Results 191 to 200 of about 114,219 (358)

Essential Role for the dsRNA-Dependent Protein Kinase PKR in Innate Immunity to Viral Infection [PDF]

, 2000
Siddharth Balachandran, Paul C. Roberts, Laura E Brown, Ha Truong, Asit K. Pattnaik, David R. Archer, Glen N. Barber   +6 more
openalex   +1 more source

Release of mitochondrial dsRNA into the cytosol is a key driver of the inflammatory phenotype of senescent cells

Nature Communications
The escape of mitochondrial double-stranded dsRNA (mt-dsRNA) into the cytosol has been recently linked to a number of inflammatory diseases. Here, we report that the release of mt-dsRNA into the cytosol is a general feature of senescent cells and a ...
Vanessa López-Polo, Mate Maus, Emmanouil Zacharioudakis, Miguel Lafarga, Camille Stephan-Otto Attolini, Francisco D. M. Marques, Marta Kovatcheva, Evripidis Gavathiotis, Manuel Serrano   +8 more
doaj   +1 more source

In situ quantification of ribosome number by electron tomography

Journal of Microscopy, EarlyView.
Abstract Ribosomes, discovered in 1955 by George Palade, were initially described as small cytoplasmic particles preferentially associated with the endoplasmic reticulum (ER). Over the years, extensive research has focused on both the structure and function of ribosomes.
Mounir El Hankouri, Marco Nousch, Aayush Poddar, Thomas Müller‐Reichert, Gunar Fabig   +4 more
wiley   +1 more source

Receptor‐like kinases BIR1 and BIR3 modulate antiviral resistance by different mechanisms

New Phytologist, EarlyView.
Summary BRASSINOSTEROID INSENSITIVE1‐ASSOCIATED RECEPTOR KINASE 1 (BAK1)‐INTERACTING RECEPTOR‐LIKE KINASE (BIR) proteins are negative regulators of cell death and defense against microbes in Arabidopsis thaliana. Here, we demonstrate that the members of the BIR family function as negative regulators of antiviral resistance in Arabidopsis.
Carmen Robinson, Irene Guzmán‐Benito, Ana Rocío Sede, Laura Elvira‐González, Chenlei Hua, Malgorzata Ciska, Thorsten Nürnberger, Manfred Heinlein, César Llave   +8 more
wiley   +1 more source

Induction of apoptosis by the dsRNA-dependent protein kinase (PKR): mechanism of action. [PDF]

, 2000
Jesús Gil, Mariano Estéban
openalex   +1 more source

Microarray evidence for off target effects in tick RNA interference experiments, and the lack of strong correlation between DSRNA and antibody phenotypes in tick In vitro treatments for vaccine candidate screening [PDF]

, 2011
No abstract ...
Barrero, R., Bellgard, M.I., Bruyeres, A.B., Gondro, C., Kurscheid, S., Lew-Tabor, A., Moolhuijzen, P.M., Morgan, J.A.T., Rodriguez-Valle, M., Zhang, B.   +9 more
core   +1 more source

Plant‐derived vesicle‐like nanoparticles in food crops: emerging insights into nutritional biofortification and biomedical applications

Plant Biotechnology Journal, EarlyView.
Summary Food crops, as the cornerstone of human nutrition, not only provide essential macronutrients but also encompass a rich spectrum of bioactive compounds that promote health. Of particular significance are underutilized minor crops, which contain unique beneficial components with proven nutraceutical properties. These valuable bioactive components
Jie Wang, Zhaosheng Kong
wiley   +1 more source

Evidence that processed small dsRNAs may mediate sequence-specific mRNA degradation during RNAi in Drosophila embryos [PDF]

, 2000
Dun Yang, Hong Lü, James Erickson
openalex   +1 more source

Host‐induced gene silencing of the amino acid biosynthesis gene acetolactate synthase of Phytophthora infestans caused strong enhanced late blight resistance of potato in the field

Plant Biotechnology Journal, EarlyView.
Summary Late blight caused by Phytophthora infestans is the most serious disease of potatoes. Here we present the effectiveness of the host‐induced gene silencing (HIGS) technology against an amino acid biosynthesis gene of the pathogen to increase the resistance against the plant‐infecting oomycete in the field.
Nora Temme, Tobias Haehre, Clarissa Boyher, Lydia Hoppe, Colin Davenport, Zach Stumo, Kai Prenzler, Anja Maeser, Maike Pflugmacher, Kerstin Koch, Dietmar J. Stahl   +10 more
wiley   +1 more source

The Zα domain of the editing enzyme dsRNA adenosine deaminase binds left-handed Z-RNA as well as Z-DNA [PDF]

, 2000
Bernard A. Brown, Ky Lowenhaupt, Christina M. Wilbert, Eugene B. Hanlon, Alexander Rich   +4 more
openalex   +1 more source