Results 191 to 200 of about 29,949 (269)

Growth differentiation factor 15 mitigates lipotoxic steatosis by preserving mitochondrial morphodynamics and augmenting fatty acid oxidation in hepatocytes and liver organoids

Diabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 3788-3806, May 2026.
Abstract Aims Growth differentiation factor 15 (GDF15) has emerged as a promising metabolic regulator with hepatoprotective properties in metabolic dysfunction‐associated steatotic liver disease (MASLD), yet its underlying mechanisms remain elusive.
Jia Li, Qi Zhou, Mengmeng Xia, Yakun Li, Junyu Wang, Manon Buist‐Homan, Vincent E. de Meijer, Hans Blokzijl, Klaas Nico Faber, Han Moshage   +9 more
wiley   +1 more source

Schisandrol B protects against lithocholic acid-induced cholestatic liver injury in mice through mitochondrial biogenesis. [PDF]

Chin Med
Yang X, Liang H, Li X, Tian J, Fan S, Huang M, Wan J, Zuo Z, Guo H, Bi H.   +9 more
europepmc   +1 more source

The Role of Piezo 1 in the Study of Intervertebral Disc Degeneration: Phenotype, Mechanism and Treatment

Orthopaedic Surgery, Volume 18, Issue 5, Page 897-914, May 2026.
As the key mechanotransducer in IVDD, Piezo1 orchestrates region‐specific degeneration across NP (senescence/ECM dysregulation), AF (apoptosis), and CEP (inflammation). This review integrates mechanistic pathways and assesses multimodal therapeutic targeting (pharmacologic/genetic/nutritional) to restore disc homeostasis.
Guangye Li, Chaoqun Feng, Haoyun Huang, Junwen Deng, Fei Yang, Rigao Chen   +5 more
wiley   +1 more source

AhR activation inhibits DRP1-induced mitochondrial fission in airway smooth muscle during asthma. [PDF]

Am J Respir Cell Mol Biol
Reza MI, Tandberg C, Kumar A, Balraj P, Thompson MA, Prakash YS, Pabelick CM, Britt RD, Sathish V.   +8 more
europepmc   +1 more source

Skeletal muscle mitochondrial marker responses to a single bout and 6 weeks of high load versus high volume resistance training in previously trained men

Experimental Physiology, Volume 111, Issue 5, Page 2564-2574, 1 May 2026.
Abstract The effects of high‐load (HL) versus high‐volume (HV) resistance training (RT) on various molecular outcomes are similar. However, mitochondrial responses remain understudied. Therefore, the purpose of this study was to interrogate mitochondrial mRNA and protein responses to acute and chronic HL versus HV RT.
Breanna Mueller, Carlton D. Fox, Hailey A. Parry, Paulo H. C. Mesquita, Christopher G. Vann, Bradley A. Ruple, Casey L. Sexton, Joshua S. Godwin, Mason M. McIntosh, Darren T. Beck, Kaelin C. Young, Stuart M. Phillips, Andreas N. Kavazis, Michael D. Roberts   +13 more
wiley   +1 more source

Inhibiting HSP27 activates the XBP1s/CerS1 interplay, which triggers DRP1-driven mitophagy, thereby protecting against cell death and promoting the KSHV lytic cycle in primary effusion lymphoma cells. [PDF]

Cell Death Discov
Gonnella R, Corrado V, Scaffidi GF, Benedetti R, Di Crosta M, Zarrella R, Gilardini Montani MS, Santarelli R, Cirone M.   +8 more
europepmc   +1 more source

Regulation of mitochondria-dynactin interaction and mitochondrial retrograde transport in axons [PDF]

, 2017
Drerup, Catherine M, Herbert, Amy L, Monk, Kelly R, Nechiporuk, Alex V   +3 more
core   +1 more source

ChREBP‐β Exacerbates Renal Tubular Disorders Caused by Fructose via ATF4

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Schematic diagram of the mechanism underlying fructose‐induced renal tubular injury via ChREBP‐β‐mediated disruption of endoplasmic reticulum and mitochondrial homeostasis. This diagram illustrates that fructose induces the transcriptional activation of ChREBP‐β, which subsequently triggers endoplasmic reticulum stress, disturbs inter‐organelle calcium
Ting Fang, Xinyu Yang, Xiaoqing Deng, Jingyi Wang, Ting Li, Hang Guo, Bei Sun, Liming Chen   +7 more
wiley   +1 more source

Mitochondrial dysfunction in Alzheimer's disease and related sex differences. [PDF]

Front Aging Neurosci
Misrani A, Ngwa C, Liu F.
europepmc   +1 more source

IFFO1 inhibits breast cancer by coordinating mitochondrial fission and fatty acid synthesis via the LaminA/C-PGC1α axis. [PDF]

Oncogenesis
Cai H, He J.
europepmc   +1 more source