Results 31 to 40 of about 2,071,500 (370)
Chromothripsis in Treatment Resistance in Multiple Myeloma [PDF]
Genomics & Informatics, 2017 Multiple myeloma (MM) is a malignant disease caused by an abnormal proliferation of plasma cells, of which the prognostic factors include chromosomal abnormality, β-2 microglobulin, and albumin. Recently, the term chromothripsis has emerged, which is the
Kyoung Joo Lee +7 more
doaj +1 more source
Tyrosol induces multiple drug resistance in yeast Saccharomyces cerevisiae
Frontiers in Microbiology, 2023 In yeast, multiple (pleiotropic) drug resistance (MDR) transporters efflux xenobiotics from the cytoplasm to the environment. Additionally, upon the accumulation of xenobiotics in the cells, MDR genes are induced.
Elizaveta O. Noskova +5 more
doaj +1 more source
The Transfer of Sphingomyelinase Contributes to Drug Resistance in Multiple Myeloma
Cancers, 2019 Multiple myeloma (MM) is well-known for the development of drug resistance, leading to relapse. Therefore, finding novel treatment strategies remains necessary. By performing a lipidomics assay on MM patient plasma, we aimed to identify new targets.
S. Faict +13 more
semanticscholar +1 more source
Frontiers in Cellular and Infection Microbiology, 2022 Pseudomonas aeruginosa is an opportunistic pathogen causing nosocomial infections in severely ill and immunocompromised patients. Ubiquitously disseminated in the environment, especially in hospitals, it has become a major threat to human health due to ...
Chongbing Liao +4 more
semanticscholar +1 more source
Systems analysis of drug-induced receptor tyrosine kinase reprogramming following targeted mono- and combination anti-cancer therapy [PDF]
, 2014 The receptor tyrosine kinases (RTKs) are key drivers of cancer progression and targets for drug therapy. A major challenge in anti-RTK treatment is the dependence of drug effectiveness on co-expression of multiple RTKs which defines resistance to single ...
Bown, James L. +8 more
core +6 more sources
Microbiology Research, 2016 Due to the increasing prevalence of infections caused by resistant bacteria and especially multiple drug resistance Enterobacteriaceae, availability of alternative effective antibiotics is restricted.
Fatemeh Yeganeh Sefidan +2 more
doaj +1 more source
miR-874 regulates multiple-drug resistance in gastric cancer by targeting ATG16L1.
International Journal of Oncology, 2018 Chemotherapy is an important treatment option for gastric cancer (GC); however, chemotherapy usually fails due to drug resistance, particularly multidrug resistance (MDR). In our previous studies, microRNA (miR)‑874 was demonstrated to serve an important
Haijin Huang +4 more
semanticscholar +1 more source
Adaptive HIV-1 evolutionary trajectories are constrained by protein stability [PDF]
, 2017 Despite the use of combination antiretroviral drugs for the treatment of HIV-1 infection, the emergence of drug resistance remains a problem. Resistance may be conferred either by a single mutation or a concerted set of mutations.
Kandathil, Shaun M. +3 more
core +1 more source
Multiple drug resistance in the canine hookworm Ancylostoma caninum: an emerging threat?
Parasites & Vectors, 2019 The canine hookworm, Ancylostoma caninum is the most prevalent and important intestinal nematode parasite of dogs in the USA. Hookworms are typically well controlled by treatment with all commonly used anthelmintics that are approved for this use in dogs.
Pablo D. Jimenez Castro +5 more
semanticscholar +1 more source
Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management
Journal of Hematology & Oncology, 2022 Drug resistance represents a major obstacle in cancer management, and the mechanisms underlying stress adaptation of cancer cells in response to therapy-induced hostile environment are largely unknown. As the central organelle for cellular energy supply,
P. Jin +6 more
semanticscholar +1 more source