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DRP1 Association in Inflammation and Metastasis: A Review
Current Drug Targets: In recent years, mitochondria have gained significant interest in the field of biomedical research due to their impact on aging, human health, and other advanced findings in metabolic functions. The latest finding shows that metabolic interventions are a leading cause of several diseases, which has sparked interest in finding new therapeutic ...
Parmar Keshri Nandan +2 more
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The impact of DRP1 on myocardial fibrosis in the obese minipig
European Journal of Clinical Investigation, 2020AbstractBackgroundThe heart is a highly oxidative tissue, thus mitochondria play a major role in maintaining optimal cardiac function. Our previous study established a dietary‐induced obese minipig with cardiac fibrosis. The aim of this study was to elucidate the role of mitochondrial dynamics in cardiac fibrosis of obese minipigs.DesignFour‐month‐old ...
Ching‐Yi Chen +4 more
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Drp1 in Ischemic Neuronal Death: An Unusual Suspect
Current Medicinal Chemistry, 2014Mitochondria play a crucial role in multitude of cellular processes including energy production, calcium signaling, and apoptosis. This remarkable organelle constantly undergoes a complex cycle of fusion and fission, a crucial quality control system for maintaining homeostasis of the cell.
H, Pradeep, B, Sharma, G K, Rajanikant
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Drp1: Focus on Diseases Triggered by the Mitochondrial Pathway
Cell Biochemistry and BiophysicsDrp1 (Dynamin-Related Protein 1) is a cytoplasmic GTPase protein encoded by the DNM1L gene that influences mitochondrial dynamics by mediating mitochondrial fission processes. Drp1 has been demonstrated to play an important role in a variety of life activities such as cell survival, proliferation, migration, and death.
Fulin, Sun +7 more
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Regulation of Mitochondrial Division by the Drp1 Receptors
2014Mitochondria can remodel their membranes by fusing or dividing. These processes are required for the proper development and viability of multicellular organisms. At the cellular level, fusion is important for mitochondrial Ca2+ homeostasis, mitochondrial DNA maintenance, mitochondrial membrane potential, and respiration.
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Chemical inhibition of mitochondrial fission via targeting the DRP1-receptor interaction
Cell Chemical Biology, 2023Hui Jiang
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Circadian Control of DRP1 Activity Regulates Mitochondrial Dynamics and Bioenergetics
Cell Metabolism, 2018Karen Schmitt +2 more
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