Results 1 to 10 of about 83,951 (257)

Use of Pleural Fluid Digital PCR Analysis to Improve the Diagnosis of Pleural Tuberculosis

Microbiology Spectrum, 2022
The diagnosis of pleural tuberculosis (TB) remains difficult due to the paucity of Mycobacterium tuberculosis in pleural fluid (PF). This study aimed to improve pleural TB diagnosis using highly sensitive digital PCR (dPCR) technique.
Zihui Li, Qi Sun, Boping Du, Hongyan Jia, Jing Dong, Lingna Lyu, Chuanzhi Zhu, Aiying Xing, Xinting Yang, Rongrong Wei, Xiaoyou Chen, Zongde Zhang, Liping Pan   +12 more
doaj   +1 more source

Novel oxazolidinones harbor potent in vitro activity against the clinical isolates of multidrug-resistant Mycobacterium tuberculosis in China

Frontiers in Medicine, 2022
ObjectiveTo investigate the in vitro activities of five oxazolidinones in parallel against the reference strains of different mycobacterial species and clinical isolates of Mycobacterium tuberculosis (Mtb), and shed light on the differences in the ...
Chenqian Wang, Chenqian Wang, Guirong Wang, Fengmin Huo, Yi Xue, Junnan Jia, Lingling Dong, Liping Zhao, Fen Wang, Hairong Huang, Hongfei Duan   +10 more
doaj   +1 more source

Single-nucleotide polymorphisms and activities of indoleamine 2,3-dioxygenase isoforms, IDO1 and IDO2, in tuberculosis patients

Hereditas, 2022
Purpose To explore the role and effects of the single-nucleotide polymorphisms (SNPs) of the two functionally related indoleamine 2,3-dioxygenase (IDO) isoforms on IDO activity in the Chinese Han ethnic population.
Tingming Cao, Guangming Dai, Hongqian Chu, Chengcheng Kong, Huijuan Duan, Na Tian, Zhaogang Sun   +6 more
doaj   +1 more source

Nosiheptide Harbors Potent In Vitro and Intracellular Inhbitory Activities against Mycobacterium tuberculosis

Microbiology Spectrum, 2022
Multidrug-resistant tuberculosis (MDR-TB) is often associated with poor clinical outcomes. In this study, we evaluated the potential of nosiheptide (NOS) as a new drug candidate for treating Mycobacterium tuberculosis infections, including MDR-TB.
Xia Yu, Rui Zhu, Zhi Geng, Yaoyao Kong, Fen Wang, Lingling Dong, Liping Zhao, Yi Xue, Xiaochi Ma, Hairong Huang   +9 more
doaj   +1 more source

Drug resistant tuberculosis [PDF]

BMJ, 1995
EDITOR,—Concern is growing over the spread of drug resistant Mycobacterium tuberculosis. New evidence suggests that this spread may be increasing in certain sections of the British population. The recent advances in molecular techniques have equipped us with the means to make substantial inroads into the possible impact of drug resistant tuberculosis.1
openaire   +6 more sources

Bacteriomes in lesions of pulmonary tuberculosis and its association with status of Mycobacterium tuberculosis excretion

BMC Microbiology, 2022
Background Bacteria in lung play an important role in sustaining lung health. Understanding the characteristics of bacteriomes in lesions of pulmonary tuberculosis (TB) patients, who excrete Mycobacterium tuberculosis (MTB), is important for TB ...
Weili Du, Yingli Zhao, Li Zhang, Jialu Che, Zichen Liu, Kun Li, Nanying Che   +6 more
doaj   +1 more source

In Vitro Antimicrobial Activities of Tigecycline, Eravacycline, Omadacycline, and Sarecycline against Rapidly Growing Mycobacteria

Microbiology Spectrum, 2023
Infections caused by rapidly growing mycobacteria (RGM) have increased globally. Chemotherapy against these infections is challenging due to the minimal antimicrobial choices available.
Tingting Zhang, Jian Du, Lingling Dong, Fen Wang, Liping Zhao, Junnan Jia, Congli Wang, Mengli Cheng, Xia Yu, Hairong Huang   +9 more
doaj   +1 more source

Drug-resistant tuberculosis

The Lancet, 1993
Multidrug-resistant tuberculosis (MDRTB) is an iatrogenic disease that is emerging as a major infectious disease problem throughout the world. The AIDS pandemic, increased incidence of tuberculosis in populations with easy access to antituberculosis medications, the deterioration of the public health infrastructure, and inadequate training of health ...
B A, Hanna, S, Bonk, L K, Tick
openaire   +4 more sources

Xpert MTB/RIF Ultra enhanced tuberculous pleurisy diagnosis for patients with unexplained exudative pleural effusion who underwent a pleural biopsy via thoracoscopy: A prospective cohort study

International Journal of Infectious Diseases, 2021
Introduction: To evaluate the performance of Xpert MTB/RIF Ultra (Xpert-Ultra) in testing pleural tissue and fluid collected by medical thoracoscopy among patients with unexplained exudative pleural effusion.
Shan Gao, Chong Wang, Xia Yu, Tianlu Teng, Yuanyuan Shang, Junnan Jia, Lingling Dong, Liping Zhao, Shuku Liu, Naihui Chu, Hairong Huang   +10 more
doaj   +1 more source

Evaluation of digital PCR assay in detection of M.tuberculosis IS6110 and IS1081 in tuberculosis patients plasma

BMC Infectious Diseases, 2020
Background Tuberculosis is still a significant diagnostic and therapeutic challenge with high proportion of smear- and culture- negative incidences worldwide. The conventional diagnostic tests are time-consuming and have a low sensitivity. Digital PCR is
Lingna Lyu, Zihui Li, Liping Pan, Hongyan Jia, Qi Sun, Qiuyue Liu, Zongde Zhang   +6 more
doaj   +1 more source