Results 61 to 70 of about 1,846,477 (392)

MRE11-RAD50-NBS1 complex alterations and DNA damage response: implications for cancer treatment

Molecular Cancer, 2019
Genome instability is a hallmark of cancer cells and can be accelerated by defects in cellular responses to DNA damage. This feature of malignant cells opens new avenues for tumor targeted therapy. MRE11-RAD50-NBS1 complex plays a crucial role in sensing
L. Bian, Yiling Meng, Meichao Zhang, Dong Li   +3 more
semanticscholar   +1 more source

ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1

Nature Communications, 2017
ATR kinase activity is essential for slowing replication forks and preventing DNA replication in cells with DNA damage. Here the authors show that ATR inhibition leads to Cdc7 phosphorylation of GINS, leading to origin firing.
Tatiana Moiseeva, Brian Hood, Sandy Schamus, Mark J. O’Connor, Thomas P. Conrads, Christopher J. Bakkenist   +5 more
doaj   +1 more source

Tolerance to paternal genotoxic damage promotes survival during embryo development in zebrafish (Danio rerio)

Biology Open, 2018
Spermatozoa carry DNA damage that must be repaired by the oocyte machinery upon fertilization. Different strategies could be adopted by different vertebrates to face the paternal genotoxic damage.
Cristina Fernández-Díez, Silvia González-Rojo, Marta Lombó, M. Paz Herráez   +3 more
doaj   +1 more source

TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1 [PDF]

, 2012
The abortive activity of topoisomerases can result in clastogenic and/or lethal DNA damage in which the topoisomerase is covalently linked to the 3'- or 5'-terminus of a DNA strand break. This type of DNA damage is implicated in chromosome translocations
Abhishek Sharma, Barthelmes, Danny Huylebroeck, Davies, Davies, El-Khamisy, El-Khamisy, El-Khamisy, El-Khamisy, Esguerra, Giovanella, Hirano, Hudson, Interthal, Interthal, Junko Murai, Katyal, Keith W. Caldecott, Ledesma, Liesbeth Vermeire, Lieve Umans, Limei Ju, Murai, Nitiss, Pommier, Pommier, Pype, Sherif F. El-Khamisy, Shunichi Takeda, Takashima, Varady, Vilotti, Yang, Yves Pommier, Zeng, Zhihong Zeng, Zhou   +36 more
core   +1 more source

Cerebrospinal Fluid Liquid Biopsy Enables Targeted Therapy Without Tissue Diagnosis in Pediatric Low‐Grade Gliomas With BRAF V600E Mutation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We present two pediatric cases of pediatric low‐grade gliomas (PLGG) with BRAF V600E mutations diagnosed and monitored using cerebrospinal fluid (CSF) liquid biopsy analyzed via digital droplet PCR (ddPCR), without tissue biopsy. Both patients were treated with dabrafenib and trametinib and monitored through clinical assessments, magnetic ...
Hannah Sultan, Damien Faury, Alexander G. Weil, Harrison J. Westwick, Nada Jabado, Sébastien Perreault   +5 more
wiley   +1 more source

A sophisticated mechanism governs Pol ζ activity in response to replication stress

Nature Communications
DNA polymerase ζ (Pol ζ) plays an essential role in replicating damaged DNA templates but contributes to mutagenesis due to its low fidelity. Therefore, ensuring tight control of Pol ζ’s activity is critical for continuous and accurate DNA replication ...
Chun Li, Shuchen Fan, Pan Li, Yuzhen Bai, Ye Wang, Yueyun Cui, Mengdi Li, Ruru Wang, Yuan Shao, Yingying Wang, Shuo Zheng, Rong Wang, Lijun Gao, Miaomiao Li, Yuanyuan Zheng, Fengting Wang, Sihang Gao, Shiguo Feng, Jianing Wang, Xinqi Qu, Xialu Li   +20 more
doaj   +1 more source

Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed.
Molly Mack, A. Carolina Tufino, Mohd Azrin Jamalruddin, Sreya Dey, Yinghong Pan, Elina Mukherjee, Jessica D. Daley, Julia Meade, Mahmoud Aarabi, Lisa Maurer, James Cooper, Kara A. Bernstein, Kelly M. Bailey   +12 more
wiley   +1 more source

IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response

Science Translational Medicine, 2019
Mutant IDH1 coexpressed with inactivating TP53 and ATRX mutations in glioma enhances DNA repair, causing resistance to genotoxic therapies. Linking glioma metabolism and DNA repair Mutations in isocitrate dehydrogenase 1 (IDH1) are frequently found in ...
Felipe J. Núñez, Flor M. Mendez, Padma Kadiyala, Mahmoud S. Alghamri, M. G. Savelieff, M. Garcia-Fabiani, Santiago Haase, C. Koschmann, Anda-Alexandra Calinescu, Neha Kamran, Meghna Saxena, Rohin Patel, S. Carney, Marissa Z. Guo, Marta B. Edwards, M. Ljungman, Tingting Qin, M. Sartor, R. Tagett, S. Venneti, J. Brosnan-Cashman, A. Meeker, V. Gorbunova, Lili Zhao, Daniel M. Kremer, Li Zhang, C. Lyssiotis, L. Jones, C. Herting, J. Ross, D. Hambardzumyan, S. Hervey-Jumper, M. Figueroa, P. Lowenstein, M. Castro   +34 more
semanticscholar   +1 more source

DNA Damage Response (DDR) and DNA Repair

International Journal of Molecular Sciences, 2022
The first aim of cell division is to pass the genetic material, intact and unchanged, to the next generation [...]
openaire   +3 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source