Results 1 to 10 of about 1,436,718 (300)
Selinexor Overcomes Hypoxia-Induced Drug Resistance in Multiple Myeloma [PDF]
Translational Oncology, 2017 Increased levels of the nuclear export protein, exportin 1 (XPO1), were demonstrated in multiple myeloma (MM) patients. Targeting XPO1 with selinexor (the selective inhibitor of nuclear export; SINE compound KPT-330) demonstrates broad antitumor activity
Barbara Muz +4 more
doaj +4 more sources
Multiple Mechanisms Synergistically Induce Pseudomonas Aeruginosa Multiple Drug Resistance
Microbiology Research, 2023 The aim of this study was to understand the molecular epidemiological characteristics and drug resistance mechanism of carbapenem-resistant Pseudomonas aeruginosa (CRPA) and to provide a theoretical basis for the prevention and treatment of CRPA ...
Pei Dai +6 more
doaj +3 more sources
Circumvention of Mcl-1-Dependent Drug Resistance by Simultaneous Chk1 and MEK1/2 Inhibition in Human Multiple Myeloma Cells [PDF]
, 2014 The anti-apoptotic protein Mcl-1 plays a major role in multiple myeloma (MM) cell survival as well as bortezomib- and microenvironmental forms of drug resistance in this disease.
Bodie, Wesley W. +11 more
core +22 more sources
Revista Panamericana de Salud Pública, 2023 Objectives. To determine the proportion of Salmonella enterica in fecal samples of live pigs with suspected salmonellosis analyzed at the diagnostic unit of the University of Antioquia, Colombia between 2019 and 2021, and examine the serotypes and ...
Juana L. Vidal +6 more
doaj +1 more source
Drug-resistant tuberculosis in Colombia, 2013-2018: Case-control study
Biomédica: revista del Instituto Nacional de Salud, 2023 Introduction. Multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB) is difficult to control, has high morbidity and mortality, and demands priority public health intervention. In Colombia, MDR/RR-TB has been becoming more widespread annually.
Gloria Mercedes Puerto +4 more
doaj +1 more source
Revista Panamericana de Salud Pública, 2020 Acinetobacter baumannii is considered to be a worldwide threat to public health due to its high antimicrobial resistance rates and the severe infections it can cause. Little is known about this pathogen’s resistance in Central America.
Julio Cesar Zuniga-Moya +9 more
doaj +1 more source
Туберкулез и болезни лёгких, 2022 The objective: to evaluate main parameters of cellular, humoral immunity and natural resistance in tuberculosis patients with primary and acquired multiple drug resistance; to study the correlation of these parameters with clinical and radiological ...
E. Lesnik, S. Ginda
doaj +1 more source
Extended-Spectrum beta-Lactamase and Multidrug Resistance in Urinary Sepsis Patients Admitted to the Intensive Care Unit [PDF]
Korean Journal of Critical Care Medicine, 2014 BACKGROUND: The role of extended-spectrum beta-lactamase (ESBL)-producing or multidrug-resistant (MDR) organisms in patients with sepsis secondary to urinary traction infection (UTI) has not been investigated extensively in the intensive care unit (ICU ...
Bumjoon Kim +8 more
doaj +1 more source
Optimized Treatment Schedules for Chronic Myeloid Leukemia [PDF]
, 2016 Over the past decade, several targeted therapies (e.g. imatinib, dasatinib, nilotinib) have been developed to treat Chronic Myeloid Leukemia (CML). Despite an initial response to therapy, drug resistance remains a problem for some CML patients.
Dingli, David +4 more
core +5 more sources
Epigenetics as a mechanism driving polygenic clinical drug resistance [PDF]
, 2006 Aberrant methylation of CpG islands located at or near gene promoters is associated with inactivation of gene expression during tumour development.
A Balmain +57 more
core +2 more sources