Results 21 to 30 of about 83,951 (257)

Comparison of the in vitro antibacterial activity of ofloxacin, levofloxacin, moxifloxacin, sitafloxacin, finafloxacin, and delafloxacin against Mycobacterium tuberculosis strains isolated in China

Heliyon, 2023
Objective: The resistance of Mycobacterium tuberculosis (Mtb) to currently available fluoroquinolones (FQs), namely ofloxacin (OFX), levofloxacin (LFX), and moxifloxacin (MFX), renders the treatment of TB infections less successful.
Yaoyao Kong, Zhi Geng, Guanglu Jiang, Junnan Jia, Fen Wang, Xiaoyi Jiang, Yuzhen Gu, Zhenyan Qi, Naihui Chu, Hairong Huang, Xia Yu   +10 more
doaj   +1 more source

EasyNAT MTC assay: A simple, rapid, and low-cost cross-priming amplification method for the detection of mycobacterium tuberculosis suitable for point-of-care testing

Emerging Microbes and Infections, 2021
More sensitive, rapid, and affordable diagnostic tools for pulmonary tuberculosis (PTB) are urgently needed. This study aimed to assess the performance of EasyNAT MTC (abbreviation: EasyNAT) (Ustar Biotechnologies, China), a novel isothermal ...
Zhuman Zhang, Jian Du, Tao Liu, Fen Wang, Junnan Jia, Lingling Dong, Liping Zhao, Yi Xue, Guanglu Jiang, Xia Yu, Hairong Huang   +10 more
doaj   +1 more source

In Vitro Activity of the Sudapyridine (WX-081) against Non-Tuberculous Mycobacteria Isolated in Beijing, China

Microbiology Spectrum, 2022
Sudapyridine (WX-081) is a structural analog of bedaquiline (BDQ), which shows an anti-tuberculosis activity but, unlike BDQ, did not prolong QT interval (QT) in animal model studies.
Rui Zhu, Yuanyuan Shang, Suting Chen, Hua Xiao, Ruyan Ren, Fen Wang, Yi Xue, Lei Li, Yongguo Li, Naihui Chu, Hairong Huang   +10 more
doaj   +1 more source

Biological interpretation of the sporadic sputum smear-positive-culture-negative outcome for patients with tuberculosis undertaking treatments

Frontiers in Public Health, 2023
IntroductionThe objective of the study was to identify the causes of smear-positive-culture-negative (S+/C–) outcomes of patients with tuberculosis during the treatment course.MethodsA laboratory-based retrospective study was performed at the Beijing ...
Jingjing Luo, Jingjing Luo, Jingjing Luo, Xia Yu, Lingling Dong, Fengmin Huo, Yifeng Ma, Qian Liang, Yuanyuan Shang, Hairong Huang   +9 more
doaj   +1 more source

Extensively drug resistant tuberculosis [PDF]

BMJ, 2006
Tuberculosis outbreaks in the developed world are newsworthy. However in the developing world where deaths from tuberculosis are common it takes something exceptional for an outbreak to attract much attention. In response to a recent report at the 16th international AIDS conference and to increasing South African media reports the World Health ...
Lawn, Stephen D, Wilkinson, Robert
openaire   +3 more sources

GeneXpert MTB/RIF assay in the diagnosis of urinary tuberculosis from urine specimens

Scientific Reports, 2017
Conventional bacteriological methods are not generally helpful in diagnosing urinary tuberculosis (UTB). GeneXpert is endorsed for the detection of pulmonary tuberculosis, whereas the data on its utility for urine specimens is limited.
Yu Pang, Yuanyuan Shang, Jie Lu, Qian Liang, Lingling Dong, Yunxu Li, Liping Zhao, Guanglu Jiang, Hairong Huang   +8 more
doaj   +1 more source

Xpert MTB/RIF Ultra outperformed the Xpert assay in tuberculosis lymphadenitis diagnosis: a prospective head-to-head cohort study

International Journal of Infectious Diseases, 2022
Objectives: Xpert Mycobacterium tuberculosis/rifampin (MTB/RIF) Ultra (Xpert-Ultra) has shown better sensitivity in comparison with Xpert MTB/RIF (Xpert) in extrapulmonary tuberculosis (TB), whereas the head-to-head comparison of these methods in TB ...
Xia Yu, Tingting Zhang, Yaoyao Kong, Fen Wang, Lingling Dong, Ming Han, Hairong Huang   +6 more
doaj   +1 more source

Increased prevalence of levofloxacin-resistant Mycobacterium tuberculosis in China is associated with specific mutations within the gyrA gene

International Journal of Infectious Diseases, 2020
Objectives: To compare the prevalence of levofloxacin (LFX) resistance and the population structure of Mycobacterium tuberculosis (MTB) with different mutations conferring LFX resistance between 2005 and 2015.
Fengmin Huo, Fuzhen Zhang, Yi Xue, Yuanyuan Shang, Qian Liang, Yifeng Ma, Yunxu Li, Liping Zhao, Yu Pang   +8 more
doaj   +1 more source

Characterization of Mycobacterium tuberculosis strains in Beijing, China: drug susceptibility phenotypes and Beijing genotype family transmission

BMC Infectious Diseases, 2018
Background The most prevalent strains of Mycobacterium tuberculosis (M.tb) in Beijing belong to the Beijing genotype family. The influence of Beijing genotype prevalence on the development of drug resistance, and the association of infection with Beijing
Yi Liu, Xuxia Zhang, Yuqing Zhang, Yong Sun, Cong Yao, Wei Wang, Chuanyou Li   +6 more
doaj   +1 more source

Light-activated nanomaterials for tumor immunotherapy

Frontiers in Chemistry, 2022
Tumor immunotherapy mainly relies on activating the immune system to achieve antitumor treatment. However, the present tumor immunotherapy used in the clinic showed low treatment efficacy with high systematic toxicity.
Fang Wang, Fang Wang, Huijuan Duan, Huijuan Duan, Weizhe Xu, Weizhe Xu, Gang Sheng, Gang Sheng, Zhaogang Sun, Zhaogang Sun, Hongqian Chu, Hongqian Chu   +11 more
doaj   +1 more source