Results 41 to 50 of about 83,951 (257)

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Positron Emission Tomography Imaging of Bacterial Infections With an Enterobactin Analog to Monitor Treatment Efficacy With a Catechol Antibiotic

Angewandte Chemie, EarlyView.
Synopsis. The [68Ga]GaIII‐TREN‐CAM radiochelate selectively accumulates in Gram‐negative sites of infection and noninvasively monitors treatment response a siderophore antibiotic. ABSTRACT Positron emission tomography (PET) is an emerging tool under clinical investigation for the detection of bacterial infections.
M. Andrey Joaqui‐Joaqui, Phuong Nguyen Tran, Axia Marlin, Fiona Armstrong‐Pavlik, Minhua Cao, Valérie C. Pierre, Eszter Boros   +6 more
wiley   +2 more sources

Performance of stool-based Xpert MTB/RIF assay in the diagnosis of presumptive pulmonary tuberculosis in adults unable to expectorate sputum

Microbiology Spectrum
This study aimed to compare the performance of stool-based Xpert MTB/RIF(Xpert) assay (Cepheid, USA) against that of smear, culture, and Xpert using respiratory tract specimens (RTS) and stool samples in the diagnosis of adult pulmonary tuberculosis (PTB)
Yi Xue, Siyi Chen, Weihe Zhang, Junnan Jia, Fen Wang, Lingling Dong, Liping Zhao, Hairong Huang, Xia Yu   +8 more
doaj   +1 more source

Xpert MTB/RIF and GenoType MTBDRplus assays for the rapid diagnosis of bone and joint tuberculosis

International Journal of Infectious Diseases, 2015
Background: Bone and joint tuberculosis (BJTB) constitutes about 10–20% of the extrapulmonary tuberculosis (EPTB) cases in China. The GenoType MTBDRplus assay (MTBDR) has been endorsed by the World Health Organization (WHO) for the diagnosis of pulmonary
Yunting Gu, Guirong Wang, Weijie Dong, Yunxu Li, Yifeng Ma, Yuanyuan Shang, Shibing Qin, Hairong Huang   +7 more
doaj   +1 more source

Case report: A 9-year systematic treatment failure of a pulmonary tuberculosis patient

Frontiers in Public Health, 2022
ObjectiveTo explore the reasons of failure in a case of pulmonary tuberculosis (PTB) after 9 years systematic treatment.MethodsWe extracted the patients' treatment history, drug susceptibility testing (DST), Computed tomography (CT) images, and sequenced
Hui Jiang, Hui Jiang, Chendi Zhu, Chendi Zhu, Chendi Zhu, Liyi Qin, Liyi Qin, Liyi Qin, Xiaoguang Wu, Xiaoguang Wu, Jinfeng Yin, Jinfeng Yin, Jinfeng Yin, Yijia Guo, Yijia Guo, Yijia Guo, Huan Ma, Junnan Jia, Junnan Jia, Junnan Jia, Fengmin Huo, Fengmin Huo, Fengmin Huo, Yi Xue, Yi Xue, Yi Xue, Mengqiu Gao, Mengqiu Gao, Weimin Li, Weimin Li, Weimin Li   +30 more
doaj   +1 more source

Drug-resistant Spinal Tuberculosis

Indian Journal of Orthopaedics, 2018
Drug-resistant spinal tuberculosis (TB) is an emerging health problem in both developing and developed countries. In this review article, we aim to define management protocols for suspicion, diagnosis, and treatment of such patients. Spinal TB is a deep-seated paucibacillary lesion, and the demonstration of acid-fast bacilli on Ziehl-Neelsen staining ...
Jain, Anil K, Jaggi, Karan Raj, Bhayana, Himanshu, Saha, Rumpa   +3 more
openaire   +2 more sources

Enhanced Infection Resistance and Regenerative Healing of Titanium Implants via Peptide‐Loaded Biodegradable Coatings

Advanced Materials Technologies, EarlyView.
This study presents a new biodegradable coating for titanium implants using a natural antimicrobial peptide, caerin 1.9. Applied via solvent casting, the coating offers sustained antibacterial protection and promotes healing. Tested on 3D‐printed porous titanium scaffolds, it effectively prevented infection—including against resistant bacteria—while ...
Hejie Li, Tianfang Wang, Nicolas Soro, Guoying Ni, Meg Allom, D. İpek Kurtböke, Xiaosong Liu, Damon Kent   +7 more
wiley   +1 more source

In vitro susceptibility of nontuberculous mycobacteria in China

BMC Infectious Diseases
Objectives This study aimed to measure the prevalence of resistance to antimicrobial agents, and explore the risk factors associated with drug resistance by using nontuberculous Mycobacteria (NTM) isolates from China.
Weicong Ren, Yaoju Tan, Zichun Ma, Yuanyuan Shang, Shanshan Li, Xuxia Zhang, Wei Wang, Cong Yao, Jinfeng Yuan, Liang Li, Yu Pang   +10 more
doaj   +1 more source

Significant difference in Th1/Th2 paradigm induced by tuberculosis-specific antigens between IGRA-positive and IGRA-negative patients

Frontiers in Immunology, 2022
False negative interferon-γ release assay (IGRA) results constitute the major dilemma for the diagnosis of tuberculosis (TB) infections. Herein, we conducted a cohort study to compare the host immunological response to TB-specific antigens between active
Qiang Li, Weicong Ren, Jinfeng Yuan, Haiping Guo, Yuanyuan Shang, Wei Wang, Junhua Pan, Mengqiu Gao, Yu Pang   +8 more
doaj   +1 more source

Attenuated Bacteria‐Based Tumor Therapy: Clinical Application Risks, Marketing Approval Restrictions, and Coping Strategies

Advanced Science, EarlyView.
This review comprehensively overviews attenuated bacteria‐based tumor therapy, highlighting key methodologies and recent progress. It examines strategies for enhancing safety, stabilizing efficacy, optimizing manufacturing, and navigating regulatory pathways.
Yucheng Liu, Junhong Yao, Jiaxin Deng, Minjie Zhou, Kaiyue Shen, Shishuo Sun, Xiaoge Gao, Qing Zhang, Haiheng Xu   +8 more
wiley   +1 more source