Results 101 to 110 of about 43,287 (283)

RNA-directed activation of cytoplasmic dynein-1 in reconstituted transport RNPs

bioRxiv, 2018
Polarised mRNA transport is a prevalent mechanism for spatial control of protein synthesis. However, the composition of transported ribonucleoprotein particles (RNPs) and the regulation of their movement are poorly understood.
M. McClintock, Carly I Dix, Christopher M. Johnson, S. McLaughlin, R. Maizels, Ha Thanh Thi Hoang, S. Bullock   +6 more
semanticscholar   +1 more source

Activation and Regulation of Cytoplasmic Dynein

Trends in Biochemical Sciences, 2020
Cytoplasmic dynein is an AAA+ motor that drives the transport of many intracellular cargoes towards the minus end of microtubules (MTs). Previous in vitro studies characterized isolated dynein as an exceptionally weak motor that moves slowly and diffuses on an MT. Recent studies altered this view by demonstrating that dynein remains in an autoinhibited
John T. Canty, Ahmet Yildiz
openaire   +5 more sources

Genetic differences between primary colorectal cancer and its paired synchronous and metachronous metastases

International Journal of Cancer, EarlyView.
What's New? Colorectal cancer (CRC) frequently metastasizes to the liver, either synchronously with primary diagnosis or metachronously, after variable time intervals. Although implicated, the role of genetic factors in driving synchronous and metachronous disease progression remains uncertain.
Marie Rajtmajerova, Filip Ambrozkiewicz, Viktor Hlavac, Andriy Trailin, Lenka Cervenkova, Jan Bruha, Simona Susova, Pavel Soucek, Pavel Vodicka, Ludmila Vodickova, Ondrej Kubecek, Stanislav Filip, Venkata R. Mallela, Wenjing Ye, Frantisek Zitricky, Vaclav Liska, Kari Hemminki   +16 more
wiley   +1 more source

The XMAP215-family protein DdCP224 is required for cortical interactions of microtubules

BMC Cell Biology, 2004
Background Interactions of peripheral microtubule tips with the cell cortex are of crucial importance for nuclear migration, spindle orientation, centrosome positioning and directional cell movement.
Hestermann Andrea, Gräf Ralph
doaj   +1 more source

Structure of dynein–dynactin on microtubules shows tandem adaptor binding

Nature, 2022
Sami Chaaban, A. Carter
semanticscholar   +1 more source

Dynein activator Hook1 is required for trafficking of BDNF-signaling endosomes in neurons

Journal of Cell Biology, 2018
&NA; Axonal transport is required for neuronal development and survival. Transport from the axon to the soma is driven by the molecular motor cytoplasmic dynein, yet it remains unclear how dynein is spatially and temporally regulated.
Mara A Olenick, R. Dominguez, E. Holzbaur   +2 more
semanticscholar   +1 more source

Multiomics Reveal Associations Between CpG Methylation, Histone Modifications and Transcription in a Species That has Lost DNMT3, the Colorado Potato Beetle

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Despite lacking DNMT3, EM‐seq revealed CpG methylation in the Colorado potato beetle. CUT&Tag analysis showed an association of H3K36me3 and H3K27ac with transcription, with H3K36me3 mirroring CpG methylation, demonstrating epigenetic flexibility.
Zoe M. Länger, Elisa Israel, Jan Engelhardt, Agata I. Kalita, Claudia I. Keller Valsecchi, Joachim Kurtz, Sonja J. Prohaska   +6 more
wiley   +1 more source

X-linked primary ciliary dyskinesia due to mutations in the cytoplasmic axonemal dynein assembly factor PIH1D3

Nature Communications, 2017
By moving essential body fluids and molecules, motile cilia and flagella govern respiratory mucociliary clearance, laterality determination and the transport of gametes and cerebrospinal fluid.
C. Olcese, M. Patel, A. Shoemark, S. Kiviluoto, M. Legendre, H. Williams, C. Vaughan, Jane D. Hayward, A. Goldenberg, Richard D Emes, M. Munye, Laura Dyer, Thomas Cahill, J. Bevillard, C. Gehrig, M. Guipponi, S. Chantot, P. Duquesnoy, Lucie Thomas, L. Jeanson, B. Copin, A. Tamalet, C. Thauvin-Robinet, J. Papon, A. Garin, I. Pin, Gabriella Vera, P. Aurora, Mahmoud R. Fassad, L. Jenkins, Christopher Boustred, T. Cullup, M. Dixon, A. Onoufriadis, A. Bush, E. Chung, S. Antonarakis, M. Loebinger, R. Wilson, M. Armengot, E. Escudier, C. Hogg, S. Amselem, Zhaoxia Sun, L. Bartoloni, J. Blouin, H. Mitchison, S. Al-Turki, C. Anderson, D. Antony, I. Barroso, P. Beales, J. Bentham, S. Bhattacharya, K. Carss, K. Chatterjee, S. Çırak, C. Cosgrove, Daly Allan, R. Durbin, David Fitzpatrick, J. Floyd, A. Foley, C. Franklin, M. Futema, S. Humphries, M. Hurles, Shane A. McCarthy, Dawn Muddyman, F. Muntoni, V. Parker, F. Payne, V. Plagnol, L. Raymond, D. Savage, P. Scambler, M. Schmidts, R. Semple, E. Serra, J. Stalker, M. van Kogelenberg, Parthiban Vijayarangakannan, Klaudia Walter   +82 more
semanticscholar   +1 more source

DOCK8 deficiency presenting with sclerosing cholangitis, raised immunoglobulin E, and bronchiectasis: A fatal pediatric case report

JPGN Reports, EarlyView.
Abstract Dedicator of cytokinesis 8 (DOCK8) deficiency is a rare autosomal recessive primary immunodeficiency. Patients with DOCK8 deficiency typically present at early age with allergic manifestations, cutaneous and respiratory infections, raised immunoglobulin E, and they have an increased risk of developing malignancies.
Natalia Nedelkopoulou, Kelechi Ugonna, Stephen Hughes, Sanjay Rajwal, Marumbo Mtegha   +4 more
wiley   +1 more source

She1 affects dynein through direct interactions with the microtubule and the dynein microtubule-binding domain

Nature Communications, 2017
Dynein is a microtubule motor the motility of which is affected by the microtubule-associated protein She1. Here, the authors show that She1 alters dynein stepping behavior and increases its microtubule affinity through simultaneous interactions with the
Kari H. Ecklund, Tatsuya Morisaki, Lindsay G. Lammers, Matthew G. Marzo, Timothy J. Stasevich, Steven M. Markus   +5 more
doaj   +1 more source