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Molecular mechanisms in multiple myeloma drug resistance [PDF]

open access: yesJournal of Clinical Pathology, 2015
Multiple myeloma (MM) is predominantly an incurable malignancy despite high-dose chemotherapy, autologous stem cell transplant and novel agents. MM is a genetically heterogeneous disease and the complexity increases as the disease progresses to a more ...
N. Nikesitch, S. Ling
semanticscholar   +5 more sources

The role of non‐coding RNAs in drug resistance of oral squamous cell carcinoma and therapeutic potential

open access: yesCancer Communications, 2021
Oral squamous cell carcinoma (OSCC), the eighth most prevalent cancer in the world, arises from the interaction of multiple factors including tobacco, alcohol consumption, and betel quid.
Xiang Meng   +7 more
doaj   +2 more sources

Role of epigenetics-microRNA axis in drug resistance of multiple myeloma

open access: yesJournal of Hematology & Oncology, 2017
Despite administration of novel therapies, multiple myeloma (MM) remains incurable with resistance to drugs leading to relapse in most patients. Thus, it is critical to understand the detailed mechanisms underlying the drug resistance of MM and develop ...
Nasrin Rastgoo   +3 more
doaj   +2 more sources

Multidrug-resistant Salmonella spp. in fecal samples of pigs with suspected salmonellosis in Antioquia, Colombia, 2019–2021

open access: yesRevista Panamericana de Salud Pública, 2023
Objectives. To determine the proportion of Salmonella enterica in fecal samples of live pigs with suspected salmonellosis analyzed at the diagnostic unit of the University of Antioquia, Colombia between 2019 and 2021, and examine the serotypes and ...
Juana L. Vidal   +6 more
doaj   +1 more source

The genetic heterogeneity and drug resistance mechanisms of relapsed refractory multiple myeloma

open access: yesNature Communications, 2022
Multiple myeloma is the second most common hematological malignancy. Despite significant advances in treatment, relapse is common and carries a poor prognosis.
Josh N. Vo   +39 more
semanticscholar   +1 more source

Review on Multiple Facets of Drug Resistance: A Rising Challenge in the 21st Century

open access: yesJournal of Xenobiotics, 2021
With the advancements of science, antibiotics have emerged as an amazing gift to the human and animal healthcare sectors for the treatment of bacterial infections and other diseases.
M. Saha, Agniswar Sarkar
semanticscholar   +1 more source

Multiple Mechanisms Synergistically Induce Pseudomonas Aeruginosa Multiple Drug Resistance

open access: yesMicrobiology Research, 2023
The aim of this study was to understand the molecular epidemiological characteristics and drug resistance mechanism of carbapenem-resistant Pseudomonas aeruginosa (CRPA) and to provide a theoretical basis for the prevention and treatment of CRPA ...
Pei Dai   +6 more
doaj   +1 more source

Emerging Therapeutic Strategies to Overcome Drug Resistance in Multiple Myeloma

open access: yesCancers, 2021
Simple Summary Multiple myeloma is a deadly blood cancer, but fortunately drug development has substantially prolonged the lifespan of patients to average more than a decade after diagnosis with optimal therapy.
Lorraine N Davis, Daniel W. Sherbenou
semanticscholar   +1 more source

Drug-resistant tuberculosis in Colombia, 2013-2018: Case-control study

open access: yesBiomédica: revista del Instituto Nacional de Salud, 2023
Introduction. Multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB) is difficult to control, has high morbidity and mortality, and demands priority public health intervention. In Colombia, MDR/RR-TB has been becoming more widespread annually.
Gloria Mercedes Puerto   +4 more
doaj   +1 more source

Antimicrobial profile of Acinetobacter baumannii at a tertiary hospital in Honduras: a cross-sectional analysis

open access: yesRevista Panamericana de Salud Pública, 2020
Acinetobacter baumannii is considered to be a worldwide threat to public health due to its high antimicrobial resistance rates and the severe infections it can cause. Little is known about this pathogen’s resistance in Central America.
Julio Cesar Zuniga-Moya   +9 more
doaj   +1 more source

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