Results 41 to 50 of about 2,071,500 (370)
Management of multiple drug-resistant tuberculosis
Respiratory Medicine, 2003 There has been a worldwide increase in multiple drug-resistant tuberculosis (MDR-TB) which has in the past been associated with a poor prognosis. In the U.K., about half of the cases live in the London area and we have set out to obtain further information on their treatment and outcome.
Hutchison, D C S +2 more
openaire +4 more sources
Drugs Resistance Analysis from Scarce Health Records via Multi-task Graph Representation [PDF]
arXiv, 2023 Clinicians prescribe antibiotics by looking at the patient's health record with an experienced eye. However, the therapy might be rendered futile if the patient has drug resistance. Determining drug resistance requires time-consuming laboratory-level testing while applying clinicians' heuristics in an automated way is difficult due to the categorical ...
arxiv
Endoplasmic reticulum stress in the development of multiple myeloma and drug resistance
Clinical & Translational Immunology, 2018 Multiple myeloma (MM) is a haematological malignancy of mature antibody‐secreting plasma cells. Currently, MM is incurable, but advances in drug treatments have increased patient lifespan.
N. Nikesitch +3 more
semanticscholar +1 more source
Frontiers in Oncology, 2022 Breast cancer is the most frequent type of malignancy in women worldwide, and drug resistance to the available systemic therapies remains a major challenge.
Taniya Saha, K. Lukong
semanticscholar +1 more source
ALNSynergy: a graph convolutional network with multi-representation alignment for drug synergy prediction [PDF]
arXiv, 2023 Drug combination refers to the use of two or more drugs to treat a specific disease at the same time. It is currently the mainstream way to treat complex diseases. Compared with single drugs, drug combinations have better efficacy and can better inhibit toxicity and drug resistance.
arxiv
Modelling drug delivery from multiple emulsions [PDF]
Phys. Rev. E 102, 023114 (2020), 2020 We present a mechanistic model of drug release from a multiple emulsion into an external surrounding fluid. We consider a single multi-layer droplet where the drug kinetics are described by a pure diffusive process through different liquid shells. The multi-layer problem is described by a system of diffusion equations coupled via interlayer conditions ...
arxiv +1 more source
Targeting Drug Chemo-Resistance in Cancer Using Natural Products
Biomedicines, 2021 Cancer is one of the leading causes of death globally. The development of drug resistance is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms to reduce the therapeutic effects of anticancer drugs, thereby causing
Wamidh H. Talib +4 more
doaj +1 more source
Microenvironment drug resistance in multiple myeloma: emerging new players
OncoTarget, 2016 Multiple myeloma (MM) drug resistance (DR) is a multistep transformation process based on a powerful interplay between bone marrow stromal cells and MM cells that allows the latter to escape anti-myeloma therapies. Here we present an overview of the role
Lucia Di Marzo +8 more
semanticscholar +1 more source
Understanding cisplatin resistance using cellular models [PDF]
, 2007 Many mechanisms of cisplatin resistance have been proposed from studies of cellular models of resistance including changes in cellular drug accumulation, detoxification of the drug, inhibition of apoptosis and repair of the DNA adducts.
Davey, Mary W., Stordal, Britta
core +2 more sources
Xiehe Yixue Zazhi, 2023 Objective To study the resistance of Helicobacter pylori(Hp) isolated from Peking University People's Hospital to commonly used antibiotics, in order to provide basis for clinical rational drug use.
ZHANG Feifei +7 more
doaj +1 more source