Results 51 to 60 of about 151,241 (263)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Age-related changes in DNA methylation levels at CpG sites in bull spermatozoa and in vitro fertilization-derived blastocyst-stage embryos revealed by combined bisulfite restriction analysis

The Journal of Reproduction and Development, 2019
Age-associated methylation changes in genomic DNA have been recently reported in spermatozoa, and these changes can contribute to decline in fertility. In a previous study, we analyzed the genome-wide DNA methylation profiles of bull spermatozoa using a ...
Kumiko TAKEDA, Eiji KOBAYASHI, Kagetomo NISHINO, Akira IMAI, Hiromichi ADACHI, Yoichiro HOSHINO, Ken IWAO, Satoshi AKAGI, Masahiro KANEDA, Shinya WATANABE   +9 more
doaj   +1 more source

Continuous Aging of the Human DNA Methylome Throughout the Human Lifespan. [PDF]

PLoS ONE, 2013
DNA methylation plays an important role in development of disease and the process of aging. In this study we examine DNA methylation at 476,366 sites throughout the genome of white blood cells from a population cohort (N = 421) ranging in age from 14 to ...
Asa Johansson, Stefan Enroth, Ulf Gyllensten   +2 more
doaj   +1 more source

DNA Methylation Markers to Assess Biological Age [PDF]

, 2019
Among the different biomarkers of aging based on omics and clinical data, DNA methylation clocks stand apart providing unmatched accuracy in assessing the biological age of both humans and animal models of aging. Here, we discuss robustness of DNA methylation clocks and bounds on their out-of-sample performance and review computational strategies for ...
Podolskiy, Dmitriy I., Gladyshev, Vadim N.   +1 more
openaire   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Genome-wide DNA methylation patterns in Daphnia magna are not significantly associated with age

Epigenetics & Chromatin
Background DNA methylation plays a crucial role in gene regulation and epigenetic inheritance across diverse organisms. Daphnia magna, a model organism in ecological and evolutionary research, has been widely used to study environmental responses ...
Ruoshui Liu, Marco Morselli, Lev Y. Yampolsky, Leonid Peshkin, Matteo Pellegrini   +4 more
doaj   +1 more source

Systematic evaluation of DNA methylation age estimation with common preprocessing methods and the Infinium MethylationEPIC BeadChip array

Clinical Epigenetics, 2018
Background The capacity of technologies measuring DNA methylation (DNAm) is rapidly evolving, as are the options for applicable bioinformatics methods.
Lisa M McEwen, Meaghan J Jones, David Tse Shen Lin, Rachel D Edgar, Lucas T Husquin, Julia L MacIsaac, Katia E Ramadori, Alexander M Morin, Christopher F Rider, Chris Carlsten, Lluís Quintana-Murci, Steve Horvath, Michael S Kobor   +12 more
doaj   +1 more source

The methylation landscape of giga-genome and the epigenetic timer of age in Chinese pine

Nature Communications, 2023
DNA methylation level declines during aging of mammals. Here, the authors report single-base resolution landscape of cytosine DNA methylation at different ages of Chinese pine and show that the global cytosine DNA methylation gradually increases as age ...
Jiang Li, Fangxu Han, Tongqi Yuan, Wei Li, Yue Li, Harry X. Wu, Hairong Wei, Shihui Niu   +7 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Age-related DNA methylation and hemostatic factors [PDF]

Blood, 2018
In this issue of Blood, a study by Ward-Caviness et al identifies a significant relationship between age-related DNA methylation changes and thrombotic risk in the elderly. They studied the relationship between hemostatic factors and 3 epigenetic measures of aging: extrinsic epigenetic age acceleration difference (EEAD), intrinsic epigenetic age ...
openaire   +2 more sources