Results 11 to 20 of about 395,390 (239)

Recognition of two distinct elements in the RNA substrate by the RNA-binding domain of the T. thermophilus DEAD box helicase Hera [PDF]

, 2013
DEAD box helicases catalyze the ATP-dependent destabilization of RNA duplexes. Whereas duplex separation is mediated by the helicase core shared by all members of the family, flanking domains often contribute to binding of the RNA substrate.
Klostermeier, Dagmar, Linden, Martin H., Rudolph, Markus G., Steimer, Lenz, Wurm, Jan Philip, Wöhnert, Jens   +5 more
core   +1 more source

Double-stranded RNA bending by AU-tract sequences [PDF]

Nucleic Acids Research, 2020
ABSTRACTSequence-dependent structural deformations of the DNA double helix (dsDNA) have been extensively studied, where adenine tracts (A-tracts) provide a striking example for global bending in the molecule. In contrast to dsDNA, much less is known about how the nucleotide sequence affects bending deformations of double-stranded RNA (dsRNA). Using all-
Abhilash Kannan, Maarit Suomalainen, Fernando Moreno-Herrero, Alberto Marin-Gonzalez, Mikel Marin-Baquero, Rubén Pérez, Clara Aicart-Ramos, Alejandro Martín-González, J. G. Vilhena, J. G. Vilhena, Urs F. Greber   +10 more
openaire   +13 more sources

Protein-RNA interactions: a structural analysis [PDF]

, 2001
A detailed computational analysis of 32 protein-RNA complexes is presented. A number of physical and chemical properties of the intermolecular interfaces are calculated and compared with those observed in protein-double-stranded DNA and protein-single ...
Berman, HM, Daley, DT, Jones, S, Luscombe, NM, Thornton, JM   +4 more
core   +2 more sources

Mismatched Double-Stranded RNA [PDF]

Drugs in R & D, 2004
Ampligen [polyI:polyC12U] is a mismatched double-stranded RNA that acts by inducing interferon production (immunomodulator) and by activating an intracellular enzyme (RNase-L) against viral RNA transcripts (antiviral). Ampligen, currently under development by Hemispherx Biopharma in the US, acts on the immunological system through T-lymphocyte ...
openaire   +2 more sources

Two Classes of Silencing RNAs Move between Caenorhabditis elegans Tissues [PDF]

, 2013
Organism-wide RNA interference (RNAi) is due to the transport of mobile silencing RNA throughout the organism, but the identities of these mobile RNA species in animals are unknown. Here, we present genetic evidence that both the initial double-stranded
Garcia, Giancarlo, Hunter, Craig P., Jose, Antony Merlin   +2 more
core   +1 more source

Action of Nucleases on Double‐Stranded RNA [PDF]

European Journal of Biochemistry, 1976
Double‐stranded RNAs from Penicillium chrysogenum virus have been treated with RNAse III, pancreatic RNAse A and RNAse T1 and the degradation of the RNAs has been studied under different conditions. It was found that only the two former enzymes cut across both strands, RNase T1 cannot cleave double strands.RNase III was shown to digest double‐stranded ...
Maria Szekely, V G Edy, Therese Loviny, Christine Dreyer   +3 more
openaire   +2 more sources

Human NLRP1 is a sensor for double-stranded RNA

Science, 2021
A dsRNA detector in the immune toolkit Nod-like receptor (NLR) proteins recognize pathogen-associated molecular patterns within cells, which triggers the formation of signaling complexes called inflammasomes. These complexes then initiate pyroptosis, a highly inflammatory form of cell death.
Andreas Pichlmair, Karl E. Duderstadt, Karl E. Duderstadt, Stefan Bauernfried, Matthias J. Scherr, Veit Hornung, Veit Hornung   +6 more
openaire   +3 more sources

Direct comparison of nick-joining activity of the nucleic acid ligases from bacteriophage T4 [PDF]

, 2006
The genome of bacteriophage T4 encodes three polynucleotide ligases, which seal the backbone of nucleic acids during infection of host bacteria. The T4Dnl (T4 DNA ligase) and two RNA ligases [T4Rnl1 (T4 RNA ligase 1) and T4Rnl2] join a diverse array of ...
Amitsur, Arabshahi, Bebenek, Begley, Bellacosa, Blondal, Blondal, Cherepanov, Cherepanov, Clepet, Della, Desmond R. Bullard, Doherty, Engler, Fareed, Higgins, Ho, Ho, Kaufmann, Keppetipola, Kornberg, Kuhn, Lavesa-Curto, Lehman, Markham, Martins, Martins, Miller, Moore, Nandakumar, Nandakumar, Nandakumar, Nick McElhinny, Omari, Pascal, Pitcher, Pitcher, Richard P. Bowater, Rossi, Ruiz, Runnels, Rydberg, Sambrook, Sekiguchi, Shuman, Shuman, Snopek, Sriskanda, Stuart, Timson, Tomkinson, Wang, Wang, Weiss, Wilkinson, Wilkinson, Wilkinson, Wood, Wood, Worthey, Yin, Yin   +61 more
core   +4 more sources

Evidence that avian reovirus σNS is an RNA chaperone: implications for genome segment assortment. [PDF]

, 2015
Reoviruses are important human, animal and plant pathogens having 10-12 segments of double-stranded genomic RNA. The mechanisms controlling the assortment and packaging of genomic segments in these viruses, remain poorly understood.
Ault, J, Borodavka, A, Stockley, PG, Tuma, R   +3 more
core   +1 more source

Specific and heritable genetic interference by double-stranded RNA in Arabidopsis thaliana [PDF]

, 2000
We investigated the potential of double-stranded RNA interference (RNAi) with gene activity in Arabidopsis thaliana. To construct transformation vectors that produce RNAs capable of duplex formation, gene-specific sequences in the sense and antisense ...
Chuang, Chiou-Fen, Meyerowitz, Elliot M.
core   +2 more sources