Results 51 to 60 of about 2,071,500 (370)

Epigenetic strategies to reverse drug resistance in heterogeneous multiple myeloma

Clinical Epigenetics, 2017
Multiple myeloma (MM) is a hematological malignancy, which remains incurable because most patients eventually relapse or become refractory to current treatments. Due to heterogeneity within the cancer cell microenvironment, cancer cell populations employ
Mark E Issa, Farnaz Sedigheh Takhsha, C. S. Chirumamilla, C. Pérez-Novo, W. Vanden Berghe, M. Cuendet   +5 more
semanticscholar   +1 more source

Antiretroviral drug resistance mutations in naïve and experienced patients in Shiraz, Iran, 2014 [PDF]

, 2016
Resistance to antiretroviral agents is a significant concern in the clinical management of HIV-infected individuals, particularly in areas of the world where treatment options are limited.
Aghasadeghi, M.R., Baesi, K., Davarpanah, M.A., McFarland, W., Moradi, A., Naziri, H., Tabarraei, A.   +6 more
core   +1 more source

Insulin resistance in drug naive patients with multiple sclerosis [PDF]

Vojnosanitetski Pregled, 2017
Background/Aim. Due to the fact that there is a relatively small number of data related to systemic insulin abnormalities in the multiple sclerosis (MS), the main objective of our study was to determine whether a dysbalance of glucose and ...
Kostić Smiljana, Kolić Ivana, Raičević Ranko, Stojanović Zvezdana, Kostić Dejan, Dinčić Evica   +5 more
doaj   +1 more source

Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance. [PDF]

, 2016
The fungal pathogen Candida glabrata has emerged as a major health threat since it readily acquires resistance to multiple drug classes, including triazoles and/or echinocandins.
Alexander, B.D., Farmakiotis, D., Healey, K.R., Jimenez-Ortigosa, C., Kontoyiannis, D.P., Lockhart, S.R., Perez, W.B., Perlin, D.S., Sanglard, D., Shor, E., Sobel, J.D., Taj-Aldeen, S.J., Zhao, Y.   +12 more
core   +1 more source

Detection of multidrug-resistant Enterobacteriaceae isolated from river waters flowing to the Guanabara Bay and from clinical samples of hospitals in Rio de Janeiro, Brazil

Biomédica: revista del Instituto Nacional de Salud, 2019
Introduction: The use of antibiotics in humans, animal husbandry and veterinary activities induces selective pressure leading to the colonization and infection by resistant strains.
Verônica Dias Gonçalves, Frederico Meirelles-Pereira, Márcio Cataldo, Bianca de Oliveira Fonseca, Barbara Araujo Nogueira, Julianna Giordano Botelho Olivella, Francisco de Assis Esteves, Ana Luiza Mattos-Guaraldi, Arnaldo Feitosa Braga de Andrade, Alexandre Ribeiro Bello, José Augusto Adler Pereira   +10 more
doaj   +1 more source

Epigenetic Regulation of Antifungal Drug Resistance

Journal of Fungi, 2022
In medical mycology, epigenetic mechanisms are emerging as key regulators of multiple aspects of fungal biology ranging from development, phenotypic and morphological plasticity to antifungal drug resistance.
Sandip Patra, Mayur Raney, Aditi Pareek, Rupinder Kaur   +3 more
doaj   +1 more source

Advancing Drug Resistance Research Through Quantitative Modeling and Synthetic Biology [PDF]

Frontiers in Bioengineering and Biotechnology, 8: 583415 (2020), 2020
Antimicrobial resistance is an emerging global health crisis that is undermining advances in modern medicine and, if unmitigated, threatens to kill 10 million people per year worldwide by 2050. Research over the last decade has demonstrated that the differences between genetically identical cells in the same environment can lead to drug resistance ...
arxiv   +1 more source

Drug resistance in ovarian cancer: from mechanism to clinical trial

Molecular Cancer
Ovarian cancer is the leading cause of gynecological cancer-related death. Drug resistance is the bottleneck in ovarian cancer treatment. The increasing use of novel drugs in clinical practice poses challenges for the treatment of drug-resistant ovarian ...
Ling Wang, Xin Wang, Xueping Zhu, Lin Zhong, Qingxiu Jiang, Ya Wang, Qin Tang, Qiaoling Li, Cong Zhang, Haixia Wang, Dongling Zou   +10 more
semanticscholar   +1 more source

Multitarget Approaches against Multiresistant Superbugs [PDF]

, 2020
Despite efforts to develop new antibiotics, antibacterial resistance still develops too fast for drug discovery to keep pace. Often, resistance against a new drug develops even before it reaches the market.
Gray, Declan Alan, Wenzel, Michaela
core   +1 more source

m6A Modification in Non-Coding RNA: The Role in Cancer Drug Resistance

Frontiers in Oncology, 2021
Cancer drug resistance has always been a major difficulty in cancer therapy. In the face of drug pressure, resistant cancer cells show complex molecular mechanisms including epigenetic changes to maintain survival. Studies prove that cancer cells exhibit
Chen Chen, Chen Chen, Yuying Guo, Yaxin Guo, Yaxin Guo, Xiaoke Wu, Chaohua Si, Yanxin Xu, Qiaozhen Kang, Zhenqiang Sun   +9 more
doaj   +1 more source