Results 201 to 210 of about 19,581 (227)
Inhibition of Drp1 provides neuroprotection in vitro and in vivo [PDF]
Cell Death and Differentiation, 2012 Impaired regulation of mitochondrial dynamics, which shifts the balance towards fission, is associated with neuronal death in age-related neurodegenerative diseases, such as Alzheimer's disease or Parkinson's disease. A role for mitochondrial dynamics in acute brain injury, however, has not been elucidated to date.
Carsten Culmsee +2 more
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Design and Synthesis of Drp1 Inhibitors
2022A thesis submitted in total fulfilment of the requirement for the degree of Master of Science to the Department of Chemistry and Physics, School of Molecular Science, College of Science, Health and Engineering, La Trobe University, Victoria, Australia.
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DRP1 Association in Inflammation and Metastasis: A Review
Current Drug Targets: In recent years, mitochondria have gained significant interest in the field of biomedical research due to their impact on aging, human health, and other advanced findings in metabolic functions. The latest finding shows that metabolic interventions are a leading cause of several diseases, which has sparked interest in finding new therapeutic ...
Parmar Keshri Nandan +2 more
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The phosphorylation status of Ser-637 in dynamin-related protein 1 (Drp1) does not determine Drp1 recruitment to mitochondria [PDF]
Journal of Biological Chemistry, 2019 Recruitment of the GTPase dynamin-related protein 1 (Drp1) to mitochondria is a central step required for mitochondrial fission. Reversible Drp1 phosphorylation has been implicated in the regulation of this process, but whether Drp1 phosphorylation at Ser-637 determines its subcellular localization and fission activity remains to be fully elucidated ...
Jian Zhao +2 more
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The impact of DRP1 on myocardial fibrosis in the obese minipig
European Journal of Clinical Investigation, 2020AbstractBackgroundThe heart is a highly oxidative tissue, thus mitochondria play a major role in maintaining optimal cardiac function. Our previous study established a dietary‐induced obese minipig with cardiac fibrosis. The aim of this study was to elucidate the role of mitochondrial dynamics in cardiac fibrosis of obese minipigs.DesignFour‐month‐old ...
Ching‐Yi Chen +4 more
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Mechanisms of Drp1 Recruitment to Mitochondria
2017Dynamin-related protein 1 (Drp1) is a GTPase of the dynamin superfamily that catalyzes mitochondrial fission in the cell. Cytosolic Drp1 is recruited to mitochondria by receptors anchored to the outer mitochondrial membrane. Once there, Drp1 assembles into a complex around the mitochondrial circumference to drive division via a GTP-dependent ...
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Drp1 in Ischemic Neuronal Death: An Unusual Suspect
Current Medicinal Chemistry, 2014Mitochondria play a crucial role in multitude of cellular processes including energy production, calcium signaling, and apoptosis. This remarkable organelle constantly undergoes a complex cycle of fusion and fission, a crucial quality control system for maintaining homeostasis of the cell.
H, Pradeep, B, Sharma, G K, Rajanikant
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Functional characterization of human DRP1
2012Das Ziel dieser Studie war die Charakterisierung des Proteins DRP1 (dynamin related protein 1), der Hauptfaktor bei der mitochondrialen Teilung, auf biochemischer und biophysikalischer Ebene. Mitochondrien spielen unter anderem im Energiehaushalt, in der Apoptose und der Homöostase von Kalzium eine entscheidende Rolle.
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Drp1: Focus on Diseases Triggered by the Mitochondrial Pathway
Cell Biochemistry and BiophysicsDrp1 (Dynamin-Related Protein 1) is a cytoplasmic GTPase protein encoded by the DNM1L gene that influences mitochondrial dynamics by mediating mitochondrial fission processes. Drp1 has been demonstrated to play an important role in a variety of life activities such as cell survival, proliferation, migration, and death.
Fulin, Sun +7 more
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FAK regulates cardiomyocyte mitochondrial fission and function through Drp1
FEBS Journal, 2022Yu-Wang Chang, Chien-Chang Chen
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