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Functional characterization of human DRP1
2012Das Ziel dieser Studie war die Charakterisierung des Proteins DRP1 (dynamin related protein 1), der Hauptfaktor bei der mitochondrialen Teilung, auf biochemischer und biophysikalischer Ebene. Mitochondrien spielen unter anderem im Energiehaushalt, in der Apoptose und der Homöostase von Kalzium eine entscheidende Rolle.
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Mitochondrial chaperone DnaJA3 induces Drp1-dependent mitochondrial fragmentation
The International Journal of Biochemistry & Cell Biology, 2012Mitochondrial morphology is dynamic and controlled by coordinated fusion and fission pathways. The role of mitochondrial chaperones in mitochondrial morphological changes and pathology is currently unclear. Here we report that altered levels of DnaJA3 (Tid1/mtHsp40) a mitochondrial member of the DnaJ protein family, and heat shock protein (Hsp) co ...
Adam N, Elwi +4 more
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Design and Synthesis of Drp1 Inhibitors
2022A thesis submitted in total fulfilment of the requirement for the degree of Master of Science to the Department of Chemistry and Physics, School of Molecular Science, College of Science, Health and Engineering, La Trobe University, Victoria, Australia.
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DRP1 Association in Inflammation and Metastasis: A Review
Current Drug Targets: In recent years, mitochondria have gained significant interest in the field of biomedical research due to their impact on aging, human health, and other advanced findings in metabolic functions. The latest finding shows that metabolic interventions are a leading cause of several diseases, which has sparked interest in finding new therapeutic ...
Parmar Keshri Nandan +2 more
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Mechanisms of Drp1 Recruitment to Mitochondria
2017Dynamin-related protein 1 (Drp1) is a GTPase of the dynamin superfamily that catalyzes mitochondrial fission in the cell. Cytosolic Drp1 is recruited to mitochondria by receptors anchored to the outer mitochondrial membrane. Once there, Drp1 assembles into a complex around the mitochondrial circumference to drive division via a GTP-dependent ...
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Novel Mitochondrial Drp1 Inhibitors for Cardioprotection
Heart, Lung and Circulation, 2021A. Rosdah +7 more
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DRP1-Mediated Mitophagy: Safeguarding Obese Hearts From Cardiomyopathy
Circulation Research, 2023Xi Fang, Åsa B. Gustafsson
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