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DNA mismatch repair and cancer
Current Opinion in Cell Biology, 1998Mutations in DNA mismatch repair (MMR) genes have been associated with hereditary nonpolyposis colorectal cancer. Studies in bacteria, yeast and mammals suggest that the basic components of the MMR system are evolutionarily conserved, but studies in eukaryotes also imply novel functions for MMR proteins.
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2010
The genome is subject to multiple forms of stress and damage that can lead to alterations in the integrity of DNA. The cell nucleus possesses several complex, integrated enzyme systems that identify altered DNA and repair it or, in the case of overwhelming damage, trigger cell death, which prevents the passage of a mutation to the next generation of ...
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The genome is subject to multiple forms of stress and damage that can lead to alterations in the integrity of DNA. The cell nucleus possesses several complex, integrated enzyme systems that identify altered DNA and repair it or, in the case of overwhelming damage, trigger cell death, which prevents the passage of a mutation to the next generation of ...
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Constitutive deficiency in DNA mismatch repair
Clinical Genetics, 2007Mutations in the DNA mismatch repair (MMR) genes are associated with the inheritance of hereditary non‐polyposis colorectal cancer, also known as Lynch syndrome, a cancer syndrome with an average age at onset of 44. Individuals presenting with colorectal cancer are diagnosed with Lynch I, whereas individuals who present with extra‐colonic tumors (such ...
K E A, Felton +2 more
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DNA mismatch repair: MutS structures bound to mismatches
Current Opinion in Structural Biology, 2001When DNA mismatch repair fails, the result is a mutator phenotype, which can lead to cancer in humans. Functional repair is dependent on the recognition of mismatches by a dimeric MutS protein, a homodimer in bacteria but a heterodimer in humans. Recent crystal structures of Thermus aquaticus and Escherichia coli MutS have revealed the structural ...
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DNA mismatch repair and Lynch syndrome
Journal of Molecular Histology, 2006The evolutionary conserved mismatch repair proteins correct a wide range of DNA replication errors. Their importance as guardians of genetic integrity is reflected by the tremendous decrease of replication fidelity (two to three orders of magnitude) conferred by their loss.
Guido, Plotz +2 more
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2016
The DNA replication machinery synthesizes ~500 DNA base pairs every second in bacteria and ~50 base pairs every second in eukaryotes [1]. Mismatches can occur in a newly synthesized DNA due to misincorporation of nucleotides by DNA polymerase or slippage during DNA replication.
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The DNA replication machinery synthesizes ~500 DNA base pairs every second in bacteria and ~50 base pairs every second in eukaryotes [1]. Mismatches can occur in a newly synthesized DNA due to misincorporation of nucleotides by DNA polymerase or slippage during DNA replication.
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DNA MISMATCH REPAIR AND GENETIC INSTABILITY
Annual Review of Genetics, 2000▪ Abstract Mismatch repair (MMR) systems play a central role in promoting genetic stability by repairing DNA replication errors, inhibiting recombination between non-identical DNA sequences and participating in responses to DNA damage. The discovery of a link between human cancer and MMR defects has led to an explosion of research on eukaryotic MMR ...
B D, Harfe, S, Jinks-Robertson
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DNA mismatch repair and colorectal cancer
The Journal of Pathology, 1998Colorectal cancer is the second commonest malignancy in the western world, accounting for 20,000 deaths in the U.K. per year. Over the last 10 years, great strides have been made in our understanding of the molecular controls governing the transition from normal mucosa, through adenoma, and finally to carcinoma.
N J, Toft, M J, Arends
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Eukaryotic DNA Mismatch Repair In Vitro
2012Mismatch repair corrects biosynthetic errors generated during DNA replication. Mismatch repair deficiency causes a mutator phenotype and directly underlies hereditary nonpolyposis colorectal cancer and some sporadic cancers. Because of remarkably high conservation of the mismatch repair machinery between the budding yeast (Saccharomyces cerevisiae) and
Fenghua, Yuan +4 more
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Molecular mechanisms of DNA mismatch repair
Mutation Research/DNA Repair, 2001DNA mismatch repair (MMR) safeguards the integrity of the genome. In its role in postreplicative repair, this repair pathway corrects base-base and insertion/deletion (I/D) mismatches that have escaped the proofreading function of replicative polymerases.
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