Results 51 to 60 of about 1,436,718 (300)

Understanding the evolution of multiple drug resistance in structured populations

eLife, 2021
The evolution of multidrug resistance (MDR) is a pressing public health concern. Yet many aspects, such as the role played by population structure, remain poorly understood.
David V McLeod, Sylvain Gandon
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Understanding and targeting resistance mechanisms in cancer

MedComm, 2023
Resistance to cancer therapies has been a commonly observed phenomenon in clinical practice, which is one of the major causes of treatment failure and poor patient survival. The reduced responsiveness of cancer cells is a multifaceted phenomenon that can
Zi‐Ning Lei, Qin Tian, Qiu‐Xu Teng, John N. D. Wurpel, Leli Zeng, Yihang Pan, Zhe‐Sheng Chen   +6 more
doaj   +1 more source

In vitro development of chemotherapy and targeted therapy drug-resistant cancer cell lines: a practical guide with case studies [PDF]

, 2014
The development of a drug-resistant cell line can take from 3 to 18 months. However, little is published on the methodology of this development process. This article will discuss key decisions to be made prior to starting resistant cell line development;
Breen, Laura, Busschots, Steven, Clynes, Martin, Crown, John, Eustace, Alex J., McDermott, Martina, O'Donovan, Norma, Stordal, Britta K.   +7 more
core   +2 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Promising Anti-Mitochondrial Agents for Overcoming Acquired Drug Resistance in Multiple Myeloma

Cells, 2021
Multiple myeloma (MM) remains an incurable tumor due to the high rate of relapse that still occurs. Acquired drug resistance represents the most challenging obstacle to the extension of survival and several studies have been conducted to understand the ...
Vanessa Innao, Vincenzo Rizzo, Andrea Gaetano Allegra, Caterina Musolino, Alessandro Allegra   +4 more
doaj   +1 more source

Molar ratios of therapeutic water-soluble phenothiazine⋅water-insoluble phospholipid adducts reveal a Fibonacci correlation and a putative link for structure–activity relationships [PDF]

, 2015
The fact that non-antibiotics can sensitise microorganisms for antibiotic treatment suggests that these molecules have valuable potential to treat multiple drug resistance.
Fey, S. J., Keyzer, Hendrik, Kristiansen, Jette E., Thornton, Barry   +3 more
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Drug susceptibility of M. tuberculosis in tuberculosis patients from various population groups in Khanty-Mansiyskiy Autonomous Region

Туберкулез и болезни лёгких, 2015
The study included 287 cultures of tuberculous mycobacteria received from specimens of patients from Khanty-Mansiysky TB Dispensary in 2011-2012. Patients from Khanty-Mansiysky TB Dispensary have a fairly high rate (24.0%) of co-infection of TB and HIV ...
Yu. V. Reshetnikova, S. N. Аndreevskaya, E. E. Larionova   +2 more
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