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Mechanistic and therapeutic role of Drp1 in the pathogenesis of stroke
Gene, 2023Stroke had emerged as one of the leading causes of death and long-term disability across the globe. Emerging evidence suggests a significant increase in the incidence of stroke with age, which is further expected to increase dramatically owing to an ever-expanding elderly population.
Himaja, Pegadraju +2 more
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Drp1 Tubulates the ER in a GTPase-Independent Manner [PDF]
Molecular Cell, 2020 Mitochondria are highly dynamic organelles that continuously grow, divide, and fuse. The division of mitochondria is crucial for human health. During mitochondrial division, the mechano-guanosine triphosphatase (GTPase) dynamin-related protein (Drp1) severs mitochondria at endoplasmic reticulum (ER)-mitochondria contact sites, where peripheral ER ...
Robert Stähelin +2 more
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A novel cardioprotective function for DRP1 inhibition
Nature Reviews Cardiology, 2021A new study identifies a small-molecule inhibitor of a mitochondrial fission protein that reduces PCSK9 secretion and atherosclerotic plaque formation.
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Drp1 and the cytoskeleton: mechanistic nexus in mitochondrial division
Current Opinion in Physiology, 2022Dynamin-related protein 1 (Drp1), the master regulator of mitochondrial division (MD), interacts with the cytoskeletal elements, namely filamentous actin (F-actin), microtubules (MT), and septins that coincidentally converge at MD sites. However, the mechanistic contributions of these critical elements to, and their cooperativity in, MD remain poorly ...
Jason A, Mears, Rajesh, Ramachandran
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The role of Drp1 in mitophagy and cell death in the heart
Journal of Molecular and Cellular Cardiology, 2020 Maintenance of mitochondrial function and integrity is critical for normal cell survival, particularly in non-dividing cells with a high-energy demand such as cardiomyocytes. Well-coordinated quality control mechanisms in cardiomyocytes, involving mitochondrial biogenesis, mitochondrial dynamics-fission and fusion, and mitophagy, act to protect against
Mingming Tong +2 more
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Abstract P3178: Gja1-20k Is Downstream Of Drp1 And Can Rescue Drp1 Suppression In Mouse Heart
Circulation Research, 2023Dynamin-Related Protein 1 (DRP1) is a major mediator of mitochondrial fission and its mutation results with hyper-fused mitochondria and, in mice, a dilated cardiomyopathy. GJA1-20k is the most abundant N-terminus truncated isoform of Connexin 43 (Cx43) formed by internal translation and was originally identified as a trafficking subunit of Cx43.
Jennifer Hunter +4 more
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Recruitment of Drp1 in Mitochondrial Fission
The FASEB Journal, 2017Intracellular membranes are dynamically shaped by proteins including fission and fusion events important for vesicular transport, organelle trafficking, and cellular homeostasis. Yet how proteins interact with membranes to control these events is largely unknown.
John M Egner +3 more
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DRP1 in reproduction and reproductive aging
Biology of ReproductionAbstract Dynamin-related protein 1 (DRP1) is a central regulator of mitochondrial fission and plays a critical role in maintaining mitochondrial function, distribution, and turnover in reproductive cells. Mitochondrial integrity is essential for oocyte quality, folliculogenesis, fertilization, embryonic development, and ultimately ...
Cheng-Rung Huang +4 more
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Drp1-dependent mitochondrial fission in cardiovascular disease
Acta Pharmacologica Sinica, 2020Mitochondria are highly dynamic organelles undergoing cycles of fusion and fission to modulate their morphology, distribution, and function, which are referred as 'mitochondrial dynamics'. Dynamin-related protein 1 (Drp1) is known as the major pro-fission protein whose activity is tightly regulated to clear the damaged mitochondria via mitophagy ...
Jia-Yu, Jin +4 more
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