNAs (dilncRNA) synthesized at DNA double-strand breaks (DSBs) by RNA polymerase II are necessary for DNA-damage-response (DDR) focus formation.
Fabio Pessina, F. Giavazzi, Yandong Yin, Ubaldo Gioia, V. Vitelli, A. Galbiati, S. Barozzi, M. Garrè, A. Oldani, Andrew Flaus, R. Cerbino, D. Parazzoli, E. Rothenberg, F. d’Adda di Fagagna   +13 more
semanticscholar   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

DNA Damage Response and Oxidative Stress in Systemic Autoimmunity

International Journal of Molecular Sciences, 2019
The DNA damage response and repair (DDR/R) network, a sum of hierarchically structured signaling pathways that recognize and repair DNA damage, and the immune response to endogenous and/or exogenous threats, act synergistically to enhance cellular ...
V. Souliotis, N. Vlachogiannis, M. Pappa, A. Argyriou, Panagiotis A. Ntouros, P. Sfikakis   +5 more
semanticscholar   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source