Results 41 to 50 of about 151,241 (263)

Reconfiguration of DNA methylation in aging

Mechanisms of Ageing and Development, 2015
A complex interplay between multiple biological effects shapes the aging process. The advent of genome-wide quantitative approaches in the epigenetic field has highlighted the effective impact of epigenetic deregulation, particularly of DNA methylation, on aging. Age-associated alterations in DNA methylation are commonly grouped in the phenomenon known
ZAMPIERI, Michele, CICCARONE, FABIO, CALABRESE, ROBERTA, Claudio Franceschi, Alexander Bürkle, CAIAFA, Paola   +5 more
openaire   +4 more sources

Age-associated DNA methylation changes in Xenopus frogs

Epigenetics, 2023
Age-associated changes in DNA methylation have been characterized across various animals, but not yet in amphibians, which are of particular interest because they include widely studied model organisms.
Marco Morselli, Ronan Bennett, Nikko-Ideen Shaidani, Marko Horb, Leonid Peshkin, Matteo Pellegrini   +5 more
doaj   +1 more source

DNA methylation and cognitive aging

Oncotarget, 2015
With ever-increasing elder population, the high incidence of age-related diseases such as neurodegenerative disorders has turned out to be a huge public concern. Especially the elders and their families dreadfully suffer from the learning, behavioral and cognitive impairments.
openaire   +4 more sources

Age-associated DNA methylation in pediatric populations [PDF]

Genome Research, 2012
DNA methylation (DNAm) plays diverse roles in human biology, but this dynamic epigenetic mark remains far from fully characterized. Although earlier studies uncovered loci that undergo age-associated DNAm changes in adults, little is known about such changes during childhood. Despite profound DNAm plasticity during embryogenesis, monozygotic twins show
Reid S, Alisch, Benjamin G, Barwick, Pankaj, Chopra, Leila K, Myrick, Glen A, Satten, Karen N, Conneely, Stephen T, Warren   +6 more
openaire   +2 more sources

Dynamic Changes in DNA Methylation Occur during the First Year of Life in Preterm Infants

Frontiers in Endocrinology, 2016
BackgroundPreterm birth associates with a substantially increased risk of later cardiovascular disease and neurodevelopmental disorders. Understanding underlying mechanisms will facilitate the development of screening and intervention strategies to ...
Chinthika Piyasena, Chinthika Piyasena, Jessy Cartier, Nadine Provençal, Tobias Wiechmann, Batbayar Khulan, Raju Sunderesan, Gopi Menon, Jonathan R. Seckl, Rebecca M. Reynolds, Elisabeth B. Binder, Amanda J. Drake   +11 more
doaj   +1 more source

Age estimation using DNA methylation technique in forensics: a systematic review

Egyptian Journal of Forensic Sciences, 2020
Background In addition to the DNA sequence, epigenetic markers have become substantial forensic tools during the last decade. Estimating the age of an individual from human biological remains may provide information for a forensic investigation.
Chaerita Maulani, Elza Ibrahim Auerkari
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Interrelationships and determinants of aging biomarkers in cord blood

Journal of Translational Medicine, 2022
Background Increasing evidence supports the concept of prenatal programming as an early factor in the aging process. DNA methylation age (DNAm age), global genome-wide DNA methylation (global methylation), telomere length (TL), and mitochondrial DNA ...
Brigitte Reimann, Dries S. Martens, Congrong Wang, Akram Ghantous, Zdenko Herceg, Michelle Plusquin, Tim S. Nawrot   +6 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

DNA methylation-based age clocks: From age prediction to age reversion

Ageing Research Reviews, 2021
Aging as an irretrievable occurrence throughout the entire life is characterized by a progressive decline in physiological functionality and enhanced disease vulnerability. Numerous studies have demonstrated that epigenetic modifications, particularly DNA methylation (DNAm), correlate with aging and age-related diseases.
Rezvan Noroozi, Soudeh Ghafouri-Fard, Aleksandra Pisarek, Joanna Rudnicka, Magdalena Spólnicka, Wojciech Branicki, Mohammad Taheri, Ewelina Pośpiech   +7 more
openaire   +3 more sources